In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
Gameiro, Paulo A., Yang, Juanjuan, Metelo, Ana M., Pérez-Carro, Rocio, Baker, Rania, Wang, Zongwei, Arreola, Alexandra, Rathmell, W. Kimryn, Olumi, Aria, López-Larrubia, Pilar, Stephanopoulos, Gregory, Iliopoulos, Othon
Published in Cell metabolism (05.03.2013)
Published in Cell metabolism (05.03.2013)
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Journal Article
Evaluation, diagnosis and surveillance of renal masses in the setting of VHL disease
Chahoud, Jad, McGettigan, Melissa, Parikh, Nainesh, Boris, Ronald S., Iliopoulos, Othon, Rathmell, W. Kimryn, Daniels, Anthony B., Jonasch, Eric, Spiess, Philippe E.
Published in World journal of urology (01.07.2021)
Published in World journal of urology (01.07.2021)
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Journal Article
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
Laviolette, Laura A., Mermoud, Julien, Calvo, Isabel A., Olson, Nicholas, Boukhali, Myriam, Steinlein, Ortrud K., Roider, Elisabeth, Sattler, Elke C., Huang, Dachuan, Teh, Bin Tean, Motamedi, Mo, Haas, Wilhelm, Iliopoulos, Othon
Published in Nature communications (28.06.2017)
Published in Nature communications (28.06.2017)
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Journal Article
MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species
Roider, Elisabeth, Lakatos, Alexandra I. T., McConnell, Alicia M., Wang, Poguang, Mueller, Alina, Kawakami, Akinori, Tsoi, Jennifer, Szabolcs, Botond L., Ascsillán, Anna A., Suita, Yusuke, Igras, Vivien, Lo, Jennifer A., Hsiao, Jennifer J., Lapides, Rebecca, Pál, Dorottya M. P., Lengyel, Anna S., Navarini, Alexander, Okazaki, Arimichi, Iliopoulos, Othon, Németh, István, Graeber, Thomas G., Zon, Leonard, Giese, Roger W., Kemeny, Lajos V., Fisher, David E.
Published in Scientific reports (14.09.2024)
Published in Scientific reports (14.09.2024)
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Journal Article
Case 36-2018: A 29-Year-Old Man with an Incidentally Discovered Renal Mass
Dahl, Douglas M, Simeone, Joseph F, Iliopoulos, Othon, Saylor, Philip J, Wu, Chin-Lee
Published in The New England journal of medicine (22.11.2018)
Published in The New England journal of medicine (22.11.2018)
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Journal Article
Conference Proceeding
Loss of RBF1 changes glutamine catabolism
Nicolay, Brandon N, Gameiro, Paulo A, Tschöp, Katrin, Korenjak, Michael, Heilmann, Andreas M, Asara, John M, Stephanopoulos, Gregory, Iliopoulos, Othon, Dyson, Nicholas J
Published in Genes & development (15.01.2013)
Published in Genes & development (15.01.2013)
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Journal Article
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors
Zimmer, Michael, Doucette, Darrell, Siddiqui, Naila, Iliopoulos, Othon
Published in Molecular cancer research (01.02.2004)
Published in Molecular cancer research (01.02.2004)
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Journal Article
Comparative Studies of the Proteome, Glycoproteome, and N‑Glycome of Clear Cell Renal Cell Carcinoma Plasma before and after Curative Nephrectomy
Gbormittah, Francisca O, Lee, Ling Y, Taylor, KyOnese, Hancock, William S, Iliopoulos, Othon
Published in Journal of proteome research (07.11.2014)
Published in Journal of proteome research (07.11.2014)
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Journal Article
Clusterin Glycopeptide Variant Characterization Reveals Significant Site-Specific Glycan Changes in the Plasma of Clear Cell Renal Cell Carcinoma
Gbormittah, Francisca O., Bones, Jonathan, Hincapie, Marina, Tousi, Fateme, Hancock, William S., Iliopoulos, Othon
Published in Journal of proteome research (05.06.2015)
Published in Journal of proteome research (05.06.2015)
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Journal Article
Seventh BHD international symposium: recent scientific and clinical advancement
Woodford, Mark R, Andreou, Avgi, Baba, Masaya, van de Beek, Irma, Di Malta, Chiara, Glykofridis, Iris, Grimes, Hannah, Henske, Elizabeth P, Iliopoulos, Othon, Kurihara, Masatoshi, Lazor, Romain, Linehan, W Marston, Matsumoto, Kenki, Marciniak, Stefan J, Namba, Yukiko, Pause, Arnim, Rajan, Neil, Ray, Anindita, Schmidt, Laura S, Shi, Wei, Steinlein, Ortrud K, Thierauf, Julia, Zoncu, Roberto, Webb, Anna, Mollapour, Mehdi
Published in Oncotarget (20.01.2022)
Published in Oncotarget (20.01.2022)
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Journal Article
Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL
Arevalo, Aileen, Patel, Neal, Muraki, Peter, Ohtake, Shinji, Bratslavsky, Gennady, Clark, Chandra, Mann, Joshua, Iliopoulos, Othon, Jonasch, Eric, Srinivasan, Ramaprasad, Shuch, Brian
Published in Journal of kidney cancer and VHL (01.01.2022)
Published in Journal of kidney cancer and VHL (01.01.2022)
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Journal Article
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
MIZUKAMI, Yusuke, JINGNAN LI, XIAOBO ZHANG, ZIMMER, Michael A, ILIOPOULOS, Othon, CHUNG, Daniel C
Published in Cancer research (Chicago, Ill.) (01.03.2004)
Published in Cancer research (Chicago, Ill.) (01.03.2004)
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Journal Article
Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations
Laviolette, Laura A, Wilson, Jonas, Koller, Julia, Neil, Christopher, Hulick, Peter, Rejtar, Tomas, Karger, Barry, Teh, Bin Tean, Iliopoulos, Othon
Published in PloS one (11.07.2013)
Published in PloS one (11.07.2013)
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Journal Article
Belzutifan for Renal Cell Carcinoma in von Hippel–Lindau Disease
Jonasch, Eric, Donskov, Frede, Iliopoulos, Othon, Rathmell, W. Kimryn, Narayan, Vivek K., Maughan, Benjamin L., Oudard, Stephane, Else, Tobias, Maranchie, Jodi K., Welsh, Sarah J., Thamake, Sanjay , Park, Eric K., Perini, Rodolfo F., Linehan, W. Marston, Srinivasan, Ramaprasad
Published in The New England journal of medicine (25.11.2021)
Published in The New England journal of medicine (25.11.2021)
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Journal Article
The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability
Calvo, Isabel A., Sharma, Shalini, Paulo, Joao A., Gulka, Alexander O.D., Boeszoermenyi, Andras, Zhang, Jingyu, Lombana, Jose M., Palmieri, Christina M., Laviolette, Laura A., Arthanari, Haribabu, Iliopoulos, Othon, Gygi, Steven P., Motamedi, Mo
Published in iScience (19.11.2021)
Published in iScience (19.11.2021)
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Journal Article
Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2
Lonergan, Kim M., Iliopoulos, Othon, Ohh, Michael, Kamura, Takumi, Conaway, Ronald C., Conaway, Joan Weliky, Kaelin, William G.
Published in Molecular and Cellular Biology (01.02.1998)
Published in Molecular and Cellular Biology (01.02.1998)
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