TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
Chen, Chong, Liu, Yu, Liu, Runhua, Ikenoue, Tsuneo, Guan, Kun-Liang, Liu, Yang, Zheng, Pan
Published in The Journal of experimental medicine (29.09.2008)
Published in The Journal of experimental medicine (29.09.2008)
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Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation
Miguchi, Masashi, Hinoi, Takao, Shimomura, Manabu, Adachi, Tomohiro, Saito, Yasufumi, Niitsu, Hiroaki, Kochi, Masatoshi, Sada, Haruki, Sotomaru, Yusuke, Ikenoue, Tsuneo, Shigeyasu, Kunitoshi, Tanakaya, Kohji, Kitadai, Yasuhiko, Sentani, Kazuhiro, Oue, Naohide, Yasui, Wataru, Ohdan, Hideki
Published in PloS one (11.11.2016)
Published in PloS one (11.11.2016)
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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
Yang, Qian, Inoki, Ken, Ikenoue, Tsuneo, Guan, Kun-Liang
Published in Genes & development (15.10.2006)
Published in Genes & development (15.10.2006)
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Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis
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Published in The Journal of clinical investigation (01.06.2022)
Published in The Journal of clinical investigation (01.06.2022)
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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Zhao, Bin, Wei, Xiaomu, Li, Weiquan, Udan, Ryan S, Yang, Qian, Kim, Joungmok, Xie, Joe, Ikenoue, Tsuneo, Yu, Jindan, Li, Li, Zheng, Pan, Ye, Keqiang, Chinnaiyan, Arul, Halder, Georg, Lai, Zhi-Chun, Guan, Kun-Liang
Published in Genes & development (01.11.2007)
Published in Genes & development (01.11.2007)
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NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice
Maeda, Shin, Hikiba, Yohko, Fujiwara, Hiroaki, Ikenoue, Tsuneo, Sue, Soichiro, Sugimori, Makoto, Matsubayashi, Mao, Kaneko, Hiroaki, Irie, Kuniyasu, Sasaki, Tomohiko, Chuma, Makoto
Published in Cancer science (01.04.2021)
Published in Cancer science (01.04.2021)
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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
Inoki, Ken, Mori, Hiroyuki, Wang, Junying, Suzuki, Tsukasa, Hong, SungKi, Yoshida, Sei, Blattner, Simone M, Ikenoue, Tsuneo, Rüegg, Markus A, Hall, Michael N, Kwiatkowski, David J, Rastaldi, Maria P, Huber, Tobias B, Kretzler, Matthias, Holzman, Lawrence B, Wiggins, Roger C, Guan, Kun-Liang
Published in The Journal of clinical investigation (01.06.2011)
Published in The Journal of clinical investigation (01.06.2011)
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Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis
Liu, Xun, Yamaguchi, Kiyoshi, Takane, Kiyoko, Zhu, Chi, Hirata, Makoto, Hikiba, Yoko, Maeda, Shin, Furukawa, Yoichi, Ikenoue, Tsuneo
Published in PloS one (13.09.2021)
Published in PloS one (13.09.2021)
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Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis
Nakatsuka, Takuma, Tateishi, Keisuke, Kato, Hiroyuki, Fujiwara, Hiroaki, Yamamoto, Keisuke, Kudo, Yotaro, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Ikenoue, Tsuneo, Ishizawa, Takeaki, Hasegawa, Kiyoshi, Tachibana, Makoto, Shinkai, Yoichi, Koike, Kazuhiko
Published in Cell death & disease (19.01.2021)
Published in Cell death & disease (19.01.2021)
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Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
Ijichi, Hideaki, Chytil, Anna, Gorska, Agnieszka E, Aakre, Mary E, Bierie, Brian, Tada, Motohisa, Mohri, Dai, Miyabayashi, Koji, Asaoka, Yoshinari, Maeda, Shin, Ikenoue, Tsuneo, Tateishi, Keisuke, Wright, Christopher V E, Koike, Kazuhiko, Omata, Masao, Moses, Harold L
Published in The Journal of clinical investigation (01.10.2011)
Published in The Journal of clinical investigation (01.10.2011)
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Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis
Nakagawa, Hayato, Hikiba, Yohko, Hirata, Yoshihiro, Font-Burgada, Joan, Sakamoto, Kei, Hayakawa, Yoku, Taniguchi, Koji, Umemura, Atsushi, Kinoshita, Hiroto, Sakitani, Kosuke, Nishikawa, Yuji, Hirano, Kenji, Ikenoue, Tsuneo, Ijichi, Hideaki, Dhar, Debanjan, Shibata, Wataru, Akanuma, Masao, Koike, Kazuhiko, Karin, Michael, Maeda, Shin
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.2014)
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Application of targeted nanopore sequencing for the screening and determination of structural variants in patients with Lynch syndrome
Yamaguchi, Kiyoshi, Kasajima, Rika, Takane, Kiyoko, Hatakeyama, Seira, Shimizu, Eigo, Yamaguchi, Rui, Katayama, Kotoe, Arai, Masami, Ishioka, Chikashi, Iwama, Takeo, Kaneko, Satoshi, Matsubara, Nagahide, Moriya, Yoshihiro, Nomizu, Tadashi, Sugano, Kokichi, Tamura, Kazuo, Tomita, Naohiro, Yoshida, Teruhiko, Sugihara, Kenichi, Nakamura, Yusuke, Miyano, Satoru, Imoto, Seiya, Furukawa, Yoichi, Ikenoue, Tsuneo
Published in Journal of human genetics (01.11.2021)
Published in Journal of human genetics (01.11.2021)
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Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium
Kinoshita, Hiroto, Hayakawa, Yoku, Konishi, Mitsuru, Hata, Masahiro, Tsuboi, Mayo, Hayata, Yuki, Hikiba, Yohko, Ihara, Sozaburo, Nakagawa, Hayato, Ikenoue, Tsuneo, Ushiku, Tetsuo, Fukayama, Masashi, Hirata, Yoshihiro, Koike, Kazuhiko
Published in The Journal of pathology (01.01.2019)
Published in The Journal of pathology (01.01.2019)
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Identification of odontogenic ameloblast associated as a novel target gene of the Wnt/β‐catenin signaling pathway
Yamaguchi, Kiyoshi, Horie, Chiaki, Takane, Kiyoko, Ikenoue, Tsuneo, Nakagawa, Saya, Isobe, Yumiko, Ota, Yasunori, Ushiku, Tetsuo, Tanaka, Mariko, Fujishiro, Jun, Hoshino, Noriko, Arisue, Atsuhiro, Nishizuka, Satoshi, Aikou, Susumu, Shida, Dai, Furukawa, Yoichi
Published in Cancer science (01.03.2023)
Published in Cancer science (01.03.2023)
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Importance of gastric cancer for the diagnosis and surveillance of Japanese Lynch syndrome patients
Ikenoue, Tsuneo, Arai, Masami, Ishioka, Chikashi, Iwama, Takeo, Kaneko, Satoshi, Matsubara, Nagahide, Moriya, Yoshihiro, Nomizu, Tadashi, Sugano, Kokichi, Tamura, Kazuo, Tomita, Naohiro, Yoshida, Teruhiko, Sugihara, Kenichi, Naruse, Hiromu, Yamaguchi, Kiyoshi, Nojima, Masanori, Nakamura, Yusuke, Furukawa, Yoichi
Published in Journal of human genetics (01.12.2019)
Published in Journal of human genetics (01.12.2019)
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A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion
Ikenoue, Tsuneo, Terakado, Yumi, Nakagawa, Hayato, Hikiba, Yohko, Fujii, Tomoaki, Matsubara, Daisuke, Noguchi, Rei, Zhu, Chi, Yamamoto, Keisuke, Kudo, Yotaro, Asaoka, Yoshinari, Yamaguchi, Kiyoshi, Ijichi, Hideaki, Tateishi, Keisuke, Fukushima, Noriyoshi, Maeda, Shin, Koike, Kazuhiko, Furukawa, Yoichi
Published in Scientific reports (01.04.2016)
Published in Scientific reports (01.04.2016)
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Bidirectional reporter assay using HAL promoter and TOPFLASH improves specificity in high‐throughput screening of Wnt inhibitors
Yamaguchi, Kiyoshi, Zhu, Chi, Ohsugi, Tomoyuki, Yamaguchi, Yuko, Ikenoue, Tsuneo, Furukawa, Yoichi
Published in Biotechnology and bioengineering (01.12.2017)
Published in Biotechnology and bioengineering (01.12.2017)
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Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression
Mohri, Dai, Asaoka, Yoshinari, Ijichi, Hideaki, Miyabayashi, Koji, Kudo, Yotaro, Seto, Motoko, Ohta, Miki, Tada, Motohisa, Tanaka, Yasuo, Ikenoue, Tsuneo, Tateishi, Keisuke, Isayama, Hiroyuki, Kanai, Fumihiko, Fukushima, Noriyoshi, Tada, Minoru, Kawabe, Takao, Omata, Masao, Koike, Kazuhiko
Published in Journal of gastroenterology (01.02.2012)
Published in Journal of gastroenterology (01.02.2012)
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Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene
Takahashi, Norihiko, Yamaguchi, Kiyoshi, Ikenoue, Tsuneo, Fujii, Tomoaki, Furukawa, Yoichi
Published in PloS one (22.01.2014)
Published in PloS one (22.01.2014)
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