Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients
Nagata, Eiichiro, Ogino, Mieko, Iwamoto, Kounosuke, Kitagawa, Yasuhisa, Iwasaki, Yasuo, Yoshii, Fumihito, Ikeda, Joh-E
Published in PloS one (24.02.2016)
Published in PloS one (24.02.2016)
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Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms
Kano, Osamu, Tanaka, Kazunori, Kanno, Takuya, Iwasaki, Yasuo, Ikeda, Joh-E
Published in Scientific reports (08.01.2018)
Published in Scientific reports (08.01.2018)
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Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking
Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Akatsuka, Akira, Koike, Masato, Aoki, Masashi, Uchiyama, Yasuo, Itoyama, Yasuto, Ikeda, Joh-E
Published in PloS one (22.03.2010)
Published in PloS one (22.03.2010)
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Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis
Tanaka, Kazunori, Kanno, Takuya, Yanagisawa, Yoshiko, Yasutake, Kaori, Hadano, Shinji, Yoshii, Fumihito, Ikeda, Joh-E
Published in Experimental neurology (01.11.2011)
Published in Experimental neurology (01.11.2011)
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Correction: Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients
Nagata, Eiichiro, Ogino, Mieko, Iwamoto, Kounosuke, Kitagawa, Yasuhisa, Iwasaki, Yasuo, Yoshii, Fumihito, Ikeda, Joh-E
Published in PloS one (28.03.2016)
Published in PloS one (28.03.2016)
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ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth
Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Mizumura, Hikaru, Onoe, Kyuichiro, Osuga, Hitoshi, Hadano, Shinji, Ikeda, Joh-E.
Published in Biochemical and biophysical research communications (23.05.2008)
Published in Biochemical and biophysical research communications (23.05.2008)
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Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking
Hadano, Shinji, Benn, Susanna C., Kakuta, Shigeru, Otomo, Asako, Sudo, Katsuko, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Mizumura, Hikaru, Shefner, Jeremy M., Cox, Gregory A., Iwakura, Yoichiro, Brown, Robert H., Ikeda, Joh-E
Published in Human molecular genetics (15.01.2006)
Published in Human molecular genetics (15.01.2006)
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Cyclin-Dependent Kinases as a Therapeutic Target for Stroke
Osuga, H, Osuga, S, Wang, F, Fetni, R, Hogan, M J, Slack, R S, Hakim, A M, Ikeda, J E, Park, D S
Published in Proceedings of the National Academy of Sciences - PNAS (29.08.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (29.08.2000)
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Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice
Hadano, Shinji, Yoshii, Yasuhiro, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Pan, Lei, Kakuta, Shigeru, Iwasaki, Yasuo, Iwakura, Yoichiro, Ikeda, Joh-E
Published in Neuroscience research (01.10.2010)
Published in Neuroscience research (01.10.2010)
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Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking
Kunita, Ryota, Otomo, Asako, Mizumura, Hikaru, Suzuki, Kyoko, Showguchi-Miyata, Junko, Yanagisawa, Yoshiko, Hadano, Shinji, Ikeda, Joh-E
Published in The Journal of biological chemistry (10.09.2004)
Published in The Journal of biological chemistry (10.09.2004)
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Novel Nuclear Shuttle Proteins, HDBP1 and HDBP2, Bind to Neuronal Cell-specific cis-Regulatory Element in the Promoter for the Human Huntington's Disease Gene
Tanaka, Kazunori, Shouguchi-Miyata, Junko, Miyamoto, Natsuki, Ikeda, Joh-E
Published in The Journal of biological chemistry (20.02.2004)
Published in The Journal of biological chemistry (20.02.2004)
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Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance After Global Ischemia in the Rat
Wang, Fuhu, Corbett, Dale, Osuga, Hitoshi, Osuga, Sachiko, Ikeda, Joh-E, Slack, Ruth S., Hogan, Matthew J., Hakim, Antoine M., Park, David S.
Published in Journal of cerebral blood flow and metabolism (01.02.2002)
Published in Journal of cerebral blood flow and metabolism (01.02.2002)
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A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2–ARE pathway: Therapeutic implications for ALS
Kanno, Takuya, Tanaka, Kazunori, Yanagisawa, Yoshiko, Yasutake, Kaori, Hadano, Shinji, Yoshii, Fumihito, Hirayama, Noriaki, Ikeda, Joh-E
Published in Free radical biology & medicine (01.12.2012)
Published in Free radical biology & medicine (01.12.2012)
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ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics
Suzuki-Utsunomiya, Kyoko, Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Mizumura, Hikaru, Osuga, Hitoshi, Ikeda, Joh-E
Published in Biochemical and biophysical research communications (09.03.2007)
Published in Biochemical and biophysical research communications (09.03.2007)
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Morphodynamics of ovarian follicles during oogenesis in mice
Sato, Eimei, Kimura, Naoko, Yokoo, Masaki, Miyake, Yuko, Ikeda, Joh-E
Published in Microscopy research and technique (01.06.2006)
Published in Microscopy research and technique (01.06.2006)
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Journal Article
ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics
Hadano, Shinji, Otomo, Asako, Suzuki-Utsunomiya, Kyoko, Kunita, Ryota, Yanagisawa, Yoshiko, Showguchi-Miyata, Junko, Mizumura, Hikaru, Ikeda, Joh-E
Published in FEBS letters (24.09.2004)
Published in FEBS letters (24.09.2004)
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Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation
Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Ikeda, Joh-E, Hadano, Shinji
Published in FEBS letters (09.03.2011)
Published in FEBS letters (09.03.2011)
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The structures of integration sites in transgenic rice
Takano, Makoto, Egawa, Hitomi, Ikeda, Joh‐E, Wakasa, Kyo
Published in The Plant journal : for cell and molecular biology (01.03.1997)
Published in The Plant journal : for cell and molecular biology (01.03.1997)
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