Phase I study of DFP-11207, a novel oral fluoropyrimidine with reasonable AUC and low Cmax and improved tolerability, in patients with solid tumors
Ajani, Jaffer A., Javle, Milind, Eng, Cathy, Fogelman, David, Smith, Jackie, Anderson, Barry, Zhang, Chun, Iizuka, Kenzo
Published in Investigational new drugs (01.12.2020)
Published in Investigational new drugs (01.12.2020)
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Pressure transmitting medium Daphne 7474 solidifying at 3.7 GPa at room temperature
Murata, Keizo, Yokogawa, Keiichi, Yoshino, Harukazu, Klotz, Stefan, Munsch, Pascal, Irizawa, Akinori, Nishiyama, Mototsugu, Iizuka, Kenzo, Nanba, Takao, Okada, Tahei, Shiraga, Yoshitaka, Aoyama, Shoji
Published in Review of scientific instruments (01.08.2008)
Published in Review of scientific instruments (01.08.2008)
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Relative kinetic reactivity of boronic acid and boronate ion towards Tiron, 2,2'-biphenol, and propylene glycol
Watanabe, Eisuke, Miyamoto, Chiaki, Tanaka, Asumi, Iizuka, Kenzo, Iwatsuki, Satoshi, Inamo, Masahiko, Takagi, Hideo D, Ishihara, Koji
Published in Dalton transactions : an international journal of inorganic chemistry (21.06.2013)
Published in Dalton transactions : an international journal of inorganic chemistry (21.06.2013)
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Journal Article
Phase I study of DFP-11207, a novel oral fluoropyrimidine with reasonable AUC and low C max and improved tolerability, in patients with solid tumors
Ajani, Jaffer A, Javle, Milind, Eng, Cathy, Fogelman, David, Smith, Jackie, Anderson, Barry, Zhang, Chun, Iizuka, Kenzo
Published in Investigational new drugs (01.12.2020)
Published in Investigational new drugs (01.12.2020)
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Journal Article
Phase I study of DFP-11207, a novel oral 5-FU with enhanced PK and improved tolerability, in patients with solid tumors
Ajani, Jaffer A., Javle, Milind M., Eng, Cathy, Fogelman, David R., Anderson, Barry Douglas, Zhang, Chun, Iizuka, Kenzo
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Analysis of the prolonged infusion of DFP-10917, a deoxycytidine analog, as a therapeutic strategy for the treatment of human tumor xenografts in vivo
Iizuka, Kenzo, Zhang, Chun, Eshima, Kokoro, Jin, Cheng, Eshima, Kiyoshi, Fukushima, Masakazu
Published in International journal of oncology (01.03.2018)
Published in International journal of oncology (01.03.2018)
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Abstract 5099: Development of novel antimetabolite, DFP-11207, with self-toxicity protection and its promising preclinical and clinical profiles
Fukushima, Masakazu, Iizuka, Kenzo, Eshima, Kokoro, Zhang, Chung, Jin, Cheng, Eshima, Kiyoshi, Ajani, Jaffer
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Phase I study of DFP-11207, a novel chemotherapeutic agent, in patients with solid tumors by reasonable dose escalation
Ajani, Jaffer A., Eng, Cathy, Javle, Milind, Hernandez, Katrina, Anderson, Barry D., Zhang, Chun, Iizuka, Kenzo
Published in Annals of oncology (01.11.2016)
Published in Annals of oncology (01.11.2016)
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Abstract 2192: DFP-10825 IP delivery provides a new effective treatment option to peritoneal-disseminated cancers
Jin, Cheng, Iizuka, Kenzo, Eshima, Kokoro, Fukushima, Masakazu, Ishida, Tatsuhiro, Huang, Cheng-Long, Wada, Hiromi, Eshima, Kiyoshi
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Phase 1/2 study of DFP‐10917 administered by continuous intravenous infusion in patients with recurrent or refractory acute myeloid leukemia
Kantarjian, Hagop M., Jabbour, Elias J., Garcia‐Manero, Guillermo, Kadia, Tapan M., DiNardo, Courtney D., Daver, Naval G., Borthakur, Gautam, Jain, Nitin, Waukau, Jane B., Kwari, Monica I., Ravandi, Farhad, Anderson, Barry D., Iizuka, Kenzo, Jin, Cheng, Zhang, Chun, Plunkett, William K.
Published in Cancer (15.05.2019)
Published in Cancer (15.05.2019)
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Phase II study of DFP-10917, a deoxycytidine analog, given by 14-day continuous intravenous infusion for chemotherapy-refractory advanced colorectal cancer
Mehrvarz Sarshekeh, Amir, Xiong, Henry Q., Iizuka, Kenzo, Hochster, Howard S., Kopetz, Scott
Published in Investigational new drugs (01.10.2018)
Published in Investigational new drugs (01.10.2018)
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Anticancer activity of the intraperitoneal-delivered DFP-10825, the cationic liposome-conjugated RNAi molecule targeting thymidylate synthase, on peritoneal disseminated ovarian cancer xenograft model
Iizuka, Kenzo, Jin, Cheng, Eshima, Kokoro, Hong, Mei Hua, Eshima, Kiyoshi, Fukushima, Masakazu
Published in Drug design, development and therapy (01.01.2018)
Published in Drug design, development and therapy (01.01.2018)
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Journal Article
Two phase I, pharmacokinetic, and pharmacodynamic studies of DFP-10917, a novel nucleoside analog with 14-day and 7-day continuous infusion schedules
Sankhala, Kamalesh, Takimoto, Chris H., Mita, Alain C., Xiong, Henry, Rodón, Jordi, Mehrvarz Sarshekeh, Amir, Burns, K., Iizuka, Kenzo, Kopetz, Scott
Published in Investigational new drugs (01.02.2019)
Published in Investigational new drugs (01.02.2019)
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Phase I/II Study of DFP-10917 in Relapsed/Refractory AML Demonstrates Efficacy and Safety Profile Suitable for Phase III Study
Kantarjian, Hagop M., Jabbour, Elias J., Garcia-Manero, Guillermo, Kadia, Tapan M., DiNardo, Courtney D., Daver, Naval G., Borthakur, Gautam, Jain, Nitin, Waukau, Jane, Kwari, Monica, Anderson, Barry Douglas, Iizuka, Kenzo, Jin, Cheng, Zhang, Chun, Ravandi, Farhad, Plunkett, William
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Results of a Phase I/II Study of DFP-10917, a Nucleoside Analog, Given By Continuous Infusion (CI) in Patients (pts) with Relapsed or Refractory Acute Leukemia
Kantarjian, Hagop, Jabbour, Elias, Garcia-Manero, Guillermo, Kadia, Tapan, DiNardo, Courtney, Daver, Naval, Borthakur, Gautam, Jain, Nitin, Waukau, Jane, Kwari, Monica, Anderson, Barry Douglas, Iizuka, Kenzo, Jin, Cheng, Plunkett, William
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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First report of a phase I/II study of DFP-10917, a nucleoside analog, given by continuous infusion (CI) in patients (pts) with relapsed or refractory acute leukemia
Kantarjian, Hagop M., Jabbour, Elias, Garcia-Manero, Guillermo, Kadia, Tapan M., Dinardo, Courtney Denton, Daver, Naval Guastad, Borthakur, Gautam, Jain, Nitin, Waukau, Jane, Kwari, Monica, Anderson, Barry Douglas, Iizuka, Kenzo, Jin, Cheng, Plunkett, William
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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