Search Results - "IIMURA, SHIN" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of 3‑(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl‑3H‑imidazo[4,5‑b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

Discovery of 3‑(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl‑3H‑imidazo[4,5‑b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

by Lapierre, Jean-Marc, Eathiraj, Sudharshan, Vensel, David, Liu, Yanbin, Bull, Cathy O, Cornell-Kennon, Susan, Iimura, Shin, Kelleher, Eugene W, Kizer, Darin E, Koerner, Steffi, Makhija, Sapna, Matsuda, Akihisa, Moussa, Magdi, Namdev, Nivedita, Savage, Ronald E, Szwaya, Jeff, Volckova, Erika, Westlund, Neil, Wu, Hui, Schwartz, Brian
Published in Journal of medicinal chemistry (14.07.2016)

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Journal Article

Discovery of imidazo[1,2- b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models

Discovery of imidazo[1,2- b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models

by Shimizu, Hiroki, Yamasaki, Tomonori, Yoneda, Yoshiyuki, Muro, Fumihito, Hamada, Tomoaki, Yasukochi, Takanori, Tanaka, Shinji, Toki, Tadashi, Yokoyama, Mika, Morishita, Kaoru, Iimura, Shin
Published in Bioorganic & medicinal chemistry letters (01.08.2011)

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Journal Article

Discovery of imidazo[1,2- b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo

Discovery of imidazo[1,2- b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo

by Shimizu, Hiroki, Yasumatsu, Isao, Hamada, Tomoaki, Yoneda, Yoshiyuki, Yamasaki, Tomonori, Tanaka, Shinji, Toki, Tadashi, Yokoyama, Mika, Morishita, Kaoru, Iimura, Shin
Published in Bioorganic & medicinal chemistry letters (01.02.2011)

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Journal Article

Enantioselective Total Synthesis of Guanacastepene N Using an Uncommon 7-Endo Heck Cyclization as a Pivotal Step

Enantioselective Total Synthesis of Guanacastepene N Using an Uncommon 7-Endo Heck Cyclization as a Pivotal Step

by Iimura, Shin, Overman, Larry E, Paulini, Ralph, Zakarian, Armen
Published in Journal of the American Chemical Society (11.10.2006)

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Journal Article

A Novel Inhibitor of I-KappaB Kinase Beta Ameliorates Experimental Arthritis through Downregulation of Proinflammatory Cytokines in Arthritic Joints

A Novel Inhibitor of I-KappaB Kinase Beta Ameliorates Experimental Arthritis through Downregulation of Proinflammatory Cytokines in Arthritic Joints

by Tanaka, Shinji, Toki, Tadashi, Yokoyama, Mika, Shimizu, Hiroki, Yamasaki, Tomonori, Yoneda, Yoshiyuki, Muro, Fumihito, Yasukochi, Takanori, Iimura, Shin, Morishita, Kaoru
Published in Biological & pharmaceutical bulletin (01.01.2014)

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Journal Article

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

by Muro, Fumihito, Iimura, Shin, Sugimoto, Yuuichi, Yoneda, Yoshiyuki, Chiba, Jun, Watanabe, Toshiyuki, Setoguchi, Masaki, Iigou, Yutaka, Matsumoto, Keiko, Satoh, Atsushi, Takayama, Gensuke, Taira, Tomoe, Yokoyama, Mika, Takashi, Tohru, Nakayama, Atsushi, Machinaga, Nobuo
Published in Journal of medicinal chemistry (24.12.2009)

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Journal Article

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

by Setoguchi, Masaki, Iimura, Shin, Sugimoto, Yuuichi, Yoneda, Yoshiyuki, Chiba, Jun, Watanabe, Toshiyuki, Muro, Fumihito, Iigo, Yutaka, Takayama, Gensuke, Yokoyama, Mika, Taira, Tomoe, Aonuma, Misato, Takashi, Tohru, Nakayama, Atsushi, Machinaga, Nobuo
Published in Bioorganic & medicinal chemistry (01.02.2012)

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Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]pheny lacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist

Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]pheny lacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist

by Muro, Fumihito, Shin IImura, Shin IImura, Yoneda, Yoshiyuki, Chiba, Jun, Watanabe, Toshiyuki, Setoguchi, Masaki, Yutaka IIgou, Yutaka IIgou, Takayama, Gensuke, Yokoyama, Mika, Takashi, Tohru, Nakayama, Atsushi, Machinaga, Nobuo
Published in Bioorganic & medicinal chemistry (01.12.2008)

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Journal Article

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists

by Chiba, Jun, Iimura, Shin, Yoneda, Yoshiyuki, Watanabe, Toshiyuki, Muro, Fumito, Tsubokawa, Masao, Iigou, Yutaka, Satoh, Atsushi, Takayama, Gensuke, Yokoyama, Mika, Takashi, Tohru, Nakayama, Atsushi, Machinaga, Nobuo
Published in Bioorganic & medicinal chemistry (15.02.2007)

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Journal Article

4-(Pyrrolidinyl)methoxybenzoic Acid Derivatives as a Potent, Orally Active VLA-4 Antagonist

4-(Pyrrolidinyl)methoxybenzoic Acid Derivatives as a Potent, Orally Active VLA-4 Antagonist

by Chiba, Jun, Iimura, Shin, Yoneda, Yoshiyuki, Sugimoto, Yuichi, Horiuchi, Takao, Muro, Fumito, Ochiai, Yuichi, Ogasawara, Tomomi, Tsubokawa, Masao, Iigou, Yutaka, Takayama, Gensuke, Taira, Tomoe, Takata, Yoshimi, Yokoyama, Mika, Takashi, Tohru, Nakayama, Atsushi, Machinaga, Nobuo
Published in Chemical & Pharmaceutical Bulletin (2006)

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Journal Article

Synthesis and Structure-Activity Relationships of Novel 2', 2'-Difluoro Analogues of Docetaxel

Synthesis and Structure-Activity Relationships of Novel 2', 2'-Difluoro Analogues of Docetaxel

by UOTO, Kouichi, OHSUKI, Satoru, TAKENOSHITA, Haruhiro, ISHIYAMA, Takashi, IIMURA, Shin, HIROTA, Yasuhide, MITSUI, Ikuo, TERASAWA, Hirofumi, SOGA, Tsunehiko
Published in Chemical & pharmaceutical bulletin (01.11.1997)

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Journal Article

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity

by Taniguchi, Toru, Inagaki, Hiroaki, Baba, Daichi, Yasumatsu, Isao, Toyota, Akiko, Kaneta, Yasuyuki, Kiga, Masaki, Iimura, Shin, Odagiri, Takashi, Shibata, Yoshihiro, Ueda, Kiyono, Seo, Maki, Shimizu, Hiroki, Imaoka, Tomoki, Nakayama, Kiyoshi
Published in ACS medicinal chemistry letters (09.05.2019)

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Journal Article

Synthesis and antitumor activity of non-prodrug water-soluble taxoid: 10-C-aminoalkylated docetaxel analogs

Synthesis and antitumor activity of non-prodrug water-soluble taxoid: 10-C-aminoalkylated docetaxel analogs

by Iimura, S, Ohsuki, S, Chiba, J, Uoto, K, Iwahana, M, Terasawa, H, Soga, T
Published in Heterocycles (01.12.2000)

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Journal Article

A novel inhibitor stabilizes the inactive conformation of MAPK‐interacting kinase 1

A novel inhibitor stabilizes the inactive conformation of MAPK‐interacting kinase 1

by Matsui, Yumi, Yasumatsu, Isao, Yoshida, Ken-ichi, Iimura, Shin, Ikeno, Yutaka, Nawano, Takako, Fukano, Hajime, Ubukata, Osamu, Hanzawa, Hiroyuki, Tanzawa, Fumie, Isoyama, Takeshi
Published in Acta crystallographica. Section F, Structural biology communications (01.03.2018)

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Journal Article

Discovery of imidazo[1,2- b]pyridazine derivatives as IKKβ inhibitors. Part 1: Hit-to-lead study and structure–activity relationship

Discovery of imidazo[1,2- b]pyridazine derivatives as IKKβ inhibitors. Part 1: Hit-to-lead study and structure–activity relationship

by Shimizu, Hiroki, Tanaka, Shinji, Toki, Tadashi, Yasumatsu, Isao, Akimoto, Toshihiko, Morishita, Kaoru, Yamasaki, Tomonori, Yasukochi, Takanori, Iimura, Shin
Published in Bioorganic & medicinal chemistry letters (01.09.2010)

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Journal Article

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3 H -imidazo[4,5- b ]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3 H -imidazo[4,5- b ]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

by Lapierre, Jean-Marc, Eathiraj, Sudharshan, Vensel, David, Liu, Yanbin, Bull, Cathy O., Cornell-Kennon, Susan, Iimura, Shin, Kelleher, Eugene W., Kizer, Darin E., Koerner, Steffi, Makhija, Sapna, Matsuda, Akihisa, Moussa, Magdi, Namdev, Nivedita, Savage, Ronald E., Szwaya, Jeff, Volckova, Erika, Westlund, Neil, Wu, Hui, Schwartz, Brian
Published in Journal of medicinal chemistry (14.07.2016)

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Journal Article

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

by Setoguchi, Masaki, Iimura, Shin, Sugimoto, Yuuichi, Yoneda, Yoshiyuki, Chiba, Jun, Watanabe, Toshiyuki, Muro, Fumihito, Iigo, Yutaka, Takayama, Gensuke, Yokoyama, Mika, Taira, Tomoe, Aonuma, Misato, Takashi, Tohru, Nakayama, Atsushi, Machinaga, Nobuo
Published in Bioorganic & medicinal chemistry (01.01.2013)

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Journal Article

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid

by Muro, Fumihito, Iimura, Shin, Yoneda, Yoshiyuki, Chiba, Jun, Watanabe, Toshiyuki, Setoguchi, Masaki, Takayama, Gensuke, Yokoyama, Mika, Takashi, Tohru, Nakayama, Atsushi, Machinaga, Nobuo
Published in Bioorganic & medicinal chemistry (01.02.2009)

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Journal Article

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazo l yl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmeth o x y]cyclohexanecarboxylic acid

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazo l yl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmeth o x y]cyclohexanecarboxylic acid

by Setoguchi, Masaki, Iimura, Shin, Sugimoto, Yuuichi, Yoneda, Yoshiyuki, Chiba, Jun, Watanabe, Toshiyuki, Muro, Fumihito, Iigo, Yutaka, Takayama, Gensuke, Yokoyama, Mika, Taira, Tomoe, Aonuma, Misato, Takashi, Tohru, Nakayama, Atsushi, Machinaga, Nobuo
Published in Bioorganic & medicinal chemistry (01.01.2013)

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Journal Article

SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS

SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS

by ISOYAMA TAKESHI, HILL JASON, VENSEL DAVID, KOERNER STEFFI, BRASSARD CHRIS, YOSHIDA KENICHI, ASHWELL MARK A, MATSUDA AKIHISA, PALMA ROCIO, IIMURA SHIN, YAMAZAKI TAKANORI, FILIKOV ANTON, NAMDEV NIVEDITA, LAPIERRE JEAN MARC, TANDON MANISH, NICEWONGER ROBERT, KITAMURA TAKAHIRO, LIU YANBIN
Year of Publication 13.02.2019

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