Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor
Iikubo, Kazuhiko, Kondoh, Yutaka, Shimada, Itsuro, Matsuya, Takahiro, Mori, Kenichi, Ueno, Yoko, Okada, Minoru
Published in Chemical & pharmaceutical bulletin (2018)
Published in Chemical & pharmaceutical bulletin (2018)
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Journal Article
Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity
Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Terasaka, Tadashi, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Kikuchi, Aya, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.04.2022)
Published in Bioorganic & medicinal chemistry (01.04.2022)
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Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2
Kuriwaki, Ikumi, Kameda, Minoru, Hisamichi, Hiroyuki, Kikuchi, Shigetoshi, Iikubo, Kazuhiko, Kawamoto, Yuichiro, Moritomo, Hiroyuki, Kondoh, Yutaka, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Suzuki, Tomoyuki, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (15.05.2020)
Published in Bioorganic & medicinal chemistry (15.05.2020)
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Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors
Iikubo, Kazuhiko, Kurosawa, Kazuo, Matsuya, Takahiro, Kondoh, Yutaka, Kamikawa, Akio, Moritomo, Ayako, Iwai, Yoshinori, Tomiyama, Hiroshi, Shimada, Itsuro
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency
Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Kondoh, Yutaka, Terasaka, Tadashi, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Nakazawa, Taisuke, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.03.2021)
Published in Bioorganic & medicinal chemistry (01.03.2021)
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FUSED PYRIDAZINE DERIVATIVE
IIKUBO, Kazuhiko, IWAI, Yoshinori, WASHIO, Takuya, KOIZUMI, Yuka, TOMIYAMA, Hiroshi, INAGAKI, Yusuke, NAKAMURA, Akihiko, YAMASHITA, Yumi, TOYA, Hiroki
Year of Publication 02.05.2024
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Year of Publication 02.05.2024
Patent
Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists
Negoro, Kenji, Yonetoku, Yasuhiro, Moritomo, Ayako, Hayakawa, Masahiko, Iikubo, Kazuhiko, Yoshida, Shigeru, Takeuchi, Makoto, Ohta, Mitsuaki
Published in Bioorganic & medicinal chemistry (01.11.2012)
Published in Bioorganic & medicinal chemistry (01.11.2012)
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The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase
Iikubo, Kazuhiko, Ishikawa, Yuichi, Ando, Noritaka, Umezawa, Kazuo, Nishiyama, Shigeru
Published in Tetrahedron letters (07.01.2002)
Published in Tetrahedron letters (07.01.2002)
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IMIDAZO[1,2-A]PYRIDINE DERIVATIVE
OHMORI JUNYA, NI KENI, SAMIZU KIYOHIRO, MASUDA NAOYUKI, MITANI YASUYUKI, KOGANEMARU YOHEI, KAWANO NORIYUKI, IIKUBO KAZUHIKO
Year of Publication 26.06.2013
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Year of Publication 26.06.2013
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DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND
MATSUYA TAKAHIRO, TOMIYAMA HIROSHI, KONDOH YUTAKA, KUROSAWA KAZUO, IIKUBO KAZUHIKO, SHIMADA ITSURO, KAMIKAWA AKIO, IWAI YOSHINORI
Year of Publication 20.01.2012
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Year of Publication 20.01.2012
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NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
ASAUMI MAKOTO, OKADA HARUKI, KAWAMOTO YUICHIRO, KAMEDA MINORU, KURIWAKI IKUMI, MIYASAKA KOZO, MORITOMO HIROYUKI, SUZUKI ATSUSHI, FUTAMI TAKASHI, TSUNOYAMA KAZUHISA, TOKUZAKI KAZUO, SUZUKI TOMOYUKI, TOMIYAMA HIROSHI, NODA ATSUSHI, IIKUBO KAZUHIKO, HISAMICHI HIROYUKI, IWAI YOSHINORI
Year of Publication 06.11.2014
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Year of Publication 06.11.2014
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DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND
TOMIYAMA, HIROSHI, MATSUYA, TAKAHIRO, KONDOH, YUTAKA, SHIMADA, ITSURO, IIKUBO, KAZUHIKO, KAMIKAWA, AKIO, IWAI, YOSHINORI, KUROSAWA, KAZUO
Year of Publication 11.11.2010
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Year of Publication 11.11.2010
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IMIDAZO[1,2-a]PYRIDINE DERIVATIVE
MASUDA, NAOYUKI, SAMIZU, KIYOHIRO, MITANI, YASUYUKI, KAWANO, NORIYUKI, KOGANEMARU, YOHEI, IIKUBO, KAZUHIKO, OHMORI, JUNYA, NI, KENI
Year of Publication 03.11.2011
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Year of Publication 03.11.2011
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NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
OKADA, HARUKI, ASAUMI, MAKOTO, TOMIYAMA, HIROSHI, KURIWAKI, IKUMI, KAMEDA, MINORU, NODA, ATSUSHI, MIYASAKA, KOZO, IWAI, YOSHINORI, TOKUZAKI, KAZUO, HISAMICHI, HIROYUKI, KAWAMOTO, YUICHIRO, SUZUKI, ATSUSHI, TSUNOYAMA, KAZUHISA, IIKUBO, KAZUHIKO, FUTAMI, TAKASHI, SUZUKI, TOMOYUKI, MORITOMO, HIROYUKI
Year of Publication 06.09.2013
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Year of Publication 06.09.2013
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ARYLAMINOHETEROCYCLIC CARBOXAMIDE COMPOUND
ASAUMI, MAKOTO, TOMIYAMA, HIROSHI, MATSUYA, TAKAHIRO, SANO, YORIKATA, SHIMADA, ITSURO, KAMIKAWA, AKIO, YAMANAKA, AYA, IWAI, YOSHINORI, SHINDOU, NOBUAKI, KAWASE, TATSUYA, NISHIMURA, KOUICHI, IIKUBO, KAZUHIKO, FUTAMI, TAKASHI, KUROSAWA, KAZUO, KUROMITSU, SADAO
Year of Publication 26.04.2012
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Year of Publication 26.04.2012
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DI(ARYLAMINO)ARYL COMPOUND
FURUTANI TAKASHI, MATSUYA TAKAHIRO, MANO HIROYUKI, KONDOH YUTAKA, IIKUBO KAZUHIKO, KUROSAWA KAZUO, SHINDO NOBUAKI, SOGA TAKATOSHI, SHIMADA ITSURO, KUROMITSU SADAO, KAMIKAWA AKIO
Year of Publication 12.03.2010
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Year of Publication 12.03.2010
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DI(ARYLAMINO)ARYL COMPOUND
SHINDO, NOBUAKI, MATSUYA, TAKAHIRO, KONDOH, YUTAKA, SOGA, TAKATOSHI, SHIMADA, ITSURO, MANO, HIROYUKI, IIKUBO, KAZUHIKO, FURUTANI, TAKASHI, KAMIKAWA, AKIO, KUROSAWA, KAZUO, KUROMITSU, SADAO
Year of Publication 15.01.2009
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Year of Publication 15.01.2009
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PYRIMIDINE DERIVATIVE FUSED WITH NONAROMATIC RING
YOSHIDA, SHIGERU, NIGAWARA, TAKAHIRO, ONDA, KENICHI, HAYAKAWA, MASAHIKO, NEGORO, KENJI, YONETOKU, YASUHIRO, IIKUBO, KAZUHIKO, MORITOMO, HIROYUKI, SASUGA, DAISUKE, OHISHI, TAKAHIDE
Year of Publication 27.04.2006
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Year of Publication 27.04.2006
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AROMATIC-RING-FUSED PYRIMIDINE DERIVATIVE
YOSHIDA, SHIGERU, NIGAWARA, TAKAHIRO, ONDA, KENICHI, HAYAKAWA, MASAHIKO, NEGORO, KENJI, YONETOKU, YASUHIRO, IIKUBO, KAZUHIKO, MORITOMO, HIROYUKI, SASUGA, DAISUKE, OHISHI, TAKAHIDE
Year of Publication 20.04.2006
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Year of Publication 20.04.2006
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