Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant
Kopka, Ihor E., Lin, Linus S., Jewell, James P., Lanza, Thomas J., Fong, Tung M., Shen, Chun-Pyn, Lao, Zhege J., Ha, Sookhee, Castonguay, Laurie G., Van der Ploeg, Lex, Goulet, Mark T., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Journal Article
N-(Arylacetyl)-biphenylalanines as Potent VLA-4 Antagonists
Li, Bing, de Laszlo, Stephen E, Kamenecka, Theodore M, Kopka, Ihor E, Durette, Philippe L, Lanza, Jr, Thomas, MacCoss, Malcolm, Tong, Sharon, Mumford, Richard A, McCauley, Ermengilda D, Van Riper, Gail, Schmidt, John A, Hagmann, William K
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
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Journal Article
Inhibition of Stromelysin-1 (MMP-3) by P1‘-Biphenylylethyl Carboxyalkyl Dipeptides
Esser, Craig K, Bugianesi, Robert L, Caldwell, Charles G, Chapman, Kevin T, Durette, Philippe L, Girotra, Narindar N, Kopka, Ihor E, Lanza, Thomas J, Levorse, Dorothy A, MacCoss, Malcolm, Owens, Karen A, Ponpipom, Mitree M, Simeone, Joseph P, Harrison, Richard K, Niedzwiecki, Lisa, Becker, Joseph W, Marcy, Alice I, Axel, Melinda G, Christen, Amy J, McDonnell, Joseph, Moore, Vernon L, Olszewski, Julie M, Saphos, Cheryl, Visco, Denise M, Shen, Frank, Colletti, Adria, Krieter, Philip A, Hagmann, William K
Published in Journal of medicinal chemistry (14.03.1997)
Published in Journal of medicinal chemistry (14.03.1997)
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Journal Article
Substituted N-(3,5-Dichlorobenzenesulfonyl)- l-prolyl-phenylalanine analogues as potent VLA-4 antagonists
Kopka, Ihor E, Young, David N, Lin, Linus S, Mumford, Richard A, Magriotis, Plato A, MacCoss, Malcolm, Mills, Sander G, Riper, Gail Van, McCauley, Ermengilda, Egger, Linda E, Kidambi, Usha, Schmidt, John A, Lyons, Kathryn, Stearns, Ralph, Vincent, Stella, Colletti, Adria, Wang, Zhen, Tong, Sharon, Wang, Junying, Zheng, Song, Owens, Karen, Levorse, Dorothy, Hagmann, William K
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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Journal Article
The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists
Hagmann, William K, Durette, Philippe L, Lanza, Thomas, Kevin, Nancy Jo, de Laszlo, Stephen E, Kopka, Ihor E, Young, David, Magriotis, Plato A, Li, Bing, Lin, Linus S, Yang, Ginger, Kamenecka, Theodore, Chang, Linda L, Wilson, Jonathan, MacCoss, Malcolm, Mills, Sander G, Van Riper, Gail, McCauley, Ermengilda, Egger, Linda A, Kidambi, Usha, Lyons, Kathryn, Vincent, Stella, Stearns, Ralph, Colletti, Adria, Teffera, Johannes, Tong, Sharon, Fenyk-Melody, Judy, Owens, Karen, Levorse, Dorothy, Kim, Philip, Schmidt, John A, Mumford, Richard A
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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Journal Article
Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists
Kopka, Ihor E, Lin, Linus S, Mumford, Richard A, Lanza, Thomas, Magriotis, Plato A, Young, David, DeLaszlo, Stephen E, MacCoss, Malcolm, Mills, Sander G, Van Riper, Gail, McCauley, Ermengilda, Lyons, Kathryn, Vincent, Stella, Egger, Linda A, Kidambi, Usha, Stearns, Ralph, Colletti, Adria, Teffera, Yohannes, Tong, Sharon, Owens, Karen, Levorse, Dorothy, Schmidt, John A, Hagmann, William K
Published in Bioorganic & medicinal chemistry letters (02.09.2002)
Published in Bioorganic & medicinal chemistry letters (02.09.2002)
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Journal Article
The Discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists
Lin, Linus S., Kopka, Ihor E., Mumford, Richard A., Magriotis, Plato A., Lanza, Thomas, Durette, Philippe L., Kamenecka, Theodore, Young, David N., Laszlo, Stephen E.de, McCauley, Ermenegilda, Riper, Gail Van, Kidambi, Usha, Egger, Linda A., Tong, Xinchun, Lyons, Kathryn, Vincent, Stella, Stearns, Ralph, Colletti, Adria, Teffera, Yohannes, Fenyk-Melody, Judy, Schmidt, John A., MacCoss, Malcolm, Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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Journal Article
Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides
Chapman, Kevin T, Kopka, Ihor E, Durette, Philippe L, Esser, Craig K, Lanza, Thomas J, Izquierdo-Martin, Maria, Niedzwiecki, Lisa, Chang, Benedict, Harrison, Richard K
Published in Journal of medicinal chemistry (24.12.1993)
Published in Journal of medicinal chemistry (24.12.1993)
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Journal Article
Characterization of zinc-binding sites in human stromelysin-1: stoichiometry of the catalytic domain and identification of a cysteine ligand in the proenzyme
Salowe, Scott P, Marcy, Alice I, Cuca, Gregory C, Smith, Catherine K, Kopka, Ihor E, Hagmann, William K, Hermes, Jeffrey D
Published in Biochemistry (Easton) (19.05.1992)
Published in Biochemistry (Easton) (19.05.1992)
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Journal Article
2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis
Hammond, Milton L, Kopka, Ihor E, Zambias, Robert A, Caldwell, Charles G, Boger, Joshua, Baker, Florence, Bach, Tom, Luell, Silvi, MacIntyre, D. Euan
Published in Journal of medicinal chemistry (01.05.1989)
Published in Journal of medicinal chemistry (01.05.1989)
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Journal Article
Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5-benzofuranol, a potent topical antiinflammatory agent
Hammond, Milton L, Zambias, Robert A, Chang, Michael N, Jensen, Norman P, McDonald, John, Thompson, Kathryn, Boulton, David A, Kopka, Ihor E, Hand, Karen M
Published in Journal of medicinal chemistry (01.03.1990)
Published in Journal of medicinal chemistry (01.03.1990)
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Journal Article
Preparation of hindered lithium amide bases and rates of their reaction with ether solvents
Kopka, Ihor E, Fataftah, Zacharia A, Rathke, Michael W
Published in Journal of organic chemistry (01.02.1987)
Published in Journal of organic chemistry (01.02.1987)
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Journal Article
A convenient synthesis of 4-tert-butyl-5-benzofuranols and dihydrobenzofuranols
Zambias, Robert A, Caldwell, Charles G, Kopka, Ihor E, Hammond, Milton L
Published in Journal of organic chemistry (01.08.1988)
Published in Journal of organic chemistry (01.08.1988)
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Journal Article
Preparation of a series of highly hindered secondary amines, including bis(triethylcarbinyl)amine
Kopka, Ihor E, Fataftah, Zacharia A, Rathke, Michael W
Published in Journal of organic chemistry (01.11.1980)
Published in Journal of organic chemistry (01.11.1980)
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Journal Article
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases
Hagmann, William K, Caldwell, Charles G, Chen, Ping, Durette, Philippe L, Esser, Craig K, Lanza, Thomas J, Kopka, Ihor E, Guthikonda, Ravi, Shah, Shrenik K, MacCoss, Malcolm, Chabin, Renee M, Fletcher, Daniel, Grant, Stephan K, Green, Barbara G, Humes, John L, Kelly, Theresa M, Luell, Sylvie, Meurer, Roger, Moore, Vernon, Pacholok, Stephen G, Pavia, Tony, Williams, Hollis R, Wong, Kenny K
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
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Journal Article
Inhibition of stromelysin-1 (MMP-3) by P-1'-biphenylylethyl carboxyalkyl dipeptides
Esser, CK, Bugianesi, RL, Caldwell, CG, Chapman, KT, Durette, PL, Girotra, NN, Kopka, IE, Lanza, TJ, Levorse, DA, MacCoss, M, Owens, KA, Ponpipom, MM, Simeone, JP, Harrison, RK, Niedzwiecki, L, Becker, JW, Marcy, AI, Axel, MG, Christen, AJ, McDonnell, J, Moore, VL, Olszewski, JM, Saphos, C, Visco, DM, Shen, F, Colletti, A, Krieter, PA, Hagmann, WK
Published in Journal of medicinal chemistry (14.03.1997)
Published in Journal of medicinal chemistry (14.03.1997)
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Journal Article
Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow
Egger, Linda A, Kidambi, Usha, Cao, Jin, Van Riper, Gail, McCauley, Ermengilda, Mumford, Richard A, Amo, Suzanne, Lingham, Russell, Lanza, Thomas, Lin, Linus S, De Laszlo, Stephen E, Young, David N, Kopka, Ihor E, Tong, Sharon, Pikounis, Bill, Benson, Evelyn, Warwood, Sarah, Bargatze, Robert F, Hagmann, William K, Schmidt, John A, Detmers, Patricia A
Published in The Journal of pharmacology and experimental therapeutics (01.07.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2002)
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Journal Article
α 4 β 7 /α 4 β 1 Dual Integrin Antagonists Block α 4 β 7 -Dependent Adhesion under Shear Flow
Egger, Linda A., Kidambi, Usha, Cao, Jin, Van Riper, Gail, McCauley, Ermengilda, Mumford, Richard A., Amo, Suzanne, Lingham, Russell, Lanza, Thomas, Lin, Linus S., de Laszlo, Stephen E., Young, David N., Kopka, Ihor E., Tong, Sharon, Pikounis, Bill, Benson, Evelyn, Warwood, Sarah, Bargatze, Robert F., Hagmann, William K., Schmidt, John A., Detmers, Patricia A.
Published in The Journal of pharmacology and experimental therapeutics (01.07.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2002)
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Journal Article
CorrigendumCorrigendum to “The discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists”[Bioorg. Med. Chem. Lett. 12 (2002) 611]
Lin, Linus S, Kopka, Ihor E, Mumford, Richard A, Magriotis, Plato A, Lanza, Jr, Thomas, Durette, Philippe L, Kamenecka, Theodore, Young, David N, de Laszlo, Stephen E, McCauley, Ermenegilda, Van Riper, Gail, Kidambi, Usha, Egger, Linda A, Tong, Xinchun, Lyons, Kathryn, Vincent, Stella, Stearns, Ralph, Colletti, Adria, Teffera, Yohannes, Fenyk-Melody, Judy, Schmidt, John A, MacCoss, Malcolm, Hagmann, William K
Published in Bioorganic & medicinal chemistry letters (01.06.2002)
Published in Bioorganic & medicinal chemistry letters (01.06.2002)
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Journal Article