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Published in Journal of medicinal chemistry (11.09.2003)
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Identification of a novel series of selective 5-HT7 receptor antagonists
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5-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor
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3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
Smith, David G., Buffet, Marianne, Fenwick, Ashley E., Haigh, David, Ife, Robert J., Saunders, Martin, Slingsby, Brian P., Stacey, Rachel, Ward, Robert W.
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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The identification of clinical candidate SB-480848 : A potent inhibitor of lipoprotein-associated phospholipase A2
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Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-Substituted-4-(phenylamino)quinolines
Ife, Robert J, Brown, Thomas H, Keeling, David J, Leach, Colin A, Meeson, Malcolm L, Parsons, Michael E, Reavill, David R, Theobald, Colin J, Wiggall, Kenneth J
Published in Journal of medicinal chemistry (01.09.1992)
Published in Journal of medicinal chemistry (01.09.1992)
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SB-656104-A: A novel 5-HT7 receptor antagonist with improved in vivo properties
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Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Conformationally Restricted Indolopiperidine Derivatives as Potent CCR2B Receptor Antagonists
Witherington, Jason, Bordas, Vincent, Cooper, Dave G., Forbes, Ian T., Gribble, Andrew D., Ife, Robert J., Berkhout, Theo, Gohil, Jayneeta, Groot, Pieter H.E.
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-associated phospholipase A2 for evaluation in man
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Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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5-Aryl-pyrazolo[3,4- b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Haigh, David, Hickey, Deirdre M.B, Ife, Robert J, Rawlings, Anthony D, Slingsby, Brian P, Smith, David G, Ward, Robert W
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
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CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound
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Published in Bioorganic & medicinal chemistry letters (21.08.2000)
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
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Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K
FENWICK, Ashley E, GARNIER, Bénédicte, GRIBBLE, Andrew D, IFE, Robert J, RAWLINGS, Anthony D, WITHERINGTON, Jason
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2
BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
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1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2
BLOOMER, Jackie C, BOYD, Helen F, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A
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Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
BOYD, Helen F, HAMMOND, Beverley, STANSFIELD, Ian G, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines
Ife, Robert J, Brown, Thomas H, Blurton, Peter, Keeling, David J, Leach, Colin A, Meeson, Malcolm L, Parsons, Michael E, Theobald, Colin J
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3R,5S)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo
Gribble, Andrew D, Ife, Robert J, Shaw, Antony, McNair, David, Novelli, Christine E, Bakewell, Susan, Shah, Virendra P, Dolle, Roland E, Groot, Pieter H, Pearce, Nigel, Yates, John, Tew, David, Boyd, Helen, Ashman, Stephen, Eggleston, Drake S, Haltiwanger, R. Curtis, Okafo, George
Published in Journal of medicinal chemistry (10.09.1998)
Published in Journal of medicinal chemistry (10.09.1998)
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