Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors
Blake, James F, Xu, Rui, Bencsik, Josef R, Xiao, Dengming, Kallan, Nicholas C, Schlachter, Stephen, Mitchell, Ian S, Spencer, Keith L, Banka, Anna L, Wallace, Eli M, Gloor, Susan L, Martinson, Matthew, Woessner, Richard D, Vigers, Guy P.A, Brandhuber, Barbara J, Liang, Jun, Safina, Brian S, Li, Jun, Zhang, Birong, Chabot, Christine, Do, Steven, Lee, Leslie, Oeh, Jason, Sampath, Deepak, Lee, Brian B, Lin, Kui, Liederer, Bianca M, Skelton, Nicholas J
Published in Journal of medicinal chemistry (27.09.2012)
Published in Journal of medicinal chemistry (27.09.2012)
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Journal Article
Discovery of pyrrolopyrimidine inhibitors of Akt
Blake, James F., Kallan, Nicholas C., Xiao, Dengming, Xu, Rui, Bencsik, Josef R., Skelton, Nicholas J., Spencer, Keith L., Mitchell, Ian S., Woessner, Richard D., Gloor, Susan L., Risom, Tyler, Gross, Stefan D., Martinson, Matthew, Morales, Tony H., Vigers, Guy P.A., Brandhuber, Barbara J.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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Journal Article
Discovery and SAR of spirochromane Akt inhibitors
Kallan, Nicholas C., Spencer, Keith L., Blake, James F., Xu, Rui, Heizer, Justin, Bencsik, Josef R., Mitchell, Ian S., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Journal Article
Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
Bencsik, Josef R., Xiao, Dengming, Blake, James F., Kallan, Nicholas C., Mitchell, Ian S., Spencer, Keith L., Xu, Rui, Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Woessner, Richard D., Dizon, Faith, Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J., Prior, Wei Wei, Murray, Lesley J.
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
A total synthesis of the antitumour macrolide rhizoxin D
Mitchell, IS, Pattenden, G, Stonehouse, J
Published in Organic & biomolecular chemistry (21.12.2005)
Published in Organic & biomolecular chemistry (21.12.2005)
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Journal Article
PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitors
Escobar, Miguel, Luck, James, Averianov, Yevhenii, Ducore, Jonathan, Fernández, Maria Fernanda López, Giermasz, Adam, Hart, Daniel P., Journeycake, Janna, Kessler, Craig, Leissinger, Cindy, Mahlangu, Johnny, Martinez, Laura Villarreal, Miesbach, Wolfgang, Mitha, Ismail Haroon, Quon, Doris, Reding, Mark T., Schved, Jean‐François, Stasyshyn, Oleksandra, Vilchevska, Kateryna V., Wang, Michael, Windyga, Jerzy, Alexander, W. Allan, Al‐Sabbagh, Ahmad, Bonzo, Daniel, Mitchell, Ian S., Wilkinson, Thomas A., Hermans, Cédric
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.11.2021)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.11.2021)
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Journal Article
Eptacog beta efficacy and safety in the treatment and control of bleeding in paediatric subjects (<12 years) with haemophilia A or B with inhibitors
Pipe, Steven W., Hermans, Cédric, Chitlur, Meera, Carcao, Manuel, Castaman, Giancarlo, Davis, Joanna A., Ducore, Jonathan, Dunn, Amy L., Escobar, Miguel, Journeycake, Janna, Khan, Osman, Mahlangu, Johnny, Meeks, Shannon L., Mitha, Ismail Haroon, Négrier, Claude, Nowak‐Göttl, Ulrike, Recht, Michael, Chrisentery‐Singleton, Tammuella, Stasyshyn, Oleksandra, Vilchevska, Kateryna V., Martinez, Laura Villarreal, Wang, Michael, Windyga, Jerzy, Young, Guy, Alexander, W. Allan, Bonzo, Daniel, Macie, Christopher, Mitchell, Ian S., Sauty, Evelyne, Wilkinson, Thomas A., Shapiro, Amy D.
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.07.2022)
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01.07.2022)
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Journal Article
Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA
Xu, Rui, Banka, Anna, Blake, James F., Mitchell, Ian S., Wallace, Eli M., Bencsik, Josef R., Kallan, Nicholas C., Spencer, Keith L., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Journal Article
Eptacog Beta (rFVIIa) Has a Low Incidence of Spontaneous Rebleeding through 24 and 48 Hours in Adult and Adolescent Patients with Hemophilia A or B with Inhibitors
Dunn, Amy L., Dargaud, Yesim, Abajas, Yasmina L., Carcao, Manuel, Castaman, Giancarlo, Giermasz, Adam, Hermans, Cédric, Lewandowska, Magdalena D., Mahlangu, Johnny, Meeks, Shannon L., Miesbach, Wolfgang A., Recht, Michael, Salinas, Vanessa, Chrisentery-Singleton, Tammuella, Wang, Hongying, Mitchell, Ian S, Young, Guy
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
PERSEPT3: A Phase 3 Clinical Trial to Evaluate the Hemostatic Efficacy of Eptacog Beta (Recombinant Human FVIIa) in Perioperative Care in Subjects with Hemophilia Α or B with Inhibitors
Escobar, Miguel A., Quon, Doris, Leissinger, Cindy A., Luck, James V, Al-Sabbagh, Ahmad, Bonzo, Daniel, Mitchell, Ian S, Alexander, W Allan, Hermans, Cedric
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
In Vitro Evaluation of Thrombin Generation of Eptacog Beta (Factor VIIa, Recombinant) and Emicizumab in Congenital Hemophilia Α Plasma with and without Inhibitors
Pipe, Steven W., Recht, Michael, Callaghan, Michael U., Sidonio, Robert F., Grandoni, Jerry, Duretz, Veronique, Bonzo, Daniel, Plantier, Jean Luc, Evans, Sean, Mitchell, Ian S, Hermans, Cedric
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Single 225μg/Kg Dose Treatment with Eptacog Beta (Factor VIIa, Recombinant) Results in Rapid Hemostasis in Joint Bleeds for Persons with Hemophilia Α or Β with Inhibitors: A PERSEPT1 Subset Analysis
Journeycake, Janna M., Hermans, Cedric, Ducore, Jonathan M., Escobar, Miguel A., Young, Guy, Wang, Michael, Quon, Doris, Alexander, W Allan, Mitchell, Ian S, Al-Sabbagh, Ahmad, Bonzo, Daniel
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Eptacog Beta Efficacy in Children and Adolescents with Hemophilia A or B and Inhibitors: Subset Analysis Suggests Improved Caregiver Capacity to Assess Bleeding Episode Resolution with Subject Age
Young, Guy, Pipe, Steven W, Hermans, Cédric, Carcao, Manuel, Castaman, Giancarlo, Davis, Joanna A., Ducore, Jonathan M., Dunn, Amy L., Escobar, Miguel A., Journeycake, Janna, Khan, Osman, Mahlangu, Johnny, Meeks, Shannon, Mitha, Ismail Haroon, Négrier, Claude, Nowak-Göttl, Ulrike, Recht, Michael, Chrisentery-Singleton, Tammuella, Stasyshyn, Oleksandra, Vilchevska, Kateryna V., Villarreal Martinez, Laura, Wang, Michael, Windyga, Jerzy, Alexander, W. Allan, Al-Sabbagh, Ahmad, Bonzo, Daniel, Macie, Christopher, Mitchell, Ian S., Wilkinson, Thomas A., Shapiro, Amy D.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
5H-CYCLOPENTA[d]PYRIMIDINE AS AKT PROTEIN KINASE INHIBITOR
HENTEMANN MARTIN F, ANNA BANKA, BENCSIK JOSEF R, JAMES F BLAKE, LIANG JUN, STEPHEN T SCHLACHTER, RUI XU, IAN S MITCHELL, ELI M WALLACE, TONY P TANG, KALLEN NICHOLAS C
Year of Publication 15.01.2015
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Year of Publication 15.01.2015
Patent
HTRS2023.O8C.2 Eptacog beta efficacy and safety in underweight, normal weight, and overweight/obese persons with hemophilia A or B and inhibitors
Rafique, Amina, Srivastava, Alok, Abajas, Yasmina, Acharya, Suchitra, Ahuja, Sanjay, Román, María Teresa Álvarez, Carcao, Manuel, Dargaud, Yesim, Dunn, Amy, Hermans, Cédric, McGuinn, Catherine, Miesbach, Wolfgang, Reding, Mark T., Windyga, Jerzy, Bonzo, Daniel, Mitchell, Ian S., Wilkinson, Thomas A., Meeks, Shannon
Published in Research and practice in thrombosis and haemostasis (01.08.2023)
Published in Research and practice in thrombosis and haemostasis (01.08.2023)
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Journal Article
Evaluating DEER Distance Profiles in Terms of Protein Conformational Ensembles
Huang, Xi, de Vera, Ian S. Mitchell, Blackburn, Mandy E., Galiano, Luis, Fanucci, Gail E.
Published in Biophysical journal (28.01.2014)
Published in Biophysical journal (28.01.2014)
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Journal Article
A concise enantioselective total synthesis of rhizoxin D
Mitchell, Ian S., Pattenden, Gerald, Stonehouse, Jeffrey P.
Published in Tetrahedron letters (14.01.2002)
Published in Tetrahedron letters (14.01.2002)
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