Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry
Nadin, Alan, Hattotuwagama, Channa, Churcher, Ian
Published in Angewandte Chemie International Edition (27.01.2012)
Published in Angewandte Chemie International Edition (27.01.2012)
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Journal Article
Asymmetric Synthesis of Trisubstituted Aziridines via Aza-Darzens Reaction of Chiral Sulfinimines
Moragas, Toni, Churcher, Ian, Lewis, William, Stockman, Robert A.
Published in Organic letters (19.12.2014)
Published in Organic letters (19.12.2014)
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Journal Article
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D.
Published in Communications biology (20.03.2020)
Published in Communications biology (20.03.2020)
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Journal Article
Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines
Moragas, Toni, Liffey, Ryan M., Regentová, Dominika, Ward, Jon-Paul S., Dutton, Justine, Lewis, William, Churcher, Ian, Walton, Lesley, Souto, José A., Stockman, Robert A.
Published in Angewandte Chemie International Edition (16.08.2016)
Published in Angewandte Chemie International Edition (16.08.2016)
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Journal Article
Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines
Moragas, Toni, Liffey, Ryan M., Regentová, Dominika, Ward, Jon-Paul S., Dutton, Justine, Lewis, William, Churcher, Ian, Walton, Lesley, Souto, José A., Stockman, Robert A.
Published in Angewandte Chemie (16.08.2016)
Published in Angewandte Chemie (16.08.2016)
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Journal Article
Organic synthesis provides opportunities to transform drug discovery
Blakemore, David C., Castro, Luis, Churcher, Ian, Rees, David C., Thomas, Andrew W., Wilson, David M., Wood, Anthony
Published in Nature chemistry (01.04.2018)
Published in Nature chemistry (01.04.2018)
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Journal Article
The rise and rise of protein degradation: Opportunities and challenges ahead
Hughes, Scott J., Testa, Andrea, Thompson, Nicola, Churcher, Ian
Published in Drug discovery today (01.12.2021)
Published in Drug discovery today (01.12.2021)
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Journal Article
Catalytic in vivo protein knockdown by small-molecule PROTACs
Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M
Published in Nature chemical biology (01.08.2015)
Published in Nature chemical biology (01.08.2015)
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Journal Article
A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool
Colomer, Ignacio, Empson, Christopher J., Craven, Philip, Owen, Zachary, Doveston, Richard G., Churcher, Ian, Marsden, Stephen P., Nelson, Adam
Published in Chemical communications (Cambridge, England) (01.01.2016)
Published in Chemical communications (Cambridge, England) (01.01.2016)
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Journal Article
Optimization of a Series of RIPK2 PROTACs
Miah, Afjal H, Smith, Ian E. D, Rackham, Mark, Mares, Alina, Thawani, Aditya R, Nagilla, Rakesh, Haile, Pamela A, Votta, Bartholomew J, Gordon, Laurie J, Watt, Gillian, Denyer, Jane, Fisher, Don T, Dace, Phoebe, Giffen, Paul, Goncalves, Andrea, Churcher, Ian, Scott-Stevens, Paul, Harling, John D
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Journal Article
Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
Bassi, Zuni I, Fillmore, Martin C, Miah, Afjal H, Chapman, Trevor D, Maller, Claire, Roberts, Emma J, Davis, Lauren C, Lewis, Darcy E, Galwey, Nicholas W, Waddington, Kirsty E, Parravicini, Valentino, Macmillan-Jones, Abigail L, Gongora, Celine, Humphreys, Philip G, Churcher, Ian, Prinjha, Rab K, Tough, David F
Published in ACS chemical biology (19.10.2018)
Published in ACS chemical biology (19.10.2018)
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Journal Article
Structural Insights into PROTAC-Mediated Degradation of Bcl-xL
Chung, Chun-wa, Dai, Han, Fernandez, Esther, Tinworth, Christopher P, Churcher, Ian, Cryan, Jenni, Denyer, Jane, Harling, John D, Konopacka, Agnieszka, Queisser, Markus A, Tame, Christopher J, Watt, Gillian, Jiang, Fan, Qian, Dongming, Benowitz, Andrew B
Published in ACS chemical biology (18.09.2020)
Published in ACS chemical biology (18.09.2020)
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Journal Article
Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks
Foley, Daniel J., Craven, Philip G. E., Collins, Patrick M., Doveston, Richard G., Aimon, Anthony, Talon, Romain, Churcher, Ian, von Delft, Frank, Marsden, Stephen P., Nelson, Adam
Published in Chemistry : a European journal (26.10.2017)
Published in Chemistry : a European journal (26.10.2017)
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