Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions
Wen, Yao-Tseng, Huang, Ching-Wen, Liu, Chih-Peng, Chen, Chih-Hung, Tu, Chia-Mu, Hwang, Chrong-Shiong, Chen, Yi-Hsun, Chen, Wan-Ru, Lin, Keh-Liang, Ho, Yu-Chieh, Chen, Ta-Ching, Tsai, Rong-Kung
Published in Investigative ophthalmology & visual science (20.05.2021)
Published in Investigative ophthalmology & visual science (20.05.2021)
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Journal Article
The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models
Chen, Yi-Hsun, Lin, Wan-Ying, Huang, Yu Chuan, Ho, Wan Yu, Fu, Chih-Wei, Tu, Chia-Mu, Hwang, Chrong-Shiong, Hung, Chiu-Lien, Lin, Ming-Chun, Cheng, Felice, Wang, Yen-Jen, Chen, Chih-Hung, Chou, Shuen-Hsiang, She, Meng-Ping, Yang, Chia-Yi, Cheng, Hui-Ling, Liu, Chih-Peng, Lu, Da-Wen
Published in Investigative ophthalmology & visual science (18.10.2021)
Published in Investigative ophthalmology & visual science (18.10.2021)
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Journal Article
Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer
Hung, Chiu-Lien, Liu, Hao-Hsuan, Fu, Chih-Wei, Yeh, Hsun-Hao, Hu, Tsan-Lin, Kuo, Zong-Keng, Lin, Yu-Chin, Jhang, Mei-Ru, Hwang, Chrong-Shiong, Hsu, Hung-Chih, Kung, Hsing-Jien, Wang, Ling-Yu
Published in EBioMedicine (01.04.2023)
Published in EBioMedicine (01.04.2023)
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Journal Article
A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia
Hsu, Cherng-Ru, Chen, Yi-Hsun, Liu, Chih-Peng, Chen, Chih-Hung, Huang, Kuo-Kuei, Huang, Jui-Wen, Lin, Meng-Nan, Lin, Chih-Lung, Chen, Wan-Ru, Hsu, Yi-Ling, Lee, Tze-Chung, Chou, Shuen-Hsiang, Tu, Chia-Mu, Hwang, Chrong-Shiong, Huang, Yu Chuan, Lu, Da-Wen
Published in Investigative ophthalmology & visual science (01.02.2019)
Published in Investigative ophthalmology & visual science (01.02.2019)
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Journal Article
Pharmacophore modeling and virtual screening to identify potential RET kinase inhibitors
Shih, Kuei-Chung, Shiau, Chung-Wai, Chen, Ting-Shou, Ko, Ching-Huai, Lin, Chih-Lung, Lin, Chun-Yuan, Hwang, Chrong-Shiong, Tang, Chuan-Yi, Chen, Wan-Ru, Huang, Jui-Wen
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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Investigation of anti-leukemia molecular mechanism of ITR-284, a carboxamide analog, in leukemia cells and its effects in WEHI-3 leukemia mice
Wen, Yen-Fang, Yang, Jai-Sing, Kuo, Sheng-Chu, Hwang, Chrong-Shiong, Chung, Jing-Gung, Wu, Hsi-Chin, Huang, Wen-Wen, Jhan, Jia-Hua, Lin, Chung-Ming, Chen, Hui-Jye
Published in Biochemical pharmacology (01.02.2010)
Published in Biochemical pharmacology (01.02.2010)
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Synthesis and structure–activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors
Khanwelkar, Rahul R., Chen, Grace Shiahuy, Wang, Hsiao-Chun, Yu, Chao-Wu, Huang, Chiung-Hua, Lee, On, Chen, Chih-Hung, Hwang, Chrong-Shiong, Ko, Ching-Huai, Chou, Nien-Tzu, Lin, Mai-Wei, Wang, Ling-mei, Chen, Yen-Chun, Hseu, Tzong-Hsiung, Chang, Chia-Ni, Hsu, Hui-Chun, Lin, Hui-Chi, Shih, Ying-Chu, Chou, Shuen-Hsiang, Tseng, Hsiang-Wen, Liu, Chih-Peng, Tu, Chia-Mu, Hu, Tsan-Lin, Tsai, Yuan-Jang, Chern, Ji-Wang
Published in Bioorganic & medicinal chemistry (01.07.2010)
Published in Bioorganic & medicinal chemistry (01.07.2010)
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Journal Article
Design of Novel FLT-3 Inhibitors Based on Dual-Layer 3D-QSAR Model and Fragment-Based Compounds in Silico
Shih, Kuei-Chung, Lin, Chun-Yuan, Chi, Hsiao-Chieh, Hwang, Chrong-Shiong, Chen, Ting-Shou, Tang, Chuan-Yi, Hsiao, Nai-Wan
Published in Journal of chemical information and modeling (23.01.2012)
Published in Journal of chemical information and modeling (23.01.2012)
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Journal Article
Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors
Chen, Chih-Hung, Lee, On, Yao, Chung-Niang, Chuang, Meng-Yun, Chang, Yow-Lone, Chang, May-Hua, Wen, Yen-Fang, Yang, Wan-Hsu, Ko, Ching-Huai, Chou, Nien-Tzu, Lin, Mai-Wei, Lai, Chin-Pen, Sun, Chung-Yuan, Wang, Ling-mei, Chen, Yen-Chun, Hseu, Tzong-Hsiung, Chang, Chia-Ni, Hsu, Hui-Chun, Lin, Hui-Chi, Chang, Yu-Li, Shih, Ying-Chu, Chou, Shuen-Hsiang, Hsu, Yi-Ling, Tseng, Hsiang-Wen, Liu, Chih-Peng, Tu, Chia-Mu, Hu, Tsan-Lin, Tsai, Yuan-Jang, Chen, Ting-Shou, Lin, Chih-Lung, Chiou, Shu-Jiau, Liu, Chung-Cheng, Hwang, Chrong-Shiong
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Synthesis of 1-substituted 3-pyridinylmethylidenylindolin-2-ones and 1-substituted 3-quinolinylmethylidenylindolin-2-ones as the enhancers of ATRA-induced differentiation in HL-60 cells
Hung, Chi-Ying, Hsu, Mei-Hua, Huang, Li-Jiau, Hwang, Chrong-Shiong, Lee, On, Wu, Chen-Yi, Chen, Chih-Hung, Kuo, Sheng-Chu
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Journal Article
COMPOUNDS FOR INHIBITING AGC KINASE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
HUANG KUO-KUEI, CHEN YI-HSUN, HUANG JUI-WEN, HWANG CHRONG-SHIONG, CHIN SHIKO, LIU CHIH-PENG
Year of Publication 29.08.2019
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Year of Publication 29.08.2019
Patent
Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancerResearch in context
Chiu-Lien Hung, Hao-Hsuan Liu, Chih-Wei Fu, Hsun-Hao Yeh, Tsan-Lin Hu, Zong-Keng Kuo, Yu-Chin Lin, Mei-Ru Jhang, Chrong-Shiong Hwang, Hung-Chih Hsu, Hsing-Jien Kung, Ling-Yu Wang
Published in EBioMedicine (01.04.2023)
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Published in EBioMedicine (01.04.2023)
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Abstract B186: ITRI-2531 - A novel kinase inhibitor for treating hepatocellular carcinoma
Kuo, Tsung-Keng, Lee, On, Lin, Mai-Wei, Lin, Li-Zong, Liu, Chun-Min, Hsieh, Tai-ju, Wang, Chun-Chung, Lin, Shyh-Horng, Chang, Chia-Ni, Hsu, Hui-Chun, Chou, Nien-Tzu, Lai, Chin-Pen, Chen, Chih-Hung, Tu, Chia-Mu, Chen, Shih-Ta, Tsai, Yuan-Jang, Liu, Chih-Peng, Hwang, Jenn-Tsang, Huang, Jui-Wen, Chen, Yen-Chun, Hwang, Chrong-Shiong, Tseng, Hsiang-Wen
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract B26: Drug-Diagnostic co-development to target FLT3-ITD mutations in chemo-resistant acute myeloid leukemia cells
Ko, Ching-Huai, Ting-Shou, Chen, Mei-Wei, Lin, Chin-Pen, Lai, Wen-Hsun, Kuo, Chrong-Shiong, Hwang, Ling-Mei, Wang, SC, Tsai Jane
Published in Clinical cancer research (15.05.2012)
Published in Clinical cancer research (15.05.2012)
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Configurations of the isomeric 7-oxiranylbicyclo[4.2.0]octan-7-ols
Hwang, Chrong Shiong, Ward, Donald L, Reusch, William
Published in Journal of organic chemistry (01.09.1989)
Published in Journal of organic chemistry (01.09.1989)
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Journal Article
Abstract 728: Development of pharmacophore-based RET inhibitors for thyroid cancer therapy
Huang, Jui-wen, Ko, Ching-Huai, Chen, Ting-Shou, Lee, On, Tseng, Hsiang-Wen, Tsai, Yuan-Jang, Liu, Chih-Peng, Chen, Yen-Chun, Wang, Ling-Mei, Hwang, Chrong-Shiong
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Abstract 5781: ITRI-260, a new azaazulenone class kinase inhibitor, induces complete tumor regression and prolongs survival in AML mice
Lee, On, Liu, Hsingjin Eugene, Ko, Ching-Huai, Tsai, Yuan-Jang, Liu, Chih-Peng, Chen, Yen-Chun, Tseng, Hsiang-Wen, Shih, Ying-Chu, Chen, Ting-Shou, Chen, Chih-Hung, Chiou, Shu-Jiau, Wang, Ling-Mei, Hwang, Chrong-Shiong
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Abstract LB-160: ITRI-260, a promising candidate for treatment of acute myeloid leukemia
Liu, Chih-Peng, Liu, Hsingjin Eugene, Lee, On, Chen, Chih-Hung, Huang, Jui-Wen, Chen, Ting-Shou, Ko, Ching-Huai, Wang, Ling-Mei, Chen, Yen-Chun, Tseng, Hsiang-Wen, Shih, Ying-Chu, Chiou, Shu-Jiau, Tsai, Yuan-Jang, Hwang, Chrong-Shiong
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
ISOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATEMTN OF OPHTHALMIC DISORDERS
HWANG, Chrong-Shiong, CHEN, Chih-Hung, CHEN, Yi-Hsun, LIU, Chih-Peng, HUANG, Kuo-Kuei, HUANG, Jui-Wen
Year of Publication 18.10.2023
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Year of Publication 18.10.2023
Patent