The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands
Hutchinson, Sebastian, Foulon, Sophie, Crouzols, Aline, Menafra, Roberta, Rotureau, Brice, Griffiths, Andrew D, Bastin, Philippe
Published in PLoS pathogens (20.09.2021)
Published in PLoS pathogens (20.09.2021)
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Journal Article
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
Faria, Joana, Glover, Lucy, Hutchinson, Sebastian, Boehm, Cordula, Field, Mark C., Horn, David
Published in Nature communications (09.07.2019)
Published in Nature communications (09.07.2019)
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Journal Article
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes
Baker, Nicola, Graham Hamilton, Jonathan M. Wilkes, Sebastian Hutchinson, Michael P. Barrett, David Horn
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2015)
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Journal Article
Escaping the immune system by DNA repair and recombination in African trypanosomes
Sima, Núria, McLaughlin, Emilia Jane, Hutchinson, Sebastian, Glover, Lucy
Published in Open biology (01.11.2019)
Published in Open biology (01.11.2019)
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Journal Article
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Zhang, Ning, Zoltner, Martin, Leung, Ka-Fai, Scullion, Paul, Hutchinson, Sebastian, Del Pino, Ricardo C, Vincent, Isabel M, Zhang, Yong-Kang, Freund, Yvonne R, Alley, Michael R K, Jacobs, Robert T, Read, Kevin D, Barrett, Michael P, Horn, David, Field, Mark C
Published in PLoS pathogens (01.02.2018)
Published in PLoS pathogens (01.02.2018)
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Journal Article
Forward Genetics in African Trypanosomes
Hutchinson, Sebastian, Glover, Lucy
Published in Methods in molecular biology (Clifton, N.J.) (2020)
Published in Methods in molecular biology (Clifton, N.J.) (2020)
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Book Chapter
Journal Article
A post-transcriptional respiratome regulon in trypanosomes
Trenaman, Anna, Glover, Lucy, Hutchinson, Sebastian, Horn, David
Published in Nucleic acids research (26.07.2019)
Published in Nucleic acids research (26.07.2019)
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Journal Article
CRISPR in Parasitology: Not Exactly Cut and Dried
Bryant, Jessica M., Baumgarten, Sebastian, Glover, Lucy, Hutchinson, Sebastian, Rachidi, Najma
Published in Trends in parasitology (01.06.2019)
Published in Trends in parasitology (01.06.2019)
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Journal Article
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes
Mehnert, Ann-Kathrin, Prorocic, Marco, Dujeancourt-Henry, Annick, Hutchinson, Sebastian, McCulloch, Richard, Glover, Lucy
Published in Nucleic acids research (22.02.2021)
Published in Nucleic acids research (22.02.2021)
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Journal Article
Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei
Collett, Clare F, Kitson, Carl, Baker, Nicola, Steele-Stallard, Heather B, Santrot, Marie-Victoire, Hutchinson, Sebastian, Horn, David, Alsford, Sam
Published in Antimicrobial agents and chemotherapy (01.08.2019)
Published in Antimicrobial agents and chemotherapy (01.08.2019)
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Journal Article
Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects
Bonnefoy, Serge, Watson, Christopher M., Kernohan, Kristin D., Lemos, Moara, Hutchinson, Sebastian, Poulter, James A., Crinnion, Laura A., Berry, Ian, Simmonds, Jennifer, Vasudevan, Pradeep, O’Callaghan, Chris, Hirst, Robert A., Rutman, Andrew, Huang, Lijia, Hartley, Taila, Grynspan, David, Moya, Eduardo, Li, Chunmei, Carr, Ian M., Bonthron, David T., Leroux, Michel, Boycott, Kym M., Bastin, Philippe, Sheridan, Eamonn G.
Published in American journal of human genetics (01.11.2018)
Published in American journal of human genetics (01.11.2018)
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Journal Article
Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes
Glover, Lucy, Alsford, Sam, Baker, Nicola, Turner, Daniel J, Sanchez-Flores, Alejandro, Hutchinson, Sebastian, Hertz-Fowler, Christiane, Berriman, Matthew, Horn, David
Published in Nature protocols (01.01.2015)
Published in Nature protocols (01.01.2015)
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Journal Article
Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes
Faria, Joana, Luzak, Vanessa, Müller, Laura S. M., Brink, Benedikt G., Hutchinson, Sebastian, Glover, Lucy, Horn, David, Siegel, T. Nicolai
Published in Nature microbiology (01.03.2021)
Published in Nature microbiology (01.03.2021)
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Journal Article
Flagellar incorporation of proteins follows at least two different routes in trypanosomes
Vincensini, Laetitia, Blisnick, Thierry, Bertiaux, Eloïse, Hutchinson, Sebastian, Georgikou, Christina, Ooi, Cher‐Pheng, Bastin, Philippe
Published in Biology of the cell (01.02.2018)
Published in Biology of the cell (01.02.2018)
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Journal Article