Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574
Shaffer, Christopher L, Hurst, Raymond S, Scialis, Renato J, Osgood, Sarah M, Bryce, Dianne K, Hoffmann, William E, Lazzaro, John T, Hanks, Ashley N, Lotarski, Susan, Weber, Mark L, Liu, JianHua, Menniti, Frank S, Schmidt, Christopher J, Hajós, Mihály
Published in The Journal of pharmacology and experimental therapeutics (01.10.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2013)
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Discovery and Structure−Activity Relationship of Quinuclidine Benzamides as Agonists of α7 Nicotinic Acetylcholine Receptors
Bodnar, Alice L, Cortes-Burgos, Luz A, Cook, Karen K, Dinh, Dac M, Groppi, Vincent E, Hajos, Mihaly, Higdon, Nicole R, Hoffmann, William E, Hurst, Raymond S, Myers, Jason K, Rogers, Bruce N, Wall, Theron M, Wolfe, Mark L, Wong, Erik
Published in Journal of medicinal chemistry (24.02.2005)
Published in Journal of medicinal chemistry (24.02.2005)
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Transient and Progressive Electrophysiological Alterations in the Corticostriatal Pathway in a Mouse Model of Huntington's Disease
Cepeda, Carlos, Hurst, Raymond S, Calvert, Christopher R, Hernandez-Echeagaray, Elizabeth, Nguyen, Oanh K, Jocoy, Emily, Christian, Lindsey J, Ariano, Marjorie A, Levine, Michael S
Published in The Journal of neuroscience (01.02.2003)
Published in The Journal of neuroscience (01.02.2003)
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Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia
Cepeda, Carlos, Hurst, Raymond S., Flores-Hernández, Jorge, Hernández-Echeagaray, Elizabeth, Klapstein, Gloria J., Boylan, Marea K., Calvert, Christopher R., Jocoy, Emily L., Nguyen, Oanh K., André, Véronique M., Vinters, Harry V., Ariano, Marjorie A., Levine, Michael S., Mathern, Gary W.
Published in Journal of neuroscience research (15.05.2003)
Published in Journal of neuroscience research (15.05.2003)
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Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation
Rollema, Hans, Coe, Jotham W., Chambers, Leslie K., Hurst, Raymond S., Stahl, Stephen M., Williams, Kathryn E.
Published in Trends in pharmacological sciences (Regular ed.) (01.07.2007)
Published in Trends in pharmacological sciences (Regular ed.) (01.07.2007)
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Discovery of oxazoline enhancers of cellular progranulin release
Peng, Xiaowen, Lanter, James C., Y.-P. Chen, Angela, Brand, Morgan A., Wozniak, Mary K., Hoekman, Steven, Longin, Ondřej, Regeling, Hendrik, Zonneveld, Wim, P. L. Bell, Roel, Koenig, Gerhard, Hurst, Raymond S., Blain, Jean-François, Burnett, Duane A.
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
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Discovery and characterization of novel TRPML1 agonists
Peng, Xiaowen, Holler, Christopher J., Alves, Anna -Maria F., Oliviera, Michelle G., Speake, Michael, Pugliese, Angelo, Oskouei, Mina R., de Freitas, Ivan D., Chen, Angela Y. -P., Gallegos, Richard, McTighe, Stephanie M., Koenig, Gerhard, Hurst, Raymond S., Blain, Jean-Francois, Lanter, James C., Burnett, Duane A.
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
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Positive Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor: SAR Investigation Around PNU-120596
Acker, Brad A, Badescu, Valentina O, Berkenpas, Mitchell B, Groppi, Vincent E, Hajós, Mihaly, Higdon, Nicole R, Hurst, Raymond S, Jon Jacobsen, E, Margolis, Brandon J, McWhorter, William W, Myers, Jason K, Piotrowski, David W, Rogers, Bruce N, Sarapa, Dusan, Vetman, Tatiana N, Walker, Daniel P, Wall, Theron M, Wilhite, David M, Wishka, Donn G, Xu, Wenjian, Yates, Karen M
Published in Bioorganic & medicinal chemistry letters (01.09.2023)
Published in Bioorganic & medicinal chemistry letters (01.09.2023)
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Partial Agonists of the α3β4 Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats
CHATTERJEE, Susmita, STEENSLAND, Pia, SIMMS, Jeffrey A, HOLGATE, Joan, COE, Jotham W, HURST, Raymond S, SHAFFER, Christopher L, LOWE, John, ROLLEMA, Hans, BARTLETT, Selena E
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2011)
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2011)
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The Discovery and Characterization of the α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N‑{(3S,4S)‑4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)
Shaffer, Christopher L, Patel, Nandini C, Schwarz, Jacob, Scialis, Renato J, Wei, Yunjing, Hou, Xinjun J, Xie, Longfei, Karki, Kapil, Bryce, Dianne K, Osgood, Sarah M, Hoffmann, William E, Lazzaro, John T, Chang, Cheng, McGinnis, Dina F, Lotarski, Susan M, Liu, JianHua, Obach, R. Scott, Weber, Mark L, Chen, Laigao, Zasadny, Kenneth R, Seymour, Patricia A, Schmidt, Christopher J, Hajós, Mihály, Hurst, Raymond S, Pandit, Jayvardhan, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship
Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E. Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H. F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel alpha 7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O'Donnell, Christopher J., Rogers, Bruce N., Bronk, Brian S., Bryce, Dianne K., Coe, Jotham W., Cook, Karen K., Duplantier, Allen J., Evrard, Edelweiss, Hajos, Mihaly, Hoffmann, William E., Hurst, Raymond S., Maklad, Noha, Mather, Robert J., McLean, Stafford, Nedza, Frank M., O'Neill, Brian T., Peng, Langu, Qian, Weimin, Rottas, Melinda M., Sands, Steven B., Schmidt, Anne W., Shrikhande, Alka V., Spracklin, Douglas K., Wong, Diane F., Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators
Patel, Nandini C, Schwarz, Jacob, Hou, Xinjun J, Hoover, Dennis J, Xie, Longfei, Fliri, Anton J, Gallaschun, Randall J, Lazzaro, John T, Bryce, Dianne K, Hoffmann, William E, Hanks, Ashley N, McGinnis, Dina, Marr, Eric S, Gazard, Justin L, Hajós, Mihály, Scialis, Renato J, Hurst, Raymond S, Shaffer, Christopher L, Pandit, Jayvardhan, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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Journal Article
Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O’Donnell, Christopher J, Rogers, Bruce N, Bronk, Brian S, Bryce, Dianne K, Coe, Jotham W, Cook, Karen K, Duplantier, Allen J, Evrard, Edelweiss, Hajós, Mihaly, Hoffmann, William E, Hurst, Raymond S, Maklad, Noha, Mather, Robert J, McLean, Stafford, Nedza, Frank M, O’Neill, Brian T, Peng, Langu, Qian, Weimin, Rottas, Melinda M, Sands, Steven B, Schmidt, Anne W, Shrikhande, Alka V, Spracklin, Douglas K, Wong, Diane F, Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide as an agonist of the alpha 7 nicotinic acetylcholine receptor: In vitro and in vivo activity
Acker, Brad A, Jacobsen, EJon, Rogers, Bruce N, Wishka, Donn G, Reitz, Steven C, Piotrowski, David W, Myers, Jason K, Wolfe, Mark L, Groppi, Vincent E, Thornburgh, Bruce A, Tinholt, Paula M, Walters, Rodney R, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Krause, Michael, Li, Kai S, Hoffmann, William E, Hajos, Mihaly, Hurst, Raymond S, Walker, Daniel P
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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Therapeutic doses of antidepressants are projected not to inhibit human α4β2 nicotinic acetylcholine receptors
Weber, Mark L., Hofland, Corry M., Shaffer, Christopher L., Flik, Gunnar, Cremers, Thomas, Hurst, Raymond S., Rollema, Hans
Published in Neuropharmacology (01.09.2013)
Published in Neuropharmacology (01.09.2013)
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Journal Article
Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease
Levine, Michael S., Klapstein, Gloria J., Koppel, Ahrin, Gruen, Ehud, Cepeda, Carlos, Vargas, Mauricio E., Jokel, Eve S., Carpenter, Ellen M., Zanjani, Hadi, Hurst, Raymond S., Efstratiadis, Argiris, Zeitlin, Scott, Chesselet, Marie-Françoise
Published in Journal of neuroscience research (15.11.1999)
Published in Journal of neuroscience research (15.11.1999)
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Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha 7 nicotinic acetylcholine receptor agonists
Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, EJon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik HF, Rogers, Bruce N
Published in Bioorganic & medicinal chemistry (15.12.2006)
Published in Bioorganic & medicinal chemistry (15.12.2006)
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