Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19
Liu, Hengrui, Iketani, Sho, Zask, Arie, Khanizeman, Nisha, Bednarova, Eva, Forouhar, Farhad, Fowler, Brandon, Hong, Seo Jung, Mohri, Hiroshi, Nair, Manoj S, Huang, Yaoxing, Tay, Nicholas E S, Lee, Sumin, Karan, Charles, Resnick, Samuel J, Quinn, Colette, Li, Wenjing, Shion, Henry, Xia, Xin, Daniels, Jacob D, Bartolo-Cruz, Michelle, Farina, Marcelo, Rajbhandari, Presha, Jurtschenko, Christopher, Lauber, Matthew A, McDonald, Thomas, Stokes, Michael E, Hurst, Brett L, Rovis, Tomislav, Chavez, Alejandro, Ho, David D, Stockwell, Brent R
Published in Nature communications (07.04.2022)
Published in Nature communications (07.04.2022)
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High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity
Choi, Ryan, Zhou, Mowei, Shek, Roger, Wilson, Jesse W, Tillery, Logan, Craig, Justin K, Salukhe, Indraneel A, Hickson, Sarah E, Kumar, Neeraj, James, Rhema M, Buchko, Garry W, Wu, Ruilian, Huff, Sydney, Nguyen, Tu-Trinh, Hurst, Brett L, Cherry, Sara, Barrett, Lynn K, Hyde, Jennifer L, Van Voorhis, Wesley C
Published in PloS one (22.04.2021)
Published in PloS one (22.04.2021)
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Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity
Swanson, Michael D., Boudreaux, Daniel M., Salmon, Loïc, Chugh, Jeetender, Winter, Harry C., Meagher, Jennifer L., André, Sabine, Murphy, Paul V., Oscarson, Stefan, Roy, René, King, Steven, Kaplan, Mark H., Goldstein, Irwin J., Tarbet, E. Bart, Hurst, Brett L., Smee, Donald F., de la Fuente, Cynthia, Hoffmann, Hans-Heinrich, Xue, Yi, Rice, Charles M., Schols, Dominique, Garcia, J. Victor, Stuckey, Jeanne A., Gabius, Hans-Joachim, Al-Hashimi, Hashim M., Markovitz, David M.
Published in Cell (22.10.2015)
Published in Cell (22.10.2015)
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Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
Sanders, Brian C, Pokhrel, Suman, Labbe, Audrey D, Mathews, Irimpan I, Cooper, Connor J, Davidson, Russell B, Phillips, Gwyndalyn, Weiss, Kevin L, Zhang, Qiu, O'Neill, Hugh, Kaur, Manat, Schmidt, Jurgen G, Reichard, Walter, Surendranathan, Surekha, Parvathareddy, Jyothi, Phillips, Lexi, Rainville, Christopher, Sterner, David E, Kumaran, Desigan, Andi, Babak, Babnigg, Gyorgy, Moriarty, Nigel W, Adams, Paul D, Joachimiak, Andrzej, Hurst, Brett L, Kumar, Suresh, Butt, Tauseef R, Jonsson, Colleen B, Ferrins, Lori, Wakatsuki, Soichi, Galanie, Stephanie, Head, Martha S, Parks, Jerry M
Published in Nature communications (28.03.2023)
Published in Nature communications (28.03.2023)
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Anti‐SARS‐CoV‐2 activity of targeted kinase inhibitors: Repurposing clinically available drugs for COVID‐19 therapy
Boytz, RuthMabel, Słabicki, Mikołaj, Ramaswamy, Sita, Patten, J. J., Zou, Charles, Meng, Chengcheng, Hurst, Brett L., Wang, Jinhua, Nowak, Radosław P., Yang, Priscilla L., Sattler, Martin, Stone, Richard M., Griffin, James D., Gray, Nathanael S., Gummuluru, Suryaram, Davey, Robert A., Weisberg, Ellen
Published in Journal of medical virology (01.01.2023)
Published in Journal of medical virology (01.01.2023)
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An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models
Leekha, Ankita, Saeedi, Arash, Kumar, Monish, Sefat, K. M. Samiur Rahman, Martinez-Paniagua, Melisa, Meng, Hui, Fathi, Mohsen, Kulkarni, Rohan, Reichel, Kate, Biswas, Sujit, Tsitoura, Daphne, Liu, Xinli, Cooper, Laurence J. N., Sands, Courtney M., Das, Vallabh E., Sebastian, Manu, Hurst, Brett L., Varadarajan, Navin
Published in Nature communications (18.07.2024)
Published in Nature communications (18.07.2024)
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Visible blue light inhibits infection and replication of SARS-CoV-2 at doses that are well-tolerated by human respiratory tissue
Stasko, Nathan, Kocher, Jacob F., Annas, Abigail, Henson, Ibrahim, Seitz, Theresa S., Miller, Joy M., Arwood, Leslee, Roberts, Rachel C., Womble, Thomas M., Keller, Emily G., Emerson, Soren, Bergmann, Michael, Sheesley, Ashley N. Y., Strong, Rebecca J., Hurst, Brett L., Emerson, David, Tarbet, E. Bart, Bradrick, Shelton S., Cockrell, Adam S.
Published in Scientific reports (18.10.2021)
Published in Scientific reports (18.10.2021)
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Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice
Morrey, John D, Wang, Hong, Hurst, Brett L, Zukor, Katherine, Siddharthan, Venkatraman, Van Wettere, Arnaud J, Sinex, Donal G, Tarbet, E Bart
Published in Viruses (12.01.2018)
Published in Viruses (12.01.2018)
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Effects of the Combination of Favipiravir (T-705) and Oseltamivir on Influenza A Virus Infections in Mice
SMEE, Donald F, HURST, Brett L, WONG, Min-Hui, BAILEY, Kevin W, BART TARBET, E, MORREY, John D, FURUTA, Yousuke
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
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Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV‑2 and Potential Mechanisms
Puhl, Ana C, Fritch, Ethan J, Lane, Thomas R, Tse, Longping V, Yount, Boyd L, Sacramento, Carolina Q, Fintelman-Rodrigues, Natalia, Tavella, Tatyana Almeida, Maranhão Costa, Fabio Trindade, Weston, Stuart, Logue, James, Frieman, Matthew, Premkumar, Lakshmanane, Pearce, Kenneth H, Hurst, Brett L, Andrade, Carolina Horta, Levi, James A, Johnson, Nicole J, Kisthardt, Samantha C, Scholle, Frank, Souza, Thiago Moreno L, Moorman, Nathaniel John, Baric, Ralph S, Madrid, Peter B, Ekins, Sean
Published in ACS omega (23.03.2021)
Published in ACS omega (23.03.2021)
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Effects of Double Combinations of Amantadine, Oseltamivir, and Ribavirin on Influenza A (H5N1) Virus Infections in Cell Culture and in Mice
SMEE, Donald F, HURST, Brett L, WONG, Min-Hui, BAILEY, Kevin W, MORREY, John D
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
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TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model
Maio, Nunziata, Cherry, Sara, Schultz, David C., Hurst, Brett L., Linehan, W. Marston, Rouault, Tracey A.
Published in iScience (21.10.2022)
Published in iScience (21.10.2022)
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In vitro activity of favipiravir and neuraminidase inhibitor combinations against oseltamivir-sensitive and oseltamivir-resistant pandemic influenza A (H1N1) virus
Tarbet, E. Bart, Vollmer, Almut H, Hurst, Brett L, Barnard, Dale L, Furuta, Yousuke, Smee, Donald F
Published in Archives of virology (01.06.2014)
Published in Archives of virology (01.06.2014)
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Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses
Smee, Donald F, Wong, Min-Hui, Hurst, Brett L, Ennis, Jane, Turner, Jeffrey D
Published in PloS one (09.07.2013)
Published in PloS one (09.07.2013)
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Trivalent Subunit Vaccine Candidates for COVID-19 and Their Delivery Devices
Ortega-Rivera, Oscar A, Shin, Matthew D, Chen, Angela, Beiss, Veronique, Moreno-Gonzalez, Miguel A, Lopez-Ramirez, Miguel A, Reynoso, Maria, Wang, Hong, Hurst, Brett L, Wang, Joseph, Pokorski, Jonathan K, Steinmetz, Nicole F
Published in Journal of the American Chemical Society (15.09.2021)
Published in Journal of the American Chemical Society (15.09.2021)
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An Advax-CpG adjuvanted recombinant H5 hemagglutinin vaccine protects mice against lethal influenza infection
Honda-Okubo, Yoshikazu, Bart Tarbet, E, Hurst, Brett L, Petrovsky, Nikolai
Published in Vaccine (07.09.2023)
Published in Vaccine (07.09.2023)
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Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A viruses
Tao, Wenqian, Hurst, Brett L., Shakya, Akhilesh Kumar, Uddin, Md Jasim, Ingrole, Rohan S.J., Hernandez-Sanabria, Mayra, Arya, Ravi P., Bimler, Lynn, Paust, Silke, Tarbet, E. Bart, Gill, Harvinder Singh
Published in Antiviral research (01.05.2017)
Published in Antiviral research (01.05.2017)
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Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles
Stinson, Jordan A., Boopathy, Archana V., Cieslewicz, Brian M., Zhang, Yichen, Hartman, Nickolas W., Miller, David P., Dirckx, Matthew, Hurst, Brett L., Tarbet, E. Bart, Kluge, Jonathan A., Kosuda, Kathryn M.
Published in Vaccine (07.09.2021)
Published in Vaccine (07.09.2021)
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An Advax-CpG55.2 adjuvanted recombinant hemagglutinin vaccine provides immunity against H7N9 influenza in adult and neonatal mice
Honda-Okubo, Yoshikazu, Sakala, Isaac G., André, Greiciely, Tarbet, E. Bart, Hurst, Brett L., Petrovsky, Nikolai
Published in Vaccine (31.08.2023)
Published in Vaccine (31.08.2023)
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A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV‑2 Infection of Human and Monkey Cells
Mellott, Drake M, Tseng, Chien-Te, Drelich, Aleksandra, Fajtová, Pavla, Chenna, Bala C, Kostomiris, Demetrios H, Hsu, Jason, Zhu, Jiyun, Taylor, Zane W, Kocurek, Klaudia I, Tat, Vivian, Katzfuss, Ardala, Li, Linfeng, Giardini, Miriam A, Skinner, Danielle, Hirata, Ken, Yoon, Michael C, Beck, Sungjun, Carlin, Aaron F, Clark, Alex E, Beretta, Laura, Maneval, Daniel, Hook, Vivian, Frueh, Felix, Hurst, Brett L, Wang, Hong, Raushel, Frank M, O’Donoghue, Anthony J, de Siqueira-Neto, Jair Lage, Meek, Thomas D, McKerrow, James H
Published in ACS chemical biology (16.04.2021)
Published in ACS chemical biology (16.04.2021)
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