A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
Tzelepis, Konstantinos, Koike-Yusa, Hiroko, De Braekeleer, Etienne, Li, Yilong, Metzakopian, Emmanouil, Dovey, Oliver M., Mupo, Annalisa, Grinkevich, Vera, Li, Meng, Mazan, Milena, Gozdecka, Malgorzata, Ohnishi, Shuhei, Cooper, Jonathan, Patel, Miten, McKerrell, Thomas, Chen, Bin, Domingues, Ana Filipa, Gallipoli, Paolo, Teichmann, Sarah, Ponstingl, Hannes, McDermott, Ultan, Saez-Rodriguez, Julio, Huntly, Brian J.P., Iorio, Francesco, Pina, Cristina, Vassiliou, George S., Yusa, Kosuke
Published in Cell reports (Cambridge) (18.10.2016)
Published in Cell reports (Cambridge) (18.10.2016)
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Journal Article
The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis
Scholl, Claudia, Bansal, Dimple, Döhner, Konstanze, Eiwen, Karina, Huntly, Brian J P, Lee, Benjamin H, Rücker, Frank G, Schlenk, Richard F, Bullinger, Lars, Döhner, Hartmut, Gilliland, D Gary, Fröhling, Stefan
Published in The Journal of clinical investigation (01.04.2007)
Published in The Journal of clinical investigation (01.04.2007)
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Journal Article
Targeting Epigenetic Readers in Cancer
Dawson, Mark A, Kouzarides, Tony, Huntly, Brian J.P
Published in The New England journal of medicine (16.08.2012)
Published in The New England journal of medicine (16.08.2012)
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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
Dawson, Mark A., Prinjha, Rab K., Dittmann, Antje, Giotopoulos, George, Bantscheff, Marcus, Chan, Wai-In, Robson, Samuel C., Chung, Chun-wa, Hopf, Carsten, Savitski, Mikhail M., Huthmacher, Carola, Gudgin, Emma, Lugo, Dave, Beinke, Soren, Chapman, Trevor D., Roberts, Emma J., Soden, Peter E., Auger, Kurt R., Mirguet, Olivier, Doehner, Konstanze, Delwel, Ruud, Burnett, Alan K., Jeffrey, Phillip, Drewes, Gerard, Lee, Kevin, Huntly, Brian J. P., Kouzarides, Tony
Published in Nature (London) (27.10.2011)
Published in Nature (London) (27.10.2011)
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Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML
Basheer, Faisal, Giotopoulos, George, Meduri, Eshwar, Yun, Haiyang, Mazan, Milena, Sasca, Daniel, Gallipoli, Paolo, Marando, Ludovica, Gozdecka, Malgorzata, Asby, Ryan, Sheppard, Olivia, Dudek, Monika, Bullinger, Lars, Döhner, Hartmut, Dillon, Richard, Freeman, Sylvie, Ottmann, Oliver, Burnett, Alan, Russell, Nigel, Papaemmanuil, Elli, Hills, Robert, Campbell, Peter, Vassiliou, George S, Huntly, Brian J P
Published in The Journal of experimental medicine (01.04.2019)
Published in The Journal of experimental medicine (01.04.2019)
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Journal Article
KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements
Au, Yan Zi, Gu, Muxin, De Braekeleer, Etienne, Gozdecka, Malgorzata, Aspris, Demetrios, Tarumoto, Yusuke, Cooper, Jonathan, Yu, Jason, Ong, Swee Hoe, Chen, Xi, Tzelepis, Konstantinos, Huntly, Brian J. P., Vassiliou, George, Yusa, Kosuke
Published in Leukemia (01.04.2021)
Published in Leukemia (01.04.2021)
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Functional interdependence of BRD4 and DOT1L in MLL leukemia
Gilan, Omer, Lam, Enid Y N, Becher, Isabelle, Lugo, Dave, Cannizzaro, Ester, Joberty, Gerard, Ward, Aoife, Wiese, Meike, Fong, Chun Yew, Ftouni, Sarah, Tyler, Dean, Stanley, Kym, MacPherson, Laura, Weng, Chen-Fang, Chan, Yih-Chih, Ghisi, Margherita, Smil, David, Carpenter, Christopher, Brown, Peter, Garton, Neil, Blewitt, Marnie E, Bannister, Andrew J, Kouzarides, Tony, Huntly, Brian J P, Johnstone, Ricky W, Drewes, Gerard, Dawson, Sarah-Jane, Arrowsmith, Cheryl H, Grandi, Paola, Prinjha, Rab K, Dawson, Mark A
Published in Nature structural & molecular biology (01.07.2016)
Published in Nature structural & molecular biology (01.07.2016)
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A guide to epigenetics in leukaemia stem cells
Agrawal‐Singh, Shuchi, Bagri, Jaana, Sakakini, Nathalie, Huntly, Brian J. P.
Published in Molecular oncology (01.12.2023)
Published in Molecular oncology (01.12.2023)
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Journal Article
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
Horton, Sarah J., Giotopoulos, George, Yun, Haiyang, Vohra, Shabana, Sheppard, Olivia, Bashford-Rogers, Rachael, Rashid, Mamunur, Clipson, Alexandra, Chan, Wai-In, Sasca, Daniel, Yiangou, Loukia, Osaki, Hikari, Basheer, Faisal, Gallipoli, Paolo, Burrows, Natalie, Erdem, Ayşegül, Sybirna, Anastasiya, Foerster, Sarah, Zhao, Wanfeng, Sustic, Tonci, Petrunkina Harrison, Anna, Laurenti, Elisa, Okosun, Jessica, Hodson, Daniel, Wright, Penny, Smith, Ken G., Maxwell, Patrick, Fitzgibbon, Jude, Du, Ming Q., Adams, David J., Huntly, Brian J. P.
Published in Nature cell biology (01.09.2017)
Published in Nature cell biology (01.09.2017)
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Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1
Göttgens, Berthold, Bycroft, Mark, Bonadies, Nicolas, Santiveri, Clara M, Kvinlaug, Brynn T, Allen, Mark D, Freund, Stefan M V, Vezzoli, Alessandro, Huntly, Brian J P
Published in Nature structural & molecular biology (01.05.2010)
Published in Nature structural & molecular biology (01.05.2010)
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Journal Article
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
Booth, Christopher A.G., Barkas, Nikolaos, Neo, Wen Hao, Boukarabila, Hanane, Soilleux, Elizabeth J., Giotopoulos, George, Farnoud, Noushin, Giustacchini, Alice, Ashley, Neil, Carrelha, Joana, Jamieson, Lauren, Atkinson, Deborah, Bouriez-Jones, Tiphaine, Prinjha, Rab K., Milne, Thomas A., Teachey, David T., Papaemmanuil, Elli, Huntly, Brian J.P., Jacobsen, Sten Eirik W., Mead, Adam J.
Published in Cancer cell (12.02.2018)
Published in Cancer cell (12.02.2018)
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FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitors in a Murine Model of Chronic Myelomonocytic Leukemia
Lee, Benjamin H., Tothova, Zuzana, Levine, Ross L., Anderson, Kristina, Buza-Vidas, Natalija, Cullen, Dana E., McDowell, Elizabeth P., Adelsperger, Jennifer, Fröhling, Stefan, Huntly, Brian J.P., Beran, Miloslav, Jacobsen, Sten Eirik, Gilliland, D. Gary
Published in Cancer cell (01.10.2007)
Published in Cancer cell (01.10.2007)
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Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias
KVINLAUG, Brynn T, CHAN, Wai-In, DE SILVA, Inusha, VALK, Peter J. M, DELWEL, Ruud, ARMSTRONG, Scott A, DÖHNER, Hartmut, GILLILAND, D. Gary, HUNTLY, Brian J. P, BULLINGER, Lars, RAMASWAMI, Mukundhan, SEARS, Christopher, FOSTER, Donna, LAZIC, Stanley E, OKABE, Rachel, BENNER, Axel, LEE, Benjamin H
Published in Cancer research (Chicago, Ill.) (15.06.2011)
Published in Cancer research (Chicago, Ill.) (15.06.2011)
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Disordered signaling in myeloproliferative neoplasms
Anand, Shubha, Huntly, Brian J P
Published in Hematology/oncology clinics of North America (01.10.2012)
Published in Hematology/oncology clinics of North America (01.10.2012)
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