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Huntingtin Lowering Strategies
Marxreiter, Franz, Stemick, Judith, Kohl, Zacharias
Published in International journal of molecular sciences (20.03.2020)
Published in International journal of molecular sciences (20.03.2020)
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Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity
Lemarié, Fanny L., Caron, Nicholas S., Sanders, Shaun S., Schmidt, Mandi E., Nguyen, Yen T.N., Ko, Seunghyun, Xu, Xiaohong, Pouladi, Mahmoud A., Martin, Dale D.O., Hayden, Michael R.
Published in Neurobiology of disease (01.10.2021)
Published in Neurobiology of disease (01.10.2021)
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In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects
Faideau, Mathilde, Kim, Jinho, Cormier, Kerry, Gilmore, Richard, Welch, Mackenzie, Auregan, Gwennaelle, Dufour, Noelle, Guillermier, Martine, Brouillet, Emmanuel, Hantraye, Philippe, Déglon, Nicole, Ferrante, Robert J., Bonvento, Gilles
Published in Human molecular genetics (01.08.2010)
Published in Human molecular genetics (01.08.2010)
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Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
Dewan, Ramita, Keagle, Pamela, Bacikova, Dagmar, Soltis, Anthony R., Kost, Jason, Colombrita, Claudia, Lewis, Elizabeth A., Pensato, Viviana, Castellotti, Barbara, McLaughlin, Russell L., Comi, Giacomo P., Ceroni, Mauro, Gagliardi, Stella, van Blitterswijk, Marka, Corrado, Lucia, Sorarù, Gianni, Williams, Kelly L., Morrison, Karen E., Veldink, Jan H., Brown, Robert H., Ambrose, John C., Brittain, H., Elgar, Greg, Halai, Dina, Holman, James E., Jackson, Rob, Leong, Ivonne U.S., Maleady-Crowe, Fiona, Mason, Joanne, Riesgo-Ferreiro, Pablo, Rogers, Tim, Watters, Sarah A., Arepalli, Sampath, Chiò, Adriano, Dunckley, Travis L., Faghri, Faraz, Feldman, Eva, Floeter, Mary Kay, Gerhard, Glenn, Jansson, Lilja, Kirby, Janine, Mora, Gabriele, Nalls, Mike A., Pulst, Stefan M., Ravits, John M., Renton, Alan E., Robberecht, Wim, Robey, Ian, Dols-Icardo, Oriol, Illán-Gala, Ignacio, Lleó, Alberto, Khoshnood, Behzad, Sorbi, Sandro, Pastor, Pau, Bigio, Eileen H., Black, Sandra E., Brunetti, Maura, Canosa, Antonio, Gan-Or, Ziv, Goate, Alison, Hupalo, Daniel, Infante, Jon, Kaufmann, Horacio, Kim, Ronald C., Krüger, Rejko, Logroscino, Giancarlo, Love, Seth, Mao, Qinwen, Masliah, Eliezer, Pletnikova, Olga, Reynolds, Regina H., Scherzer, Clemens R., Serrano, Geidy E., Xiromerisiou, Georgia, Phatnani, Hemali, Kwan, Justin, Broach, James R., Arcila-Londono, Ximena, Malaspina, Andrea, Thompson, Leslie M., Dardiotis, Efthimios, Chandran, Siddharthan, Butovsky, Oleg, Dubnau, Joshua, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Altschuler, Steven, Hu, Michele T.M., Leigh, P. Nigel, Massey, Luke A., Pavese, Nicola, Vaughan, Jenny, Rowe, James B., Ghidoni, Roberta, Ryten, Mina, Tanaka, Toshiko, Ferrucci, Luigi, Vonsattel, Jean Paul, Landers, John E.
Published in Neuron (Cambridge, Mass.) (03.02.2021)
Published in Neuron (Cambridge, Mass.) (03.02.2021)
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Mutations causing Lopes-Maciel-Rodan syndrome are huntingtin hypomorphs
Jung, Roy, Lee, Yejin, Barker, Douglas, Correia, Kevin, Shin, Baehyun, Loupe, Jacob, Collins, Ryan L, Lucente, Diane, Ruliera, Jayla, Gillis, Tammy, Mysore, Jayalakshmi S, Rodan, Lance, Picker, Jonathan, Lee, Jong-Min, Howland, David, Lee, Ramee, Kwak, Seung, MacDonald, Marcy E, Gusella, James F, Seong, Ihn Sik
Published in Human molecular genetics (26.04.2021)
Published in Human molecular genetics (26.04.2021)
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Huntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin
Tan, Z, Dai, W, van Erp, T G M, Overman, J, Demuro, A, Digman, M A, Hatami, A, Albay, R, Sontag, E M, Potkin, K T, Ling, S, Macciardi, F, Bunney, W E, Long, J D, Paulsen, J S, Ringman, J M, Parker, I, Glabe, C, Thompson, L M, Chiu, W, Potkin, S G
Published in Molecular psychiatry (01.11.2015)
Published in Molecular psychiatry (01.11.2015)
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An exploration of the genetics of the mutant Huntingtin (mHtt) gene in a cohort of patients with chorea from different ethnic groups in sub‐Saharan Africa
Muthinja, Mendi J, Guelngar, Carlos Othon, Fall, Maouly, Jama, Fatumah, Shuja, Huda Aldeen, Nambafu, Jamila, Massi, Daniel Gams, Ojo, Oluwadamilola O., Okubadejo, Njideka U., Taiwo, Funmilola Tolulope, Diop, Alassane Mamadou, Chacus, Coudjou J. D. G., Cissé, Fodé Abass, Cissé, Amara, Hooker, Juzar, Sokhi, Dilraj, Houlden, Henry, Rizig, Mie
Published in Annals of human genetics (01.07.2025)
Published in Annals of human genetics (01.07.2025)
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Wild-type huntingtin regulates human macrophage function
O’Regan, Grace C., Farag, Sahar H., Ostroff, Gary R., Tabrizi, Sarah J., Andre, Ralph
Published in Scientific reports (14.10.2020)
Published in Scientific reports (14.10.2020)
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Salivary Huntingtin protein is uniquely associated with clinical features of Huntington’s disease
Parkin, Georgia M., Corey-Bloom, Jody, Snell, Chase, Smith, Haileigh, Laurenza, Angela, Daldin, Manuel, Bresciani, Alberto, Thomas, Elizabeth A.
Published in Scientific reports (19.01.2023)
Published in Scientific reports (19.01.2023)
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Evidence of mutant huntingtin and tau-related pathology within neuronal grafts in Huntington’s disease cases
Salem, Shireen, Kilgore, Mitchell D., Anwer, Mehwish, Maxan, Alexander, Child, Dan, Bird, Thomas D., Keene, C. Dirk, Cicchetti, Francesca, Latimer, Caitlin
Published in Neurobiology of disease (01.08.2024)
Published in Neurobiology of disease (01.08.2024)
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Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights
Pérez‐Oliveira, Sergio, Castilla‐Silgado, Juan, Painous, Cèlia, Aldecoa, Iban, Menéndez‐González, Manuel, Blázquez‐Estrada, Marta, Corte, Daniela, Tomás‐Zapico, Cristina, Compta, Yaroslau, Muñoz, Esteban, Lladó, Albert, Balasa, Mircea, Aragonès, Gemma, García‐González, Pablo, Rosende‐Roca, Maitée, Boada, Mercè, Ruíz, Agustín, Pastor, Pau, De la Casa‐Fages, Beatriz, Rabano, Alberto, Sánchez‐Valle, Raquel, Molina‐Porcel, Laura, Álvarez, Victoria
Published in Brain pathology (Zurich, Switzerland) (01.07.2024)
Published in Brain pathology (Zurich, Switzerland) (01.07.2024)
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A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (HTT)
De Luca, Alessandro, Morella, Annunziata, Consoli, Federica, Fanelli, Sergio, Thibert, Julie R., Statt, Sarah, Latham, Gary J., Squitieri, Ferdinando
Published in International journal of molecular sciences (08.02.2021)
Published in International journal of molecular sciences (08.02.2021)
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Increased apoptosis, huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects
Ciammola, A, Sassone, J, Alberti, L, Meola, G, Mancinelli, E, Russo, M A, Squitieri, F, Silani, V
Published in Cell death and differentiation (01.12.2006)
Published in Cell death and differentiation (01.12.2006)
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Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes
Juenemann, Katrin, Schipper-Krom, Sabine, Wiemhoefer, Anne, Kloss, Alexander, Sanz Sanz, Alicia, Reits, Eric A.J.
Published in The Journal of biological chemistry (20.09.2013)
Published in The Journal of biological chemistry (20.09.2013)
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Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis
Andre, Ralph, Carty, Lucy, Tabrizi, Sarah J
Published in Current opinion in pharmacology (01.02.2016)
Published in Current opinion in pharmacology (01.02.2016)
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Making (anti-) sense out of huntingtin levels in Huntington disease
Evers, Melvin M, Schut, Menno H, Pepers, Barry A, Atalar, Melek, van Belzen, Martine J, Faull, Richard LM, Roos, Raymund AC, van Roon-Mom, Willeke MC
Published in Molecular neurodegeneration (28.04.2015)
Published in Molecular neurodegeneration (28.04.2015)
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Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin
Pouladi, Mahmoud A., Graham, Rona K., Karasinska, Joanna M., Xie, Yuanyun, Santos, Rachelle Dar, Petersén, Åsa, Hayden, Michael R.
Published in Brain (London, England : 1878) (01.04.2009)
Published in Brain (London, England : 1878) (01.04.2009)
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