Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition
Reich, Siegfried H, Sprengeler, Paul A, Chiang, Gary G, Appleman, James R, Chen, Joan, Clarine, Jeff, Eam, Boreth, Ernst, Justin T, Han, Qing, Goel, Vikas K, Han, Edward Z. R, Huang, Vera, Hung, Ivy N. J, Jemison, Adrianna, Jessen, Katti A, Molter, Jolene, Murphy, Douglas, Neal, Melissa, Parker, Gregory S, Shaghafi, Michael, Sperry, Samuel, Staunton, Jocelyn, Stumpf, Craig R, Thompson, Peggy A, Tran, Chinh, Webber, Stephen E, Wegerski, Christopher J, Zheng, Hong, Webster, Kevin R
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
Get full text
Journal Article
Abstract 1302: Targeting hormone receptor-dependent cancers with potent, selective and orally-available small molecule inhibitors of eIF4E
Chiang, Gary G., Parker, Gregory S., Hung, Ivy N., Goel, Vikas K., Staunton, Jocelyn, Barrera, Maria, Sung, Eric, Parra, Ana, Stumpf, Craig R., Chen, Joan, Thompson, Peggy A., Nevarez, Andreas, Wegerski, Christopher J., Parker, Cody, Clarine, Jeff, Sperry, Samuel, Xiang, Alan, Nilewski, Christian, Packard, Garrick K., Urkalan, Kaveri, Mukaiyama, Takasuke, Michels, Theo, Ernst, Justin T., Sprengeler, Paul A., Reich, Siegfried H., Webster, Kevin R.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract 596: eFT508, a potent and highly selective inhibitor of MNK1/2 regulates immune checkpoint and cytokine expression promoting anti-tumor immunity
Webster, Kevin R., Goel, Vikas K., Staunton, Jocelyn, Stumpf, Craig R., Sharma, Rajesh, Hung, Ivy N., Parker, Gregory S., Molter, Jolene, Chiang, Gary G., Wegerski, Christopher J., Sperry, Samuel, Huang, Vera, Chen, Joan, Thompson, Peggy A., Tran, Chinh, Ernst, Justin T., Sprengeler, Paul A., Reich, Siegfried H.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-Tumor Activity in B-Cell Malignancies
Thompson, Peggy A, Eam, Boreth, Young, Nathan P, Fish, Sarah, Chen, Joan, Barrera, Maria, Howard, Haleigh, Parra, Ana, Molter, Jolene, Staunton, Jocelyn, Hung, Ivy NJ, Parker, Greg S, Chiang, Gary G, Wegerski, Chris J, Nevarez, Andres, Clarine, Jeff, Sperry, Sam, Xiang, Alan, Tran, Chinh, Nilewski, Christian, Packard, Garrick K, Michels, Theodore, Sprengeler, Paul A, Ernst, Justin T, Reich, Siegfried H, Webster, Kevin R
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
Get full text
Journal Article
Abstract PR11: eFT508: An oral, potent and highly selective inhibitor of MNK1 and MNK2, promotes anti-tumor immunity as a monotherapy and in combination with immune checkpoint blockade
Webster, Kevin R., Goel, Vikas K., Staunton, Jocelyn, Hung, Ivy NJ, Parker, Gregory S., Stumpf, Craig R., Molter, Jolene, Chiang, Gary G., Wegerski, Christopher J., Sperry, Samuel, Chen, Joan, Huang, Vera, Thompson, Peggy A., Tran, Chinh, Ernst, Justin T., Webber, Stephen E., Sprengeler, Paul A., Reich, Siegfried H.
Published in Cancer research (Chicago, Ill.) (15.03.2017)
Published in Cancer research (Chicago, Ill.) (15.03.2017)
Get full text
Journal Article
eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL)
Webster, Kevin R., Goel, Vikas K, Hung, Ivy NJ, Parker, Gregory S, Staunton, Jocelyn, Neal, Melissa, Molter, Jolene, Chiang, Gary G, Jessen, Katti A., Wegerski, Christopher J, Sperry, Samuel, Huang, Vera, Chen, Joan, Thompson, Peggy A, Appleman, James R, Webber, Stephen E, Sprengeler, Paul A, Reich, Siegfried H
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
Get full text
Journal Article