The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin
Burzynski, Laura C., Humphry, Melanie, Pyrillou, Katerina, Wiggins, Kimberley A., Chan, Julie N.E., Figg, Nichola, Kitt, Lauren L., Summers, Charlotte, Tatham, Kate C., Martin, Paul B., Bennett, Martin R., Clarke, Murray C.H.
Published in Immunity (Cambridge, Mass.) (16.04.2019)
Published in Immunity (Cambridge, Mass.) (16.04.2019)
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Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation
Zheng, Yue, Humphry, Melanie, Maguire, Janet J., Bennett, Martin R., Clarke, Murray C.H.
Published in Immunity (Cambridge, Mass.) (21.02.2013)
Published in Immunity (Cambridge, Mass.) (21.02.2013)
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IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype
Wiggins, Kimberley A., Parry, Aled J., Cassidy, Liam D., Humphry, Melanie, Webster, Steve J., Goodall, Jane C., Narita, Masashi, Clarke, Murray C. H.
Published in Aging cell (01.06.2019)
Published in Aging cell (01.06.2019)
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Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production
Burzynski, Laura C, Morales-Maldonado, Alejandra, Rodgers, Amanda, Kitt, Lauren A, Humphry, Melanie, Figg, Nichola, Bennett, Martin R, Clarke, Murray C H
Published in Cardiovascular research (16.10.2023)
Published in Cardiovascular research (16.10.2023)
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The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin‐1α release from human blood cells
Wiggins, Kimberley A., Pyrillou, Katerina, Humphry, Melanie, Butterworth, Adam S., Clarke, Murray CH
Published in Immunology (01.03.2023)
Published in Immunology (01.03.2023)
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Plastidic Bile Acid Transporter 5 Is Required for the Biosynthesis of Methionine-Derived Glucosinolates in Arabidopsis thaliana
Gigolashvili, Tamara, Yatusevich, Ruslan, Rollwitz, Inga, Humphry, Melanie, Gershenzon, Jonathan, Flügge, Ulf-Ingo
Published in The Plant cell (01.06.2009)
Published in The Plant cell (01.06.2009)
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191Interleukin-1 Alpha is Directly Activated During Haemostasis by Thrombin Cleavage
Burzynski, Laura, Humphry, Melanie, Bennett, Martin, Clarke, Murray
Published in Heart (British Cardiac Society) (01.06.2015)
Published in Heart (British Cardiac Society) (01.06.2015)
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191 Interleukin-1 Alpha is Directly Activated During Haemostasis by Thrombin Cleavage
Burzynski, Laura, Humphry, Melanie, Bennett, Martin, Clarke, Murray
Published in Heart (British Cardiac Society) (01.06.2015)
Published in Heart (British Cardiac Society) (01.06.2015)
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Cell surface IL‐1α trafficking is specifically inhibited by interferon‐γ, and associates with the membrane via IL‐1R2 and GPI anchors
Chan, Julie N.E., Humphry, Melanie, Kitt, Lauren, Krzyzanska, Dominika, Filbey, Kara J., Bennett, Martin R., Clarke, Murray C.H.
Published in European journal of immunology (01.11.2020)
Published in European journal of immunology (01.11.2020)
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Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION
Burzynski, Laura C, Humphry, Melanie, Bennett, Martin R, Clarke, Murray C H
Published in The Journal of biological chemistry (09.10.2015)
Published in The Journal of biological chemistry (09.10.2015)
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Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1
Pyrillou, Katerina, Humphry, Melanie, Kitt, Lauren A, Rodgers, Amanda, Nus, Meritxell, Bennett, Martin R, Smith, Kenneth Gc, Lyons, Paul A, Mallat, Ziad, Clarke, Murray Ch
Published in JCI insight (08.02.2024)
Published in JCI insight (08.02.2024)
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Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype
Gardner, Sarah E, Humphry, Melanie, Bennett, Martin R, Clarke, Murray C.H
Published in Arteriosclerosis, thrombosis, and vascular biology (01.09.2015)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.09.2015)
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Journal Article
Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1[alpha], Controlling Necrosis-Induced Sterile Inflammation
Zheng, Yue, Humphry, Melanie, Maguire, Janet J, Bennett, Martin R, Clarke, Murray CH
Published in Immunity (Cambridge, Mass.) (21.02.2013)
Published in Immunity (Cambridge, Mass.) (21.02.2013)
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