8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor
Humphries, Alexander C., Gancia, Emanuela, Gilligan, Myra T., Goodacre, Simon, Hallett, David, Merchant, Kevin J., Thomas, Steve R.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Journal Article
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia
Fish, L Rebecca, Gilligan, Myra T, Humphries, Alexander C, Ivarsson, Magnus, Ladduwahetty, Tammy, Merchant, Kevin J, O'Connor, Desmond, Patel, Smita, Philipps, Elisabeth, Vargas, Hugo M, Hutson, Peter H, MacLeod, Angus M
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
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Journal Article
Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines
Dias, Rebecca, Sheppard, Wayne F. A., Fradley, Rosa L., Garrett, Elizabeth M., Stanley, Joanna L., Tye, Spencer J., Goodacre, Simon, Lincoln, Rachael J., Cook, Susan M., Conley, Rachel, Hallett, David, Humphries, Alexander C., Thompson, Sally A., Wafford, Keith A., Street, Leslie J., Castro, J. Luis, Whiting, Paul J., Rosahl, Thomas W., Atack, John R., McKernan, Ruth M., Dawson, Gerard R., Reynolds, David S.
Published in The Journal of neuroscience (16.11.2005)
Published in The Journal of neuroscience (16.11.2005)
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Journal Article
8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor
Humphries, Alexander C, Gancia, Emanuela, Gilligan, Myra T, Goodacre, Simon, Hallett, David, Merchant, Kevin J, Thomas, Steve R
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Get full text
Journal Article
8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA sub(A) receptor
Humphries, Alexander C, Gancia, Emanuela, Gilligan, Myra T, Goodacre, Simon, Hallett, David, Merchant, Kevin J, Thomas, Steve R
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
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Journal Article
Evidence for a Significant Role of α3-Containing GABA A Receptors in Mediating the Anxiolytic Effects of Benzodiazepines
Dias, Rebecca, Sheppard, Wayne F. A., Fradley, Rosa L., Garrett, Elizabeth M., Stanley, Joanna L., Tye, Spencer J., Goodacre, Simon, Lincoln, Rachael J., Cook, Susan M., Conley, Rachel, Hallett, David, Humphries, Alexander C., Thompson, Sally A., Wafford, Keith A., Street, Leslie J., Castro, J. Luis, Whiting, Paul J., Rosahl, Thomas W., Atack, John R., McKernan, Ruth M., Dawson, Gerard R., Reynolds, David S.
Published in The Journal of neuroscience (16.11.2005)
Published in The Journal of neuroscience (16.11.2005)
Get full text
Journal Article
Evidence for a Significant Role of alpha 3-Containing GABA sub(A) Receptors in Mediating the Anxiolytic Effects of Benzodiazepines
Dias, Rebecca, Sheppard, Wayne FA, Fradley, Rosa L, Garrett, Elizabeth M, Stanley, Joanna L, Tye, Spencer J, Goodacre, Simon, Lincoln, Rachael J, Cook, Susan M, Conley, Rachel, Hallett, David, Humphries, Alexander C, Thompson, Sally A, Wafford, Keith A, Street, Leslie J, Castro, JLuis, Whiting, Paul J, Rosahl, Thomas W, Atack, John R, McKernan, Ruth M, Dawson, Gerard R, Reynolds, David S
Published in The Journal of neuroscience (01.11.2005)
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Published in The Journal of neuroscience (01.11.2005)
Journal Article
4-Fluorosulfonylpiperidines : Selective 5-HT2A ligands for the treatment of insomnia: G-protein-coupled receptors in drug discovery
FISH, L. Rebecca, GILLIGAN, Myra T, HUTSON, Peter H, MACLEOD, Angus M, HUMPHRIES, Alexander C, IVARSSON, Magnus, LADDUWAHETTY, Tammy, MERCHANT, Kevin J, O'CONNOR, Desmond, PATEL, Smita, PHILIPPS, Elisabeth, VARGAS, Hugo M
Published in Bioorganic & medicinal chemistry letters (2005)
Get full text
Published in Bioorganic & medicinal chemistry letters (2005)
Journal Article
4-Fluorosulfonylpiperidines: Selective 5-HT 2A ligands for the treatment of insomnia
Fish, L. Rebecca, Gilligan, Myra T., Humphries, Alexander C., Ivarsson, Magnus, Ladduwahetty, Tammy, Merchant, Kevin J., O’Connor, Desmond, Patel, Smita, Philipps, Elisabeth, Vargas, Hugo M., Hutson, Peter H., MacLeod, Angus M.
Published in Bioorganic & medicinal chemistry letters (2005)
Published in Bioorganic & medicinal chemistry letters (2005)
Get full text
Journal Article
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines
Dias, Rebecca, Sheppard, Wayne F A, Fradley, Rosa L, Garrett, Elizabeth M, Stanley, Joanna L, Tye, Spencer J, Goodacre, Simon, Lincoln, Rachael J, Cook, Susan M, Conley, Rachel, Hallett, David, Humphries, Alexander C, Thompson, Sally A, Wafford, Keith A, Street, Leslie J, Castro, J Luis, Whiting, Paul J, Rosahl, Thomas W, Atack, John R, McKernan, Ruth M, Dawson, Gerard R, Reynolds, David S
Published in The Journal of neuroscience (16.11.2005)
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Published in The Journal of neuroscience (16.11.2005)
Journal Article
Using a Temporary Silicon Connection in a Highly Stereoselective Synthesis of a New Class of Cyclic Allenylsilanes
Ramalho, Rui, Beignet, Julien, Humphries, Alexander C., Cox, Liam R.
Published in ChemInform (02.05.2006)
Published in ChemInform (02.05.2006)
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