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Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia
Hering, Bernhard J., Clarke, William R., Bridges, Nancy D., Eggerman, Thomas L., Alejandro, Rodolfo, Bellin, Melena D., Chaloner, Kathryn, Czarniecki, Christine W., Goldstein, Julia S., Hunsicker, Lawrence G., Kaufman, Dixon B., Korsgren, Olle, Larsen, Christian P., Luo, Xunrong, Markmann, James F., Naji, Ali, Oberholzer, Jose, Posselt, Andrew M., Rickels, Michael R., Ricordi, Camillo, Robien, Mark A., Senior, Peter A., Shapiro, A.M. James, Stock, Peter G., Turgeon, Nicole A.
Published in Diabetes care (01.07.2016)
Published in Diabetes care (01.07.2016)
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The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro
Pingitore, Attilio, Chambers, Edward S., Hill, Thomas, Maldonado, Inmaculada Ruz, Liu, Bo, Bewick, Gavin, Morrison, Douglas J., Preston, Tom, Wallis, Gareth A., Tedford, Catriona, Castañera González, Ramón, Huang, Guo C., Choudhary, Pratik, Frost, Gary, Persaud, Shanta J.
Published in Diabetes, obesity & metabolism (01.02.2017)
Published in Diabetes, obesity & metabolism (01.02.2017)
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Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
Yeh, Yu-Te, Sona, Chandan, Yan, Xin, Li, Yunxiao, Pathak, Adrija, McDermott, Mark I., Xie, Zhigang, Liu, Liangwen, Arunagiri, Anoop, Wang, Yuting, Cazenave-Gassiot, Amaury, Ghosh, Adhideb, von Meyenn, Ferdinand, Kumarasamy, Sivarajan, Najjar, Sonia M., Jia, Shiqi, Wenk, Markus R., Traynor-Kaplan, Alexis, Arvan, Peter, Barg, Sebastian, Bankaitis, Vytas A., Poy, Matthew N.
Published in Nature communications (17.07.2023)
Published in Nature communications (17.07.2023)
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Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes
Omar, Bilal A., Liehua, Liu, Yamada, Yuchiro, Seino, Yutaka, Marchetti, Piero, Ahrén, B.
Published in Diabetologia (01.09.2014)
Published in Diabetologia (01.09.2014)
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Metformin restores prohormone processing enzymes and normalizes aberrations in secretion of proinsulin and insulin in palmitate‐exposed human islets
Wen, Quan, Chowdhury, Azazul Islam, Aydin, Banu, Shekha, Mudhir, Stenlid, Rasmus, Forslund, Anders, Bergsten, Peter
Published in Diabetes, obesity & metabolism (01.12.2023)
Published in Diabetes, obesity & metabolism (01.12.2023)
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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets
El, Kimberley, Douros, Jonathan D., Willard, Francis S., Novikoff, Aaron, Sargsyan, Ashot, Perez-Tilve, Diego, Wainscott, David B., Yang, Bin, Chen, Alex, Wothe, Donald, Coupland, Callum, Tschöp, Mattias H., Finan, Brian, D’Alessio, David A., Sloop, Kyle W., Müller, Timo D., Campbell, Jonathan E.
Published in Nature metabolism (01.06.2023)
Published in Nature metabolism (01.06.2023)
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Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels
Lindqvist, A., Shcherbina, L., Prasad, R.B., Miskelly, M.G., Abels, M., Martínez-Lopéz, J.A., Fred, R.G., Nergård, B.J., Hedenbro, J., Groop, L., Hjerling-Leffler, J., Wierup, N.
Published in Molecular and cellular endocrinology (01.07.2020)
Published in Molecular and cellular endocrinology (01.07.2020)
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1846-P: Human α-Cell Heterogeneity and Trajectory Inference Analyses of Human Islets Reveal SMOC1 as a β-Cell Dedifferentiation Gene
KANG, RANDY, VARELA, MIGUEL A., OH, EUNJIN, LEE, JUNGEUN, KARAKOSE, ESRA, STEWART, ANDREW F., SCOTT, DONALD, THURMOND, DEBBIE C., GARCIA-OCANA, ADOLFO, LU, GEMING
Published in Diabetes (New York, N.Y.) (20.06.2025)
Published in Diabetes (New York, N.Y.) (20.06.2025)
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Cholecystokinin attenuates β-cell apoptosis in both mouse and human islets
Kim, HUNG TAE, DESOUZA, ARNALDO H., UMHOEFER, HEIDI, HAN, JEEYOUNG, ANZIA, LUCILLE, SACOTTE, STEVEN J., WILLIAMS, RASHAUN A., BLUMER, JOSEPH T., BARTOSIAK, JACOB T., FONTAINE, DANIELLE A., BAAN, MIEKE, KIBBE, CARLY R., DAVIS, DAWN BELT
Published in Translational research : the journal of laboratory and clinical medicine (01.05.2022)
Published in Translational research : the journal of laboratory and clinical medicine (01.05.2022)
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Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes
Brissova, Marcela, Shostak, Alena, Fligner, Corinne L., Revetta, Frank L., Washington, Mary K., Powers, Alvin C., Hull, Rebecca L.
Published in The journal of histochemistry and cytochemistry (01.08.2015)
Published in The journal of histochemistry and cytochemistry (01.08.2015)
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Amyloid inhibitors enhance survival of cultured human islets
Potter, Kathryn J., Scrocchi, Louise A., Warnock, Garth L., Ao, Ziliang, Younker, Marika A., Rosenberg, Lawrence, Lipsett, Mark, Verchere, C. Bruce, Fraser, Paul E.
Published in Biochimica et biophysica acta (01.06.2009)
Published in Biochimica et biophysica acta (01.06.2009)
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Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets
Rohatgi, Nidhi, Aly, Haytham, Marshall, Connie A., McDonald, William G., Kletzien, Rolf F., Colca, Jerry R., McDaniel, Michael L.
Published in PloS one (01.05.2013)
Published in PloS one (01.05.2013)
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Glucose Induces β-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets
Maedler, Kathrin, Spinas, Giatgen A., Lehmann, Roger, Sergeev, Pavel, Weber, Markus, Fontana, Adriano, Kaiser, Nurit, Donath, Marc Y.
Published in Diabetes (New York, N.Y.) (01.08.2001)
Published in Diabetes (New York, N.Y.) (01.08.2001)
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Differential sensitivity of human islets from obese versus lean donors to chronic high glucose or palmitate
Castex, Françoise, Leroy, Jeremy, Broca, Christophe, Mezghenna, Karima, Duranton, Flore, Lavallard, Vanessa, Lebreton, Fanny, Gross, René, Wojtusciszyn, Anne, Lajoix, Anne‐Dominique
Published in Journal of diabetes (01.07.2020)
Published in Journal of diabetes (01.07.2020)
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Gene expression analysis of human islets in a subject at onset of type 1 diabetes
Hopfgarten, Johan, Stenwall, Per-Anton, Wiberg, Anna, Anagandula, Mahesh, Ingvast, Sofie, Rosenling, Therese, Korsgren, Olle, Skog, Oskar
Published in Acta diabetologica (01.04.2014)
Published in Acta diabetologica (01.04.2014)
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