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A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein
DeVincenzo, John, Tait, Dereck, Efthimiou, John, Mori, Julie, Kim, Young-In, Thomas, Elaine, Wilson, Lynn, Harland, Rachel, Mathews, Neil, Cockerill, Stuart, Powell, Kenneth, Littler, Edward
Published in Antimicrobial agents and chemotherapy (27.01.2020)
Published in Antimicrobial agents and chemotherapy (27.01.2020)
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Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification
Sobel Leonard, Ashley, McClain, Micah T., Smith, Gavin J. D., Wentworth, David E., Halpin, Rebecca A., Lin, Xudong, Ransier, Amy, Stockwell, Timothy B., Das, Suman R., Gilbert, Anthony S., Lambkin-Williams, Robert, Ginsburg, Geoffrey S., Woods, Christopher W., Koelle, Katia
Published in Journal of virology (15.12.2016)
Published in Journal of virology (15.12.2016)
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Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection
Talaat, Kawsar R., Alaimo, Cristina, Martin, Patricia, Bourgeois, A. Louis, Dreyer, Anita M., Kaminski, Robert W., Porter, Chad K., Chakraborty, Subhra, Clarkson, Kristen A., Brubaker, Jessica, Elwood, Daniel, Frölich, Rahel, DeNearing, Barbara, Weerts, Hailey, Feijoo, Brittany L., Halpern, Jane, Sack, David, Riddle, Mark S., Fonck, Veronica Gambillara
Published in EBioMedicine (01.04.2021)
Published in EBioMedicine (01.04.2021)
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The Role of the Gut Microbiome in Resisting Norovirus Infection as Revealed by a Human Challenge Study
Patin, N. V., Peña-Gonzalez, A., Hatt, J. K., Moe, C., Kirby, A., Konstantinidis, K. T.
Published in mBio (17.11.2020)
Published in mBio (17.11.2020)
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Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study
Yogaratnam, Jeysen, Rito, Jennifer, Kakuda, Thomas N., Fennema, Hein, Gupta, Kusum, Jekle, C. Andreas, Mitchell, Toni, Boyce, Malcolm, Sahgal, Omair, Balaratnam, Ganesh, Chanda, Sushmita, Van Remoortere, Pieter, Symons, Julian A., Fry, John
Published in The Journal of infectious diseases (07.01.2019)
Published in The Journal of infectious diseases (07.01.2019)
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923. EDP-938, A Respiratory Syncytial Virus (RSV) antiviral, demonstrates a high barrier to resistance in a human challenge study
Levene, Rachel E, DeVincenzo, John, Conery, Annie, Ahmad, Alaa, Goodwin, Bryan, Or, Yat Sun, Rhodin, Michael
Published in Open forum infectious diseases (27.11.2023)
Published in Open forum infectious diseases (27.11.2023)
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An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution
Waddington, Claire S., Darton, Thomas C., Jones, Claire, Haworth, Kathryn, Peters, Anna, John, Tessa, Thompson, Ben A. V., Kerridge, Simon A., Kingsley, Robert A., Zhou, Liqing, Holt, Kathryn E., Yu, Ly-Mee, Lockhart, Stephen, Farrar, Jeremy J., Sztein, Marcelo B., Dougan, Gordon, Angus, Brian, Levine, Myron M., Pollard, Andrew J.
Published in Clinical infectious diseases (01.05.2014)
Published in Clinical infectious diseases (01.05.2014)
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Using the Influenza Patient-reported Outcome (FLU-PRO) diary to evaluate symptoms of influenza viral infection in a healthy human challenge model
Han, Alison, Poon, Jiat-Ling, Powers, John H., Leidy, Nancy K., Yu, Ren, Memoli, Matthew J.
Published in BMC infectious diseases (28.07.2018)
Published in BMC infectious diseases (28.07.2018)
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Production and Clinical Evaluation of Norwalk GI.1 Virus Lot 001-09NV in Norovirus Vaccine Development
Mateo, Roberto, Lindesmith, Lisa C, Garg, Shaily J, Gottlieb, Keith, Lin, Karen, Said, Sara, Leon, Juan S, Sims, Amy C, Weber, David J, Baric, Ralph S, Tucker, Sean N, Taylor, David N
Published in The Journal of infectious diseases (02.03.2020)
Published in The Journal of infectious diseases (02.03.2020)
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United Kingdom Begins First COVID-19 Human Challenge Study
Published in IRB advisor
(01.04.2021)
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Cocrystal Pharma Reports Phase 1 Results With Oral, Broad-Acting Antiviral Drug CDI-988 For Prophylaxis And Treatment Of Norovirus, Coronaviruses And Other Viral Infections; Data Show Favorable Safety And Tolerability With Dosing Up To 800 mg For 10 Days; Plans To Initiate Human Challenge Study In 2025 In Norovirus-infected Subjects
Published in Benzinga Newswires
(08.01.2025)
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Exploring Ethical Concerns About Human Challenge Studies: A Qualitative Study of Controlled Human Malaria Infection Study Participants' Motivations and Attitudes
Kraft, Stephanie A., Duenas, Devan M., Kublin, James G., Shipman, Kelly J., Murphy, Sean C., Shah, Seema K.
Published in Journal of empirical research on human research ethics (01.02.2019)
Published in Journal of empirical research on human research ethics (01.02.2019)
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ID Biomedical reports positive results from human challenge study of FluINsure(TM) vaccine
Published in PR Newswire
(18.09.2003)
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ID Biomedical reports positive results from human challenge study of FluINsure(TM) vaccine
Published in Canada NewsWire
(18.09.2003)
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