An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers
Villa, Genaro R., Hulce, Jonathan J., Zanca, Ciro, Bi, Junfeng, Ikegami, Shiro, Cahill, Gabrielle L., Gu, Yuchao, Lum, Kenneth M., Masui, Kenta, Yang, Huijun, Rong, Xin, Hong, Cynthia, Turner, Kristen M., Liu, Feng, Hon, Gary C., Jenkins, David, Martini, Michael, Armando, Aaron M., Quehenberger, Oswald, Cloughesy, Timothy F., Furnari, Frank B., Cavenee, Webster K., Tontonoz, Peter, Gahman, Timothy C., Shiau, Andrew K., Cravatt, Benjamin F., Mischel, Paul S.
Published in Cancer cell (14.11.2016)
Published in Cancer cell (14.11.2016)
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Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells
Hulce, Jonathan J, Cognetta, Armand B, Niphakis, Micah J, Tully, Sarah E, Cravatt, Benjamin F
Published in Nature methods (01.03.2013)
Published in Nature methods (01.03.2013)
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A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors
Lanning, Bryan R, Whitby, Landon R, Dix, Melissa M, Douhan, John, Gilbert, Adam M, Hett, Erik C, Johnson, Theodore O, Joslyn, Chris, Kath, John C, Niessen, Sherry, Roberts, Lee R, Schnute, Mark E, Wang, Chu, Hulce, Jonathan J, Wei, Baoxian, Whiteley, Laurence O, Hayward, Matthew M, Cravatt, Benjamin F
Published in Nature chemical biology (01.09.2014)
Published in Nature chemical biology (01.09.2014)
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Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
Ogasawara, Daisuke, Ichu, Taka-Aki, Vartabedian, Vincent F., Benthuysen, Jacqueline, Jing, Hui, Reed, Alex, Ulanovskaya, Olesya A., Hulce, Jonathan J., Roberts, Amanda, Brown, Steven, Rosen, Hugh, Teijaro, John R., Cravatt, Benjamin F.
Published in Nature chemical biology (01.12.2018)
Published in Nature chemical biology (01.12.2018)
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Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
Chen, Wentao, Dong, Jiajia, Plate, Lars, Mortenson, David E, Brighty, Gabriel J, Li, Suhua, Liu, Yu, Galmozzi, Andrea, Lee, Peter S, Hulce, Jonathan J, Cravatt, Benjamin F, Saez, Enrique, Powers, Evan T, Wilson, Ian A, Sharpless, K. Barry, Kelly, Jeffery W
Published in Journal of the American Chemical Society (15.06.2016)
Published in Journal of the American Chemical Society (15.06.2016)
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Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase alpha/beta-Hydrolase Domain-Containing 12 (ABHD12)
Ogasawara, Daisuke, Ichu, Taka-Aki, Jing, Hui, Hulce, Jonathan J., Reed, Alex, Ulanovskaya, Olesya A., Cravatt, Benjamin F.
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs
Parsons, William H, Kolar, Matthew J, Kamat, Siddhesh S, III, Armand B Cognetta, Hulce, Jonathan J, Saez, Enrique, Kahn, Barbara B, Saghatelian, Alan, Cravatt, Benjamin F
Published in Nature chemical biology (01.05.2016)
Published in Nature chemical biology (01.05.2016)
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The cortistatin gene PSS2 rather than the somatostatin gene PSS1 is strongly expressed in developing avian autonomic neurons
Nishi, Rae, Stubbusch, Jutta, Hulce, Jonathan J., Hruska, Martin, Pappas, Anthony, Bravo, Maria-Christina, Huber, Leslie P., Bakondi, Benjamin, Soltys, John, Rohrer, Hermann
Published in Journal of comparative neurology (1911) (15.03.2010)
Published in Journal of comparative neurology (1911) (15.03.2010)
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Discovery and Optimization of Selective and In Vivo-Active Inhibitors of the Lyso-phosphatidylserine Lipase α/β-Hydrolase Domain-containing 12 (ABHD12)
Ogasawara, Daisuke, Ichu, Taka-Aki, Jing, Hui, Hulce, Jonathan J., Reed, Alex, Ulanovskaya, Olesya A., Cravatt, Benjamin F.
Published in Journal of medicinal chemistry (05.02.2019)
Published in Journal of medicinal chemistry (05.02.2019)
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Prostate Stem Cell Antigen Is an Endogenous lynx1-Like Prototoxin That Antagonizes α7-Containing Nicotinic Receptors and Prevents Programmed Cell Death of Parasympathetic Neurons
Hruska, Martin, Keefe, Julie, Wert, David, Tekinay, Ayse Begum, Hulce, Jonathan J., Ibañez-Tallon, Ines, Nishi, Rae
Published in The Journal of neuroscience (25.11.2009)
Published in The Journal of neuroscience (25.11.2009)
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Journal Article
A roadmap to evaluate the proteome-wide selectivity of covalent kinase inhibitors
Lanning, Bryan R., Whitby, Landon R., Dix, Melissa M., Douhan, John, Gilbert, Adam M., Hett, Erik C., Johnson, Theodore O., Joslyn, Chris, Kath, John C., Niessen, Sherry, Roberts, Lee R., Schnute, Mark E., Wang, Chu, Hulce, Jonathan J., Wei, Baoxian, Whiteley, Laurence O., Hayward, Matthew M., Cravatt, Benjamin F.
Published in Nature chemical biology (13.07.2014)
Published in Nature chemical biology (13.07.2014)
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Journal Article
Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12)
Ogasawara, Daisuke, Ichu, Taka-Aki, Jing, Hui, Hulce, Jonathan J, Reed, Alex, Ulanovskaya, Olesya A, Cravatt, Benjamin F
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Journal Article
Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons
Hruska, Martin, Keefe, Julie, Wert, David, Tekinay, Ayse Begum, Hulce, Jonathan J, Ibañez-Tallon, Ines, Nishi, Rae
Published in The Journal of neuroscience (25.11.2009)
Published in The Journal of neuroscience (25.11.2009)
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Journal Article
Prostate Stem Cell Antigen Is an Endogenous lynx1-Like Prototoxin That Antagonizes {alpha}7-Containing Nicotinic Receptors and Prevents Programmed Cell Death of Parasympathetic Neurons
Hruska, Martin, Keefe, Julie, Wert, David, Tekinay, Ayse Begum, Hulce, Jonathan J, Ibanez-Tallon, Ines, Nishi, Rae
Published in The Journal of neuroscience (25.11.2009)
Published in The Journal of neuroscience (25.11.2009)
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