Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose
Hoffmann, Anna-Carin, Minakaki, Georgia, Menges, Stefanie, Salvi, Rachele, Savitskiy, Sergey, Kazman, Aida, Vicente Miranda, Hugo, Mielenz, Dirk, Klucken, Jochen, Winkler, Jürgen, Xiang, Wei
Published in Scientific reports (24.01.2019)
Published in Scientific reports (24.01.2019)
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Journal Article
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease
Vicente Miranda, Hugo, Cássio, Rafaela, Correia-Guedes, Leonor, Gomes, Marcos António, Chegão, Ana, Miranda, Elisa, Soares, Tiago, Coelho, Miguel, Rosa, Mário Miguel, Ferreira, Joaquim J, Outeiro, Tiago Fleming
Published in Scientific reports (20.10.2017)
Published in Scientific reports (20.10.2017)
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Journal Article
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation
Diógenes, Maria José, Dias, Raquel B, Rombo, Diogo M, Vicente Miranda, Hugo, Maiolino, Francesca, Guerreiro, Patrícia, Näsström, Thomas, Franquelim, Henri G, Oliveira, Luís M A, Castanho, Miguel A R B, Lannfelt, Lars, Bergström, Joakim, Ingelsson, Martin, Quintas, Alexandre, Sebastião, Ana M, Lopes, Luísa V, Outeiro, Tiago Fleming
Published in The Journal of neuroscience (22.08.2012)
Published in The Journal of neuroscience (22.08.2012)
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Journal Article
Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease
König, Annekatrin, Vicente Miranda, Hugo, Outeiro, Tiago Fleming
Published in Journal of Parkinson's disease (01.01.2018)
Published in Journal of Parkinson's disease (01.01.2018)
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Book Review
Journal Article
Dysmetabolism and Neurodegeneration: Trick or Treat?
Capucho, Adriana M, Chegão, Ana, Martins, Fátima O, Vicente Miranda, Hugo, Conde, Sílvia V
Published in Nutrients (29.03.2022)
Published in Nutrients (29.03.2022)
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Journal Article
Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes
Chegão, Ana, Guarda, Mariana, Alexandre, Bruno M, Shvachiy, Liana, Temido-Ferreira, Mariana, Marques-Morgado, Inês, Fernandes Gomes, Bárbara, Matthiesen, Rune, Lopes, Luísa V, Florindo, Pedro R, Gomes, Ricardo A, Gomes-Alves, Patrícia, Coelho, Joana E, Outeiro, Tiago Fleming, Vicente Miranda, Hugo
Published in NPJ Parkinson's Disease (25.04.2022)
Published in NPJ Parkinson's Disease (25.04.2022)
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Journal Article
Synthesis and Biological Evaluation of Novel 2‐Aryl Benzimidazoles as Chemotherapeutic Agents
Morais, Goreti Ribeiro, Palma, Elisa, Marques, Fernanda, Gano, Lurdes, Oliveira, Maria Cristina, Abrunhosa, Antero, Miranda, Hugo Vicente, Outeiro, Tiago F., Santos, Isabel, Paulo, Antonio
Published in Journal of heterocyclic chemistry (01.01.2017)
Published in Journal of heterocyclic chemistry (01.01.2017)
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Journal Article
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology
Belo, Rita F., Martins, Margarida L. F., Shvachiy, Liana, Costa-Coelho, Tiago, de Almeida-Borlido, Carolina, Fonseca-Gomes, João, Neves, Vera, Vicente Miranda, Hugo, Outeiro, Tiago F., Coelho, Joana E., Xapelli, Sara, Valente, Cláudia A., Heras, Montserrat, Bardaji, Eduard, Castanho, Miguel A. R. B., Diógenes, Maria José, Sebastião, Ana M.
Published in Frontiers in pharmacology (09.07.2020)
Published in Frontiers in pharmacology (09.07.2020)
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Journal Article
α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B
Ferreira, Diana G, Temido-Ferreira, Mariana, Vicente Miranda, Hugo, Batalha, Vânia L, Coelho, Joana E, Szegö, Éva M, Marques-Morgado, Inês, Vaz, Sandra H, Rhee, Jeong Seop, Schmitz, Matthias, Zerr, Inga, Lopes, Luísa V, Outeiro, Tiago F
Published in Nature neuroscience (01.11.2017)
Published in Nature neuroscience (01.11.2017)
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Journal Article
α-synuclein interacts with PrP C to induce cognitive impairment through mGluR5 and NMDAR2B
Ferreira, Diana G, Temido-Ferreira, Mariana, Vicente Miranda, Hugo, Batalha, Vânia L, Coelho, Joana E, Szegö, Éva M, Marques-Morgado, Inês, Vaz, Sandra H, Rhee, Jeong Seop, Schmitz, Matthias, Zerr, Inga, Lopes, Luísa V, Outeiro, Tiago F
Published in Nature neuroscience (01.11.2017)
Published in Nature neuroscience (01.11.2017)
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Journal Article
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases
Sousa, Luís, Guarda, Mariana, Meneses, Maria João, Macedo, M Paula, Vicente Miranda, Hugo
Published in The Journal of pathology (01.12.2021)
Published in The Journal of pathology (01.12.2021)
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Journal Article
Glycation in Parkinson's disease and Alzheimer's disease
Vicente Miranda, Hugo, El-Agnaf, Omar M. A., Outeiro, Tiago Fleming
Published in Movement disorders (01.06.2016)
Published in Movement disorders (01.06.2016)
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Journal Article
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
de Oliveira, Rita Machado, Vicente Miranda, Hugo, Francelle, Laetitia, Pinho, Raquel, Szegö, Éva M, Martinho, Renato, Munari, Francesca, Lázaro, Diana F, Moniot, Sébastien, Guerreiro, Patrícia, Fonseca-Ornelas, Luis, Marijanovic, Zrinka, Antas, Pedro, Gerhardt, Ellen, Enguita, Francisco Javier, Fauvet, Bruno, Penque, Deborah, Pais, Teresa Faria, Tong, Qiang, Becker, Stefan, Kügler, Sebastian, Lashuel, Hilal Ahmed, Steegborn, Clemens, Zweckstetter, Markus, Outeiro, Tiago Fleming
Published in PLoS biology (03.03.2017)
Published in PLoS biology (03.03.2017)
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Journal Article
Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity
Ferreira, Diana G, Batalha, Vânia L, Vicente Miranda, Hugo, Coelho, Joana E, Gomes, Rui, Gonçalves, Francisco Q, Real, Joana I, Rino, José, Albino-Teixeira, António, Cunha, Rodrigo A, Outeiro, Tiago F, Lopes, Luísa V
Published in Cerebral cortex (New York, N.Y. 1991) (01.01.2017)
Published in Cerebral cortex (New York, N.Y. 1991) (01.01.2017)
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Journal Article
Protein glycation and methylglyoxal metabolism in yeast: finding peptide needles in protein haystacks
Gomes, Ricardo Anjos, Miranda, Hugo Vicente, Sousa Silva, Marta, Graça, Gonçalo, Coelho, Ana Varela, do Nascimento Ferreira, António Eduardo, Cordeiro, Carlos, Freire, Ana Ponces
Published in FEMS yeast research (01.02.2008)
Published in FEMS yeast research (01.02.2008)
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Journal Article