Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization
Huggins, Matthew A., Sjaastad, Frances V., Pierson, Mark, Kucaba, Tamara A., Swanson, Whitney, Staley, Christopher, Weingarden, Alexa R., Jensen, Isaac J., Danahy, Derek B., Badovinac, Vladimir P., Jameson, Stephen C., Vezys, Vaiva, Masopust, David, Khoruts, Alexander, Griffith, Thomas S., Hamilton, Sara E.
Published in Cell reports (Cambridge) (13.08.2019)
Published in Cell reports (Cambridge) (13.08.2019)
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Journal Article
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells
Burrack, Kristina S., Huggins, Matthew A., Taras, Emily, Dougherty, Philip, Henzler, Christine M., Yang, Rendong, Alter, Sarah, Jeng, Emily K., Wong, Hing C., Felices, Martin, Cichocki, Frank, Miller, Jeffrey S., Hart, Geoffrey T., Johnson, Aaron J., Jameson, Stephen C., Hamilton, Sara E.
Published in Immunity (Cambridge, Mass.) (17.04.2018)
Published in Immunity (Cambridge, Mass.) (17.04.2018)
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Journal Article
Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8+ T cell responses
Malo, Courtney S., Huggins, Matthew A., Goddery, Emma N., Tolcher, Heather M. A., Renner, Danielle N., Jin, Fang, Hansen, Michael J., Pease, Larry R., Pavelko, Kevin D., Johnson, Aaron J.
Published in Nature communications (12.02.2018)
Published in Nature communications (12.02.2018)
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Journal Article
KLRG1 + Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory
Renkema, Kristin R, Huggins, Matthew A, Borges da Silva, Henrique, Knutson, Todd P, Henzler, Christy M, Hamilton, Sara E
Published in The Journal of immunology (1950) (15.08.2020)
Published in The Journal of immunology (1950) (15.08.2020)
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Journal Article
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells
Peng, Changwei, Huggins, Matthew A., Wanhainen, Kelsey M., Knutson, Todd P., Lu, Hanbin, Georgiev, Hristo, Mittelsteadt, Kristen L., Jarjour, Nicholas N., Wang, Haiguang, Hogquist, Kristin A., Campbell, Daniel J., Borges da Silva, Henrique, Jameson, Stephen C.
Published in Immunity (Cambridge, Mass.) (11.01.2022)
Published in Immunity (Cambridge, Mass.) (11.01.2022)
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Journal Article
Natural Microbial Exposure from the Earliest Natural Time Point Enhances Immune Development by Expanding Immune Cell Progenitors and Mature Immune Cells
Burger, Sarah, Stenger, Terran, Pierson, Mark, Sridhar, Adhvaith, Huggins, Matthew A, Kucaba, Tamara A, Griffith, Thomas S, Hamilton, Sara E, Schuldt, Nathaniel J
Published in The Journal of immunology (1950) (01.06.2023)
Published in The Journal of immunology (1950) (01.06.2023)
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Journal Article
Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8 + T cell subsets
Jarjour, Nicholas N, Wanhainen, Kelsey M, Peng, Changwei, Gavil, Noah V, Maurice, Nicholas J, Borges da Silva, Henrique, Martinez, Ryan J, Dalzell, Talia S, Huggins, Matthew A, Masopust, David, Hamilton, Sara E, Jameson, Stephen C
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2022)
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Journal Article
Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells
Sjaastad, Frances V, Huggins, Matthew A, Lucas, Erin D, Skon-Hegg, Cara, Swanson, Whitney, Martin, Matthew D, Salgado, Oscar C, Xu, Julie, Pierson, Mark, Dileepan, Thamotharampillai, Kucaba, Tamara A, Hamilton, Sara E, Griffith, Thomas S
Published in The Journal of immunology (1950) (01.12.2022)
Published in The Journal of immunology (1950) (01.12.2022)
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Journal Article
Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria
Huggins, Matthew A, Johnson, Holly L, Jin, Fang, N Songo, Aurelie, Hanson, Lisa M, LaFrance, Stephanie J, Butler, Noah S, Harty, John T, Johnson, Aaron J
Published in Infection and immunity (01.05.2017)
Published in Infection and immunity (01.05.2017)
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Journal Article
PD1 blockade improves survival and CD8 + cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice
Dahlquist, Korbyn J V, Huggins, Matthew A, Yousefzadeh, Matthew J, Soto-Palma, Carolina, Cholensky, Stephanie H, Pierson, Mark, Smith, Declan M, Hamilton, Sara E, Camell, Christina D
Published in Nature aging (01.07.2024)
Published in Nature aging (01.07.2024)
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Journal Article
Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident
Lucas, Erin D, Huggins, Matthew A, Peng, Changwei, O'Connor, Christine, Gress, Abigail R, Thefaine, Claire E, Dehm, Emma M, Kubota, Yoshiaki, Jameson, Stephen C, Hamilton, Sara E
Published in Science immunology (28.06.2024)
Published in Science immunology (28.06.2024)
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Journal Article
Senolytics reduce coronavirus-related mortality in old mice
Camell, Christina D, Yousefzadeh, Matthew J, Zhu, Yi, Prata, Larissa G P Langhi, Huggins, Matthew A, Pierson, Mark, Zhang, Lei, O'Kelly, Ryan D, Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J, Inman, Christina L, Johnson, Kurt O, Cholensky, Stephanie H, Carlson, Timothy W, LeBrasseur, Nathan K, Khosla, Sundeep, O'Sullivan, M Gerard, Allison, David B, Jameson, Stephen C, Meves, Alexander, Li, Ming, Prakash, Y S, Chiarella, Sergio E, Hamilton, Sara E, Tchkonia, Tamara, Niedernhofer, Laura J, Kirkland, James L, Robbins, Paul D
Published in Science (16.07.2021)
Published in Science (16.07.2021)
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Web Resource
Anti CD161 Antibody IMT-009 Is a Novel Immunotherapeutic Agent That Effectively Blocks the Inhibitory CLEC2D/CD161 Axis in CLEC2D+ B Cell Hematological Malignancies Reinvigorating T and NK Cell Function Leading to Anti-Tumor Benefit
Bernstein, Matthew, Scanlon, Elizabeth, Fusco, Alexandria, Irvine, Frano, Brown, Flavian D, Colbert, Jeffrey D, Huggins, Matthew A, Ross, Michael, Tang, Ming, Malu, Shruti
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
PD1 blockade improves survival during lethal microbial exposure in old mice
Dahlquist, Korbyn JV, Huggins, Matthew A, Yousefzadeh, Matthew J, Soto-Palma, Carolina, Cholensky, Stephanie H, Pierson, Mark, Hamilton, Sara E, Camell, Christina D
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
Conditional ablation of H-2Kb and H-2Db on discrete APC subsets modulate outcomes in experimental cerebral malaria
Fain, Cori E., Rana, Sabhya, Huggins, Matthew A, Malo, Courtney, Sieck, Gary C., Johnson, Aaron J
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
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