L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase
YOUNG, S. D, BRITCHER, S. F, PETTIBONE, D. J, O'BRIEN, J. A, BALL, R. G, BALANI, S. K, LIN, J. H, I-WU CHEN, SCHLEIF, W. A, SARDANA, V. V, LONG, W. J, BYRNES, V. W, TRAN, L. O, EMINI, E. A, PAYNE, L. S, LUMMA, W. C, LYLE, T. A, HUFF, J. R, ANDERSON, P. S, OLSEN, D. B, CARROLL, S. S
Published in Antimicrobial Agents and Chemotherapy (01.12.1995)
Published in Antimicrobial Agents and Chemotherapy (01.12.1995)
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L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor
Vacca, J. P., Dorsey, B. D., Schleif, W. A., Levin, R. B., McDaniel, S. L., Darke, P. L., Zugay, J., Quintero, J. C., Blahy, O. M., Roth, E., Sardana, V. V., Schlabach, A. J., Graham, P. I., Condra, J. H., Gotlib, L., Holloway, M. K., Lin, J., I.-W. Chen, Vastag, K., Ostovic, D., Anderson, P. S., Emini, E. A., Huff, J. R.
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.1994)
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A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066
CLINESCHMIDT, B. V, PETTIBONE, D. J, LOTTI, V. J, HUCKER, H. B, SWEENEY, B. M, REISS, D. R, LIS, E. V, HUFF, J. R, VACCA, J
Published in The Journal of pharmacology and experimental therapeutics (01.04.1988)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1988)
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Metabolism of synthetic inositol trisphosphate analogs
Polokoff, M A, Bencen, G H, Vacca, J P, deSolms, S J, Young, S D, Huff, J R
Published in The Journal of biological chemistry (25.08.1988)
Published in The Journal of biological chemistry (25.08.1988)
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Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency
Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beshore, Douglas C, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Miller, Patricia A, Omer, Charles A, Rodrigues, A. David, Walsh, Eileen S, Williams, Theresa M
Published in Journal of medicinal chemistry (30.08.2001)
Published in Journal of medicinal chemistry (30.08.2001)
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Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors
Dorsey, Bruce D, McDonough, Colleen, McDaniel, Stacey L, Levin, Rhonda B, Newton, Christina L, Hoffman, Jacob M, Darke, Paul L, Zugay-Murphy, Joan A, Emini, Emilio A, Schleif, William A, Olsen, David B, Stahlhut, Mark W, Rutkowski, Carrie A, Kuo, Lawrence C, Lin, Jiunn H, Chen, I-W, Michelson, Stuart R, Holloway, M. Katharine, Huff, Joel R, Vacca, Joseph P
Published in Journal of medicinal chemistry (07.09.2000)
Published in Journal of medicinal chemistry (07.09.2000)
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Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation
Ghosh, Arun K, Kincaid, John F, Walters, D. Eric, Chen, Yan, Chaudhuri, Narayan C, Thompson, Wayne J, Culberson, Chris, Fitzgerald, Paula M. D, Lee, Hee Yoon, McKee, Sean P, Munson, Peter M, Duong, Tien T, Darke, Paul L, Zugay, Joan A, Schleif, William A, Axel, Melinda G, Lin, Juinn, Huff, Joel R
Published in Journal of medicinal chemistry (16.08.1996)
Published in Journal of medicinal chemistry (16.08.1996)
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Structure-based design of HIV-1 protease inhibitors : replacement of two amides and a 10π-aromatic system by a fused bis-tetrahydrofuran
GHOSH, A. K, THOMPSON, W. J, FITZGERALD, P. M. D, CULBERSON, J. C, AXEL, M. G, MCKEE, S. P, HUFF, J. R, ANDERSON, P. S
Published in Journal of medicinal chemistry (05.08.1994)
Published in Journal of medicinal chemistry (05.08.1994)
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L-687,908, a potent hydroxyethylene containing HIV protease inhibitor
Vacca, Joseph P, Guare, J. P, DeSolms, S. J, Sanders, W. M, Giuliani, E. A, Young, S. D, Darke, P. L, Sigal, I. S, Schleif, W. A
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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3'-Tetrahydrofuranylglycine as a novel, unnatural amino acid surrogate for asparagine in the design of inhibitors of the HIV protease
Thompson, Wayne J, Ghosh, Arun K, Holloway, M. Katharine, Lee, Hee Yoon, Munson, Peter M, Schwering, John E, Wai, Jenny, Darke, Paul L, Zugay, Joan
Published in Journal of the American Chemical Society (01.01.1993)
Published in Journal of the American Chemical Society (01.01.1993)
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Conformationally constrained HIV-1 protease inhibitors
Vacca, J.P., Fitzgerald, P.M.D., Holloway, M.K., Hungate, R.W., Starbuck, K.E., Chen, L.J., Darke, P.L., Anderson, P.S., Huff, J.R.
Published in Bioorganic & medicinal chemistry letters (10.02.1994)
Published in Bioorganic & medicinal chemistry letters (10.02.1994)
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Bioactive conformation of 1-arylpiperazines at central serotonin receptors
Huff, Joel R, King, Stella W, Saari, Walfred S, Springer, J. P, Martin, Gregory E, Williams, Michael
Published in Journal of medicinal chemistry (01.07.1985)
Published in Journal of medicinal chemistry (01.07.1985)
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Structure-affinity relationships of arylquinolizines at .alpha.-adrenoceptors
Huff, Joel R, Baldwin, John J, DeSolms, S. Jane, Guare, James P, Hunt, Cecilia A, Randall, William C, Sanders, William S, Smith, Steven J, Vacca, Joseph P, Zrada, Matthew M
Published in Journal of medicinal chemistry (01.03.1988)
Published in Journal of medicinal chemistry (01.03.1988)
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L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR
DORSEY, BD, LEVIN, RB, MCDANIEL, SL, VACCA, JP, GUARE, JP, DARKE, PL, ZUGAY, JA, EMINI, EA, SCHLEIF, WA, QUINTERO, JC, LIN, JH, CHEN, IW, HOLLOWAY, MK, FITZGERALD, PMD, AXEL, MG, OSTOVIC, D, ANDERSON, PS, HUFF
Published in Journal of medicinal chemistry (14.10.1994)
Published in Journal of medicinal chemistry (14.10.1994)
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Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist
Duggan, ME, Duong, LT, Fisher, JE, Hamill, TG, Hoffman, WF, Huff, Ihle, NC, Leu, CT, Nagy, RM, Perkins, JJ, Rodan, SB, Wesolowski, G, Whitman, DB, Zartman, AE, Rodan, GA, Hartman, GD
Published in Journal of medicinal chemistry (05.10.2000)
Published in Journal of medicinal chemistry (05.10.2000)
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