Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets
Varešlija, Damir, Priedigkeit, Nolan, Fagan, Ailís, Purcell, Siobhan, Cosgrove, Nicola, O'Halloran, Philip J, Ward, Elspeth, Cocchiglia, Sinéad, Hartmaier, Ryan, Castro, Carlos A, Zhu, Li, Tseng, George C, Lucas, Peter C, Puhalla, Shannon L, Brufsky, Adam M, Hamilton, Ronald L, Mathew, Aju, Leone, Jose P, Basudan, Ahmed, Hudson, Lance, Dwyer, Róisín, Das, Sudipto, O'Connor, Darran P, Buckley, Patrick G, Farrell, Michael, Hill, Arnold D K, Oesterreich, Steffi, Lee, Adrian V, Young, Leonie S
Published in JNCI : Journal of the National Cancer Institute (01.04.2019)
Published in JNCI : Journal of the National Cancer Institute (01.04.2019)
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Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings
Leech, Astrid O, Vellanki, Sri HariKrishna, Rutherford, Emily J, Keogh, Aoife, Jahns, Hanne, Hudson, Lance, O'Donovan, Norma, Sabri, Siham, Abdulkarim, Bassam, Sheehan, Katherine M, Kay, Elaine W, Young, Leonie S, Hill, Arnold D K, Smith, Yvonne E, Hopkins, Ann M
Published in Breast cancer research : BCR (20.11.2018)
Published in Breast cancer research : BCR (20.11.2018)
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Protein Tyrosine Phosphatase Non-Receptor 11 ( PTPN11 /Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)
Richards, Cathy E, Elamin, Yasir Y, Carr, Aoife, Gately, Kathy, Rafee, Shereen, Cremona, Mattia, Hanrahan, Emer, Smyth, Robert, Ryan, Daniel, Morgan, Ross K, Kennedy, Susan, Hudson, Lance, Fay, Joanna, O'Byrne, Kenneth, Hennessy, Bryan T, Toomey, Sinead
Published in International journal of molecular sciences (23.06.2023)
Published in International journal of molecular sciences (23.06.2023)
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Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation
Juric, Viktorija, Hudson, Lance, Fay, Joanna, Richards, Cathy E., Jahns, Hanne, Verreault, Maïté, Bielle, Franck, Idbaih, Ahmed, Lamfers, Martine L. M., Hopkins, Ann M., Rehm, Markus, Murphy, Brona M.
Published in Cell death & disease (03.08.2021)
Published in Cell death & disease (03.08.2021)
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Dynamic epi‐transcriptomic landscape mapping with disease progression in estrogen receptor‐positive breast cancer
Keelan, Stephen, Ola, Mihaela, Charmsaz, Sara, Cocchiglia, Sinéad, Ottaviani, Daniela, Hickey, Seán, Purcell, Siobhan, Bane, Fiona, Hegarty, Aisling, Doherty, Ben, Sheehan, Katherine, Hudson, Lance, Cosgrove, Nicola, Roux, Benjamin, Laine, Muriel, Greene, Geoffrey, Varešlija, Damir, Hill, Arnold Konrad, Young, Leonie
Published in Cancer communications (London, England) (01.05.2023)
Published in Cancer communications (London, England) (01.05.2023)
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An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models
Donatello, Simona, Hudson, Lance, Cottell, David C, Blanco, Alfonso, Aurrekoetxea, Igor, Shelly, Martin J, Dervan, Peter A, Kell, Malcolm R, Stokes, Maurice, Hill, Arnold D K, Hopkins, Ann M
Published in Journal of experimental & clinical cancer research (26.04.2011)
Published in Journal of experimental & clinical cancer research (26.04.2011)
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Journal Article
Protein Tyrosine Phosphatase Non-Receptor 11
Richards, Cathy E, Elamin, Yasir Y, Carr, Aoife, Gately, Kathy, Rafee, Shereen, Cremona, Mattia, Hanrahan, Emer, Smyth, Robert, Ryan, Daniel, Morgan, Ross K, Kennedy, Susan, Hudson, Lance, Fay, Joanna, O’Byrne, Kenneth, Hennessy, Bryan T, Toomey, Sinead
Published in International journal of molecular sciences (01.06.2023)
Published in International journal of molecular sciences (01.06.2023)
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Journal Article
Natural compound Tetrocarcin-A downregulates Junctional Adhesion Molecule-A in conjunction with HER2 and inhibitor of apoptosis proteins and inhibits tumor cell growth
Vellanki, Sri HariKrishna, Cruz, Rodrigo G.B., Jahns, Hanne, Hudson, Lance, Sette, Giovanni, Eramo, Adriana, Hopkins, Ann M.
Published in Cancer letters (01.01.2019)
Published in Cancer letters (01.01.2019)
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Abstract P3-06-01: Junctional adhesion molecule-A (JAM-A) as a novel future drug target in ductal carcinoma in situ (DCIS)
Hopkins, Ann M, Smith, Yvonne E., Wang, Guannan, Flynn, Ciara, Casucci, Alexander, Vellanki, Sri HariKrishna, Hudson, Lance, Brennan, Kieran, Cremona, Mattia, Sukumar, Saraswati
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Abstract 2670: Natural compound tetrocarcin-A downregulates junctional adhesion molecule-A in conjunction with erα, her2 and inhibitor of apoptosis proteins and inhibits tumor cell growth
Vellanki, Sri Harikrishna, Hudson, Lance, Jahns, Hanne, Cruz, Rodrigo G.B., Sette, Giovanni, Eramo, Adriana, Hopkins, Ann M.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer
Browne, Alacoque L., Charmsaz, Sara, Varešlija, Damir, Fagan, Ailis, Cosgrove, Nicola, Cocchiglia, Sinéad, Purcell, Siobhan, Ward, Elspeth, Bane, Fiona, Hudson, Lance, Hill, Arnold D., Carroll, Jason S., Redmond, Aisling M., Young, Leonie S.
Published in Oncogene (01.04.2018)
Published in Oncogene (01.04.2018)
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Antibiotic Tetrocarcin-A Down-regulates JAM-A, IAPs and Induces Apoptosis in Triple-negative Breast Cancer Models
Vellanki, Sri Harikrishna, Cruz, Rodrigo G B, Richards, Cathy E, Smith, Yvonne E, Hudson, Lance, Jahns, Hanne, Hopkins, Ann M
Published in Anticancer research (01.03.2019)
Published in Anticancer research (01.03.2019)
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Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype
Varešlija, Damir, Ward, Elspeth, Purcell, Siobhan P., Cosgrove, Nicola S., Cocchiglia, Sinéad, O’Halloran, Philip J., Charmsaz, Sara, Bane, Fiona T., Brett, Francesca M., Farrell, Michael, Cryan, Jane, Beausang, Alan, Hudson, Lance, Turnbul, Arran K., Dixon, J. Michael, Hill, Arnold D. K., Priedigkeit, Nolan, Oesterreich, Steffi, Lee, Adrian V., Sims, Andrew H., Redmond, Aisling M., Carroll, Jason S., Young, Leonie S.
Published in Oncogene (18.02.2021)
Published in Oncogene (18.02.2021)
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Epigenome-wide SRC-1-Mediated Gene Silencing Represses Cellular Differentiation in Advanced Breast Cancer
Ward, Elspeth, Varešlija, Damir, Charmsaz, Sara, Fagan, Ailis, Browne, Alacoque L, Cosgrove, Nicola, Cocchiglia, Sinéad, Purcell, Siobhan P, Hudson, Lance, Das, Sudipto, O'Connor, Darran, O'Halloran, Philip J, Sims, Andrew H, Hill, Arnold D, Young, Leonie S
Published in Clinical cancer research (01.08.2018)
Published in Clinical cancer research (01.08.2018)
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Journal Article
Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors
Varešlija, Damir, McBryan, Jean, Fagan, Ailís, Redmond, Aisling M, Hao, Yuan, Sims, Andrew H, Turnbull, Arran, Dixon, J M, Ó Gaora, Peadar, Hudson, Lance, Purcell, Siobhan, Hill, Arnold D K, Young, Leonie S
Published in Clinical cancer research (01.06.2016)
Published in Clinical cancer research (01.06.2016)
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Journal Article
Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy
McBryan, Jean, Fagan, Ailís, McCartan, Damian, Bane, Fiona T, Varešlija, Damir, Cocchiglia, Sinéad, Byrne, Christopher, Bolger, Jarlath, McIlroy, Marie, Hudson, Lance, Tibbitts, Paul, Gaora, Peadar Ó, Hill, Arnold D, Young, Leonie S
Published in Clinical cancer research (01.12.2015)
Published in Clinical cancer research (01.12.2015)
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