Search Results - "Hudkins, Robert L" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery and Characterization of 6-{4-[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H3 Receptor Inverse Agonist

Discovery and Characterization of 6-{4-[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H3 Receptor Inverse Agonist

by Hudkins, Robert L, Raddatz, Rita, Tao, Ming, Mathiasen, Joanne R, Aimone, Lisa D, Becknell, Nadine C, Prouty, Catherine P, Knutsen, Lars J. S, Yazdanian, Mehran, Moachon, Gilbert, Ator, Mark A, Mallamo, John P, Marino, Michael J, Bacon, Edward R, Williams, Michael
Published in Journal of medicinal chemistry (14.07.2011)

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Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors

Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors

by Angeles, Thelma S, Hudkins, Robert L
Published in Expert opinion on drug discovery (01.12.2016)

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Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells

Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells

by Wan, Weihua, Albom, Mark S., Lu, Lihui, Quail, Matthew R., Becknell, Nadine C., Weinberg, Linda R., Reddy, Dandu R., Holskin, Beverly P., Angeles, Thelma S., Underiner, Ted L., Meyer, Sheryl L., Hudkins, Robert L., Dorsey, Bruce D., Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng
Published in Blood (15.02.2006)

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Synthesis and Mixed Lineage Kinase Activity of Pyrrolocarbazole and Isoindolone Analogs of (+)K-252a

Synthesis and Mixed Lineage Kinase Activity of Pyrrolocarbazole and Isoindolone Analogs of (+)K-252a

by Hudkins, Robert L, Johnson, Neil W, Angeles, Thelma S, Gessner, George W, Mallamo, John P
Published in Journal of medicinal chemistry (08.02.2007)

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Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

by Shraga, Amit, Olshvang, Evgenia, Davidzohn, Natalia, Khoshkenar, Payam, Germain, Nicolas, Shurrush, Khriesto, Carvalho, Silvia, Avram, Liat, Albeck, Shira, Unger, Tamar, Lefker, Bruce, Subramanyam, Chakrapani, Hudkins, Robert L, Mitchell, Amir, Shulman, Ziv, Kinoshita, Takayoshi, London, Nir
Published in Cell chemical biology (17.01.2019)

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Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia

Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia

by Hudkins, Robert L., Allen, Eric, Balcer, Alexandra, Hoffman, Isaac D., Iyer, Samhita, Neal, Melissa, Nelson, Kirk J., Rideout, Marc, Ye, Qing, Starrett, Jacqueline H., Patel, Piyush, Harris, Todd, Swanson, Ronald V., Bensen, Daniel C.
Published in Journal of medicinal chemistry (11.09.2024)

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A FACILE AND EFFICIENT SYNTHESIS OF 3-AMINO-5-BROMOPYRIDINE DERIVATIVES USING MICROWAVE IRRADIATION

A FACILE AND EFFICIENT SYNTHESIS OF 3-AMINO-5-BROMOPYRIDINE DERIVATIVES USING MICROWAVE IRRADIATION

by Dandu, Reddeppa Reddy, Rose, Adam C., Hudkins, Robert L.
Published in Heterocycles (01.04.2011)

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Technically Extended MultiParameter Optimization (TEMPO): An Advanced Robust Scoring Scheme To Calculate Central Nervous System Druggability and Monitor Lead Optimization

Technically Extended MultiParameter Optimization (TEMPO): An Advanced Robust Scoring Scheme To Calculate Central Nervous System Druggability and Monitor Lead Optimization

by Ghose, Arup K, Ott, Gregory R, Hudkins, Robert L
Published in ACS chemical neuroscience (18.01.2017)

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Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives

Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives

by Kaneko, Masami, Saito, Yutaka, Saito, Hiromitsu, Matsumoto, Tadashi, Matsuda, Yuzuru, Vaught, Jeffry L, Dionne, Craig A, Angeles, Thelma S, Glicksman, Marcie A, Neff, Nicola T, Rotella, David P, Kauer, James C, Mallamo, John P, Hudkins, Robert L, Murakata, Chikara
Published in Journal of medicinal chemistry (06.06.1997)

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Synthesis and Biological Profile of the pan-Vascular Endothelial Growth Factor Receptor/Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor-Like Homology Domains 2 (VEGF-R/TIE-2) Inhibitor 11-(2-Methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): A Novel Oncology Therapeutic Agent

by Hudkins, Robert L, Becknell, Nadine C, Zulli, Allison L, Underiner, Ted L, Angeles, Thelma S, Aimone, Lisa D, Albom, Mark S, Chang, Hong, Miknyoczki, Sheila J, Hunter, Kathryn, Jones-Bolin, Susan, Zhao, Hugh, Bacon, Edward R, Mallamo, John P, Ator, Mark A, Ruggeri, Bruce A
Published in Journal of medicinal chemistry (26.01.2012)

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Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

by Ghose, Arup K, Herbertz, Torsten, Hudkins, Robert L, Dorsey, Bruce D, Mallamo, John P
Published in ACS chemical neuroscience (18.01.2012)

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3-(1′-Cyclobutylspiro[4H-1,3-benzodioxine-2,4′-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist

3-(1′-Cyclobutylspiro[4H-1,3-benzodioxine-2,4′-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist

by Hudkins, Robert L., Gruner, John A., Raddatz, Rita, Mathiasen, Joanne R., Aimone, Lisa D., Marino, Michael J., Bacon, Edward R., Williams, Michael, Ator, Mark A.
Published in Neuropharmacology (01.07.2016)

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아미노피리미딘 화합물 및 그의 사용 방법

아미노피리미딘 화합물 및 그의 사용 방법

by HUDKINS ROBERT L, BENSEN DANIEL C
Year of Publication 08.11.2023

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Patent

키나아제 억제제로서의 인다졸 화합물

키나아제 억제제로서의 인다졸 화합물

by HUDKINS ROBERT L, BENSEN DANIEL C
Year of Publication 03.11.2023

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Patent

Current approaches for the treatment of cognitive deficits in CNS disease

Current approaches for the treatment of cognitive deficits in CNS disease

by Hudkins, Robert L
Published in Current topics in medicinal chemistry (01.02.2010)

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Journal Article

3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity

3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity

by Hudkins, Robert L., Becknell, Nadine C., Lyons, Jacquelyn A., Aimone, Lisa D., Olsen, Mark, Haltiwanger, R. Curtis, Mathiasen, Joanne R., Raddatz, Rita, Gruner, John A.
Published in European journal of medicinal chemistry (05.05.2015)

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Development and Scale-Up of an Optimized Route to the Pyridazin-3-one Histamine H3 Receptor Antagonist CEP-32215

Development and Scale-Up of an Optimized Route to the Pyridazin-3-one Histamine H3 Receptor Antagonist CEP-32215

by Wang, Yi, Przyuski, Katrin, Roemmele, Renee C, Hudkins, Robert L, Bakale, Roger P
Published in Organic process research & development (17.05.2013)

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Discovery of (1R, 6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]3,4-diaza-bicyclo[4.1.0] hept-4-en-2-one (R, S-4a): Histamine H3 receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity

Discovery of (1R, 6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]3,4-diaza-bicyclo[4.1.0] hept-4-en-2-one (R, S-4a): Histamine H3 receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity

by Hudkins, Robert L., Josef, Kurt A., Becknell, Nadine C., Aimone, Lisa D., Lyons, Jacquelyn A., Mathiasen, Joanne R., Gruner, John A., Raddatz, Rita
Published in Bioorganic & medicinal chemistry letters (01.03.2014)

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Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists

Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists

by Josef, Kurt A., Aimone, Lisa D., Lyons, Jacquelyn, Raddatz, Rita, Hudkins, Robert L.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)

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Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

by Zulli, Allison L., Aimone, Lisa D., Mathiasen, Joanne R., Gruner, John A., Raddatz, Rita, Bacon, Edward R., Hudkins, Robert L.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)

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