Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies
Fer, Mickael, Amalric, Camille, Arban, Roberto, Baron, Luc, Ben Hamida, Sami, Breh-Schlanser, Petra, Cui, Yunhai, Darcq, Emmanuel, Eickmeier, Christian, Faye, Vincent, Franchet, Christel, Frauli, Mélanie, Halter, Célia, Heyer, Marjorie, Hoenke, Christoph, Hoerer, Stefan, Hucke, Oliver T., Joseph, Christophe, Kieffer, Brigitte L., Lebrun, Louison, Lotz, Noémie, Mayer, Stanislas, Omrani, Azar, Recolet, Mandy, Schaeffer, Laurent, Schann, Stephan, Schlecker, Annette, Steinberg, Edith, Viloria, Mélanie, Würstle, Klaus, Young, Kyle, Zinser, Alexander, Montel, Florian, Klepp, Julian
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Journal Article
Revealing Atropisomer Axial Chirality in Drug Discovery
LaPlante, Steven R., Edwards, Paul J., Fader, Lee D., Jakalian, Araz, Hucke, Oliver
Published in ChemMedChem (07.03.2011)
Published in ChemMedChem (07.03.2011)
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Journal Article
Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo
SPICKLER, Catherine, LIPPENS, Julie, VAILLANCOURT, Fréderic H, DECOR, Anne, O'MEARA, Jeff, FRANTI, Michael, GAUTHIER, Annick, LABERGE, Marie-Kristine, DESMEULES, Sophie, BELLAVANCE, Edith, GARNEAU, Michel, GUO, Tim, HUCKE, Oliver, LEYSSEN, Pieter, NEYTS, Johan
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
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Journal Article
Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity
LaPlante, Steven R., Forgione, Pat, Boucher, Colette, Coulombe, René, Gillard, James, Hucke, Oliver, Jakalian, Araz, Joly, Marc-André, Kukolj, George, Lemke, Christopher, McCollum, Robert, Titolo, Steve, Beaulieu, Pierre L., Stammers, Timothy
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly
Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
Tremblay, Martin, Bonneau, Pierre, Bousquet, Yves, DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Goudreau, Nathalie, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lemke, Christopher T., Mason, Stephen W., Simoneau, Bruno, Surprenant, Simon, Titolo, Steve, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Resistance to a Protein Farnesyltransferase Inhibitor in Plasmodium falciparum
Eastman, Richard T., White, John, Hucke, Oliver, Bauer, Kevin, Yokoyama, Kohei, Nallan, Laxman, Chakrabarti, Debopam, Verlinde, Christophe L.M.J., Gelb, Michael H., Rathod, Pradipsinh K., Van Voorhis, Wesley C.
Published in The Journal of biological chemistry (08.04.2005)
Published in The Journal of biological chemistry (08.04.2005)
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Journal Article
Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase
Van Voorhis, Wesley C, Rivas, Kasey L, Bendale, Pravin, Nallan, Laxman, Hornéy, Carolyn, Barrett, Lynn K, Bauer, Kevin D, Smart, Brian P, Ankala, Sudha, Hucke, Oliver, Verlinde, Christophe L M J, Chakrabarti, Debopam, Strickland, Corey, Yokoyama, Kohei, Buckner, Frederick S, Hamilton, Andrew D, Williams, David K, Lombardo, Louis J, Floyd, David, Gelb, Michael H
Published in Antimicrobial Agents and Chemotherapy (01.10.2007)
Published in Antimicrobial Agents and Chemotherapy (01.10.2007)
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Journal Article
Action of Dipeptidyl Peptidase‐4 Inhibitors on SARS‐CoV‐2 Main Protease
Nar, Herbert, Schnapp, Gisela, Hucke, Oliver, Hardman, Timothy C., Klein, Thomas
Published in ChemMedChem (06.05.2021)
Published in ChemMedChem (06.05.2021)
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Journal Article
Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor
Saleh, Noureldin, Hucke, Oliver, Kramer, Gert, Schmidt, Esther, Montel, Florian, Lipinski, Radoslaw, Ferger, Boris, Clark, Timothy, Hildebrand, Peter W., Tautermann, Christofer S.
Published in Angewandte Chemie International Edition (01.03.2018)
Published in Angewandte Chemie International Edition (01.03.2018)
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Journal Article
Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions
Sedykh, Alexander, Fourches, Denis, Duan, Jianmin, Hucke, Oliver, Garneau, Michel, Zhu, Hao, Bonneau, Pierre, Tropsha, Alexander
Published in Pharmaceutical research (01.04.2013)
Published in Pharmaceutical research (01.04.2013)
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Journal Article
Discovery and Structural Characterization of a New Inhibitor Series of HIV-1 Nucleocapsid Function: NMR Solution Structure Determination of a Ternary Complex Involving a 2:1 Inhibitor/NC Stoichiometry
Goudreau, Nathalie, Hucke, Oliver, Faucher, Anne-Marie, Grand-Maître, Chantal, Lepage, Olivier, Bonneau, Pierre R., Mason, Stephen W., Titolo, Steve
Published in Journal of molecular biology (12.06.2013)
Published in Journal of molecular biology (12.06.2013)
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Journal Article
Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335
Lemke, Christopher T., Goudreau, Nathalie, Zhao, Songping, Hucke, Oliver, Thibeault, Diane, Llinàs-Brunet, Montse, White, Peter W.
Published in The Journal of biological chemistry (01.04.2011)
Published in The Journal of biological chemistry (01.04.2011)
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Journal Article
Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency
Hucke, Oliver, Coulombe, René, Bonneau, Pierre, Bertrand-Laperle, Mégan, Brochu, Christian, Gillard, James, Joly, Marc-André, Landry, Serge, Lepage, Olivier, Llinàs-Brunet, Montse, Pesant, Marc, Poirier, Martin, Poirier, Maude, McKercher, Ginette, Marquis, Martin, Kukolj, George, Beaulieu, Pierre L., Stammers, Timothy A.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: Addressing configurational instability through scaffold modification
Fader, Lee D., Landry, Serge, Morin, Sébastien, Kawai, Stephen H., Bousquet, Yves, Hucke, Oliver, Goudreau, Nathalie, Lemke, Christopher T., Bonneau, Pierre, Titolo, Steve, Mason, Stephen, Simoneau, Bruno
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Journal Article
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype
Beaulieu, Pierre L., Coulombe, René, Duan, Jianmin, Fazal, Gulrez, Godbout, Cédrickx, Hucke, Oliver, Jakalian, Araz, Joly, Marc-André, Lepage, Olivier, Llinàs-Brunet, Montse, Naud, Julie, Poirier, Martin, Rioux, Nathalie, Thavonekham, Bounkham, Kukolj, George, Stammers, Timothy A.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
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Journal Article
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: Structure–activity relationships (SAR) of the C3-phenyl moiety
Fader, Lee D., Landry, Serge, Goulet, Sylvie, Morin, Sébastien, Kawai, Stephen H., Bousquet, Yves, Dion, Isabelle, Hucke, Oliver, Goudreau, Nathalie, Lemke, Christopher T., Rancourt, Jean, Bonneau, Pierre, Titolo, Steve, Amad, Ma’an, Garneau, Michel, Duan, Jianmin, Mason, Stephen, Simoneau, Bruno
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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