Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning
Huber, Andrew D., Wright, William C., Lin, Wenwei, Majumder, Kinjal, Low, Jonathan A., Wu, Jing, Buchman, Cameron D., Pintel, David J., Chen, Taosheng
Published in Cellular and molecular life sciences : CMLS (01.01.2021)
Published in Cellular and molecular life sciences : CMLS (01.01.2021)
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Journal Article
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
Garcia-Maldonado, Efren, Huber, Andrew D., Chai, Sergio C., Nithianantham, Stanley, Li, Yongtao, Wu, Jing, Poudel, Shyaron, Miller, Darcie J., Seetharaman, Jayaraman, Chen, Taosheng
Published in Nature communications (14.05.2024)
Published in Nature communications (14.05.2024)
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Journal Article
Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5
Wright, William C, Chenge, Jude, Wang, Jingheng, Girvan, Hazel M, Yang, Lei, Chai, Sergio C, Huber, Andrew D, Wu, Jing, Oladimeji, Peter O, Munro, Andrew W, Chen, Taosheng
Published in Journal of medicinal chemistry (13.02.2020)
Published in Journal of medicinal chemistry (13.02.2020)
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Journal Article
Multiplex single-cell visualization of nucleic acids and protein during HIV infection
Puray-Chavez, Maritza, Tedbury, Philip R., Huber, Andrew D., Ukah, Obiaara B., Yapo, Vincent, Liu, Dandan, Ji, Juan, Wolf, Jennifer J., Engelman, Alan N., Sarafianos, Stefan G.
Published in Nature communications (01.12.2017)
Published in Nature communications (01.12.2017)
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Journal Article
Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus
Liu, Dandan, Ndongwe, Tanya P, Ji, Juan, Huber, Andrew D, Michailidis, Eleftherios, Rice, Charles M, Ralston, Robert, Tedbury, Philip R, Sarafianos, Stefan G
Published in Viruses (01.04.2023)
Published in Viruses (01.04.2023)
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Journal Article
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase
Kirby, Karen A, Myshakina, Nataliya A, Christen, Martin T, Chen, Yue-Lei, Schmidt, Hilary A, Huber, Andrew D, Xi, Zhaoyong, Kim, Seongmi, Rao, Rohit K, Kramer, Skyler T, Yang, Qiongying, Singh, Kamalendra, Parniak, Michael A, Wang, Zhengqiang, Ishima, Rieko, Sarafianos, Stefan G
Published in Antimicrobial agents and chemotherapy (01.10.2017)
Published in Antimicrobial agents and chemotherapy (01.10.2017)
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Journal Article
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation
Florke Gee, Rebecca R., Huber, Andrew D., Wu, Jing, Bajpai, Richa, Loughran, Allister J., Pruett-Miller, Shondra M., Chen, Taosheng
Published in Acta pharmaceutica Sinica. B (01.11.2023)
Published in Acta pharmaceutica Sinica. B (01.11.2023)
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Journal Article
CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer
Shao, Ming, Pan, Qingfei, Tan, Haiyan, Wu, Jing, Lee, Ha Won, Huber, Andrew D., Wright, William C., Cho, Ji-Hoon, Yu, Jiyang, Peng, Junmin, Chen, Taosheng
Published in Genes & diseases (01.07.2024)
Published in Genes & diseases (01.07.2024)
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Journal Article
Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus
Liu, Dandan, Tedbury, Philip R, Lan, Shuiyun, Huber, Andrew D, Puray-Chavez, Maritza N, Ji, Juan, Michailidis, Eleftherios, Saeed, Mohsan, Ndongwe, Tanyaradzwa P, Bassit, Leda C, Schinazi, Raymond F, Ralston, Robert, Rice, Charles M, Sarafianos, Stefan G
Published in Viruses (08.11.2019)
Published in Viruses (08.11.2019)
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Journal Article
Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication
Puray-Chavez, Maritza N, Farghali, Mahmoud H, Yapo, Vincent, Huber, Andrew D, Liu, Dandan, Ndongwe, Tanyaradzwa P, Casey, Mary C, Laughlin, Thomas G, Hannink, Mark, Tedbury, Philip R, Sarafianos, Stefan G
Published in Viruses (17.07.2019)
Published in Viruses (17.07.2019)
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Journal Article
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
Michailidis, Eleftherios, Ryan, Emily M, Hachiya, Atsuko, Kirby, Karen A, Marchand, Bruno, Leslie, Maxwell D, Huber, Andrew D, Ong, Yee T, Jackson, Jacob C, Singh, Kamalendra, Kodama, Eiichi N, Mitsuya, Hiroaki, Parniak, Michael A, Sarafianos, Stefan G
Published in Retrovirology (24.06.2013)
Published in Retrovirology (24.06.2013)
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Journal Article
The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells
Huber, Andrew D, Wolf, Jennifer J, Liu, Dandan, Gres, Anna T, Tang, Jing, Boschert, Kelsey N, Puray-Chavez, Maritza N, Pineda, Dallas L, Laughlin, Thomas G, Coonrod, Emily M, Yang, Qiongying, Ji, Juan, Kirby, Karen A, Wang, Zhengqiang, Sarafianos, Stefan G
Published in mSphere (25.04.2018)
Published in mSphere (25.04.2018)
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Journal Article
Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein
Lin, Wenwei, Huber, Andrew D, Poudel, Shyaron, Li, Yongtao, Seetharaman, Jayaraman, Miller, Darcie J, Chen, Taosheng
Published in Proceedings of the National Academy of Sciences - PNAS (07.03.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (07.03.2023)
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Journal Article
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand
Huber, Andrew D, Poudel, Shyaron, Li, Yongtao, Lin, Wenwei, Wu, Jing, Miller, Darcie J, Chen, Taosheng
Published in Structure (London) (07.12.2023)
Published in Structure (London) (07.12.2023)
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Journal Article
CITCO Directly Binds to and Activates Human Pregnane X Receptor
Lin, Wenwei, Bwayi, Monicah, Wu, Jing, Li, Yongtao, Chai, Sergio C, Huber, Andrew D, Chen, Taosheng
Published in Molecular pharmacology (01.03.2020)
Published in Molecular pharmacology (01.03.2020)
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