sgRNAcas9: a software package for designing CRISPR sgRNA and evaluating potential off-target cleavage sites
Xie, Shengsong, Shen, Bin, Zhang, Chaobao, Huang, Xingxu, Zhang, Yonglian
Published in PloS one (23.06.2014)
Published in PloS one (23.06.2014)
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Enhancement of prime editing via xrRNA motif-joined pegRNA
Zhang, Guiquan, Liu, Yao, Huang, Shisheng, Qu, Shiyuan, Cheng, Daolin, Yao, Yuan, Ji, Quanjiang, Wang, Xiaolong, Huang, Xingxu, Liu, Jianghuai
Published in Nature communications (06.04.2022)
Published in Nature communications (06.04.2022)
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Enhancing prime editing by Csy4-mediated processing of pegRNA
Liu, Yao, Yang, Guang, Huang, Shuhong, Li, Xiangyang, Wang, Xin, Li, Guanglei, Chi, Tian, Chen, Yulin, Huang, Xingxu, Wang, Xiaolong
Published in Cell research (01.10.2021)
Published in Cell research (01.10.2021)
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Next-generation pathogen diagnosis with CRISPR/Cas-based detection methods
Wang, Xinjie, Shang, Xiaoyun, Huang, Xingxu
Published in Emerging microbes & infections (01.01.2020)
Published in Emerging microbes & infections (01.01.2020)
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3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis
Ke, Yuwen, Xu, Yanan, Chen, Xuepeng, Feng, Songjie, Liu, Zhenbo, Sun, Yaoyu, Yao, Xuelong, Li, Fangzhen, Zhu, Wei, Gao, Lei, Chen, Haojie, Du, Zhenhai, Xie, Wei, Xu, Xiaocui, Huang, Xingxu, Liu, Jiang
Published in Cell (13.07.2017)
Published in Cell (13.07.2017)
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YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma
Hou, Jiajie, Zhang, He, Liu, Jun, Zhao, Zhenjun, Wang, Jianye, Lu, Zhike, Hu, Bian, Zhou, Jiankui, Zhao, Zhicong, Feng, Mingxuan, Zhang, Haiyan, Shen, Bin, Huang, Xingxu, Sun, Beicheng, Smyth, Mark J, He, Chuan, Xia, Qiang
Published in Molecular cancer (18.11.2019)
Published in Molecular cancer (18.11.2019)
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Correction of the Marfan Syndrome Pathogenic FBN1 Mutation by Base Editing in Human Cells and Heterozygous Embryos
Zeng, Yanting, Li, Jianan, Li, Guanglei, Huang, Shisheng, Yu, Wenxia, Zhang, Yu, Chen, Dunjin, Chen, Jia, Liu, Jianqiao, Huang, Xingxu
Published in Molecular therapy (07.11.2018)
Published in Molecular therapy (07.11.2018)
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Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
Li, Jianan, Yu, Wenxia, Huang, Shisheng, Wu, Susu, Li, Liping, Zhou, Jiankui, Cao, Yu, Huang, Xingxu, Qiao, Yunbo
Published in Nature communications (16.04.2021)
Published in Nature communications (16.04.2021)
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IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages
Rao, Li-Zong, Wang, Yi, Zhang, Lei, Wu, Guorao, Zhang, Lu, Wang, Fa-Xi, Chen, Long-Min, Sun, Fei, Jia, Song, Zhang, Shu, Yu, Qilin, Wei, Jiang-Hong, Lei, Hui-Ren, Yuan, Ting, Li, Jinxiu, Huang, Xingxu, Cheng, Bin, Zhao, Jianping, Xu, Yongjian, Mo, Bi-Wen, Wang, Cong-Yi, Zhang, Huilan
Published in Cell death and differentiation (01.04.2021)
Published in Cell death and differentiation (01.04.2021)
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A Cas-embedding strategy for minimizing off-target effects of DNA base editors
Liu, Yajing, Zhou, Changyang, Huang, Shisheng, Dang, Lu, Wei, Yu, He, Jun, Zhou, Yingsi, Mao, Shaoshuai, Tao, Wanyu, Zhang, Yu, Yang, Hui, Huang, Xingxu, Chi, Tian
Published in Nature communications (27.11.2020)
Published in Nature communications (27.11.2020)
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Efficient generation of mouse models with the prime editing system
Liu, Yao, Li, Xiangyang, He, Siting, Huang, Shuhong, Li, Chao, Chen, Yulin, Liu, Zhen, Huang, Xingxu, Wang, Xiaolong
Published in Cell discovery (28.04.2020)
Published in Cell discovery (28.04.2020)
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Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
Wei, Jun, Marisetty, Anantha, Schrand, Brett, Gabrusiewicz, Konrad, Hashimoto, Yuuri, Ott, Martina, Grami, Zacharia, Kong, Ling-Yuan, Ling, Xiaoyang, Caruso, Hillary, Zhou, Shouhao, Wang, Y Alan, Fuller, Gregory N, Huse, Jason, Gilboa, Eli, Kang, Nannan, Huang, Xingxu, Verhaak, Roel, Li, Shulin, Heimberger, Amy B
Published in The Journal of clinical investigation (01.01.2019)
Published in The Journal of clinical investigation (01.01.2019)
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Off-target mutations are rare in Cas9-modified mice
Iyer, Vivek, Shen, Bin, Zhang, Wensheng, Hodgkins, Alex, Keane, Thomas, Huang, Xingxu, Skarnes, William C
Published in Nature methods (01.06.2015)
Published in Nature methods (01.06.2015)
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Programming and Inheritance of Parental DNA Methylomes in Mammals
Wang, Lu, Zhang, Jun, Duan, Jialei, Gao, Xinxing, Zhu, Wei, Lu, Xingyu, Yang, Lu, Zhang, Jing, Li, Guoqiang, Ci, Weimin, Li, Wei, Zhou, Qi, Aluru, Neel, Tang, Fuchou, He, Chuan, Huang, Xingxu, Liu, Jiang
Published in Cell (08.05.2014)
Published in Cell (08.05.2014)
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Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation
Yin, Yafei, Yan, Pixi, Lu, Jinlong, Song, Guang, Zhu, Yangyang, Li, Zhaohui, Zhao, Yi, Shen, Bin, Huang, Xingxu, Zhu, Heng, Orkin, Stuart H., Shen, Xiaohua
Published in Cell stem cell (07.05.2015)
Published in Cell stem cell (07.05.2015)
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Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
Liu, Zhen, Lu, Zongyang, Yang, Guang, Huang, Shisheng, Li, Guanglei, Feng, Songjie, Liu, Yajing, Li, Jianan, Yu, Wenxia, Zhang, Yu, Chen, Jia, Sun, Qiang, Huang, Xingxu
Published in Nature communications (14.06.2018)
Published in Nature communications (14.06.2018)
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Generating rats with conditional alleles using CRISPR/Cas9
Ma, Yuanwu, Zhang, Xu, Shen, Bin, Lu, Yingdong, Chen, Wei, Ma, Jing, Bai, Lin, Huang, Xingxu, Zhang, Lianfeng
Published in Cell research (01.01.2014)
Published in Cell research (01.01.2014)
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Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors
Wang, Yafeng, Zhang, Guiquan, Meng, Qingzhou, Huang, Shisheng, Guo, Panpan, Leng, Qibin, Sun, Lingyun, Liu, Geng, Huang, Xingxu, Liu, Jianghuai
Published in Nature communications (18.03.2022)
Published in Nature communications (18.03.2022)
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High-resolution annotation of the mouse preimplantation embryo transcriptome using long-read sequencing
Qiao, Yunbo, Ren, Chao, Huang, Shisheng, Yuan, Jie, Liu, Xingchen, Fan, Jiao, Lin, Jianxiang, Wu, Susu, Chen, Qiuzhen, Bo, Xiaochen, Li, Xiangyang, Huang, Xingxu, Liu, Zhen, Shu, Wenjie
Published in Nature communications (27.05.2020)
Published in Nature communications (27.05.2020)
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