Pan-Inhibition of Protein Disulfide Isomerase Caused Cell Death through Disrupting Cellular Proteostasis in Pancreatic Ductal Adenocarcinoma Cells
Hung, Ching-Sheng, Lee, Kun-Lin, Huang, Wei-Jan, Su, Fang-He, Liang, Yu-Chih
Published in International journal of molecular sciences (01.11.2023)
Published in International journal of molecular sciences (01.11.2023)
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Hispidulin attenuates the social withdrawal in isolated disrupted‐in‐schizophrenia‐1 mutant and chronic phencyclidine‐treated mice
Mouri, Akihiro, Lee, Hsin‐Jung, Mamiya, Takayoshi, Aoyama, Yuki, Matsumoto, Yurie, Kubota, Hisayoshi, Huang, Wei‐Jan, Chiou, Lih‐Chu, Nabeshima, Toshitaka
Published in British journal of pharmacology (01.07.2020)
Published in British journal of pharmacology (01.07.2020)
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An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors
Lin, Tony Eight, Yen, Dyan, HuangFu, Wei‐Chun, Wu, Yi‐Wen, Hsu, Jui‐Yi, Yen, Shih‐Chung, Sung, Tzu‐Ying, Hsieh, Jui‐Hua, Pan, Shiow‐Lin, Yang, Chia‐Ron, Huang, Wei‐Jan, Hsu, Kai‐Cheng
Published in Protein science (01.06.2024)
Published in Protein science (01.06.2024)
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Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach
Hsu, Kai-Cheng, Liu, Chang-Yi, Lin, Tony Eight, Hsieh, Jui-Hua, Sung, Tzu-Ying, Tseng, Hui-Ju, Yang, Jinn-Moon, Huang, Wei-Jan
Published in Scientific reports (12.06.2017)
Published in Scientific reports (12.06.2017)
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HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation
Qi, Jing, Singh, Sandeep, Hua, Wei-Kai, Cai, Qi, Chao, Shi-Wei, Li, Ling, Liu, Hongjun, Ho, Yinwei, McDonald, Tinisha, Lin, Allen, Marcucci, Guido, Bhatia, Ravi, Huang, Wei-Jan, Chang, Chung-I, Kuo, Ya-Huei
Published in Cell stem cell (05.11.2015)
Published in Cell stem cell (05.11.2015)
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Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo
Chiu, Hui-Wen, Yeh, Ya-Ling, Wang, Yi-Ching, Huang, Wei-Jan, Chen, Yi-An, Chiou, Yi-Shiou, Ho, Sheng-Yow, Lin, Pinpin, Wang, Ying-Jan
Published in PloS one (10.10.2013)
Published in PloS one (10.10.2013)
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The study of a novel CDK8 inhibitor E966-0530–45418 that inhibits prostate cancer metastasis in vitro and in vivo
Ho, Tai-Yuan, Sung, Ting-Yi, Pan, Shiow-Lin, Huang, Wei-Jan, Hsu, Kai-Cheng, Hsu, Jui-Yi, Lin, Tony Eight, Hsu, Chia-Ming, Yang, Chia-Ron
Published in Biomedicine & pharmacotherapy (01.06.2023)
Published in Biomedicine & pharmacotherapy (01.06.2023)
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Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats
Lin, Tzu-Yu, Huang, Wei-Jan, Wu, Chia-Chan, Lu, Cheng-Wei, Wang, Su-Jane
Published in PloS one (10.02.2014)
Published in PloS one (10.02.2014)
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Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities
Chu, Jung-Chun, Tseng, Hui-Ju, Lee, Sung-Bau, Hsu, Kai-Cheng, Hsin, Ling-Wei, Liang, Ru-Hao, Lin, Tony Eight, Gao, Nain-Chu, Chen, Liang-Chieh, Lu, Wan-Hsun, Wang, Andrew H.-J, Huang, Wei-Jan
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2023)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2023)
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A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer
Wu, Yuan-Hua, Hong, Chi-Wei, Wang, Yi-Ching, Huang, Wei-Jan, Yeh, Ya-Ling, Wang, Bour-Jr, Wang, Ying-Jan, Chiu, Hui-Wen
Published in Cancer letters (01.08.2017)
Published in Cancer letters (01.08.2017)
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A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress
Wu, Liang-Huan, Cheng, Yu-Wen, Lin, Fan-Li, Hsu, Kai-Cheng, Wang, Mong-Heng, Yen, Jing-Lun, Wang, Tsung-Jen, Lin, Tony Eight, Liu, Yi-Chien, Huang, Wei-Jan, Hsiao, George
Published in Biomedicine & pharmacotherapy (01.05.2024)
Published in Biomedicine & pharmacotherapy (01.05.2024)
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HDAC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-Induced Mouse Model of Neuroinflammation and Microglial Activation
Lin, Fan-Li, Yen, Jing-Lun, Kuo, Yu-Cheng, Kang, Jaw-Jou, Cheng, Yu-Wen, Huang, Wei-Jan, Hsiao, George
Published in International journal of molecular sciences (18.01.2019)
Published in International journal of molecular sciences (18.01.2019)
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Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors
Hsu, Jui-Yi, Hsu, Kai-Cheng, Sun, Ching, Chou, Ching-Hsuan, Lin, Tony Eight, Sung, Tzu-Ying, Tseng, Hui-Ju, Yen, Shih-Chung, Yang, Chia-Ron, Huang, Wei-Jan
Published in Biomedicine & pharmacotherapy (01.03.2023)
Published in Biomedicine & pharmacotherapy (01.03.2023)
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Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment
Lin, Tony Eight, Yang, Chia-Ron, Chou, Ching-Hsuan, Hsu, Jui-Yi, Chao, Min-Wu, Sung, Tzu-Ying, Hsieh, Jui-Hua, Huang, Wei-Jan, Hsu, Kai-Cheng
Published in Biomedicine & pharmacotherapy (01.02.2022)
Published in Biomedicine & pharmacotherapy (01.02.2022)
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Journal Article
Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative
Chen, Liang-Chieh, Hsu, Kai-Cheng, Chiou, Lih-Chu, Tseng, Hui-Ju, Huang, Wei-Jan
Published in Molecules (Basel, Switzerland) (04.11.2017)
Published in Molecules (Basel, Switzerland) (04.11.2017)
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A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall‐cell lung cancer
Shieh, Jiunn‐Min, Tang, Yen‐An, Hu, Fu‐Han, Huang, Wei‐Jan, Wang, Ying‐Jan, Jen, Jayu, Liao, Sheng‐You, Lu, Ying‐Hung, Yeh, Ya‐Ling, Wang, Tseng‐Wei, Lin, Pinpin, Wang, Yi‐Ching
Published in International journal of cancer (15.05.2017)
Published in International journal of cancer (15.05.2017)
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Cerebellar α6‐subunit‐containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders
Chiou, Lih‐Chu, Lee, Hsin‐Jung, Ernst, Margot, Huang, Wei‐Jan, Chou, Jui‐Feng, Chen, Hon‐Lie, Mouri, Akihiro, Chen, Liang‐Chieh, Treven, Marco, Mamiya, Takayoshi, Fan, Pi‐Chuan, Knutson, Daniel E, Witzigmann, Chris, Cook, James, Sieghart, Werner, Nabeshima, Toshitaka
Published in British journal of pharmacology (01.06.2018)
Published in British journal of pharmacology (01.06.2018)
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