An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway
Guo, Deliang, Reinitz, Felicia, Youssef, Mary, Hong, Cynthia, Nathanson, David, Akhavan, David, Kuga, Daisuke, Amzajerdi, Ali Nael, Soto, Horacio, Zhu, Shaojun, Babic, Ivan, Tanaka, Kazuhiro, Dang, Julie, Iwanami, Akio, Gini, Beatrice, Dejesus, Jason, Lisiero, Dominique D, Huang, Tiffany T, Prins, Robert M, Wen, Patrick Y, Robins, H Ian, Prados, Michael D, Deangelis, Lisa M, Mellinghoff, Ingo K, Mehta, Minesh P, James, C David, Chakravarti, Arnab, Cloughesy, Timothy F, Tontonoz, Peter, Mischel, Paul S
Published in Cancer discovery (01.10.2011)
Published in Cancer discovery (01.10.2011)
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EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
Guo, Deliang, Prins, Robert M, Dang, Julie, Kuga, Daisuke, Iwanami, Akio, Soto, Horacio, Lin, Kelly Y, Huang, Tiffany T, Akhavan, David, Hock, M Benjamin, Zhu, Shaojun, Kofman, Ava A, Bensinger, Steve J, Yong, William H, Vinters, Harry V, Horvath, Steve, Watson, Andrew D, Kuhn, John G, Robins, H Ian, Mehta, Minesh P, Wen, Patrick Y, DeAngelis, Lisa M, Prados, Michael D, Mellinghoff, Ingo K, Cloughesy, Timothy F, Mischel, Paul S
Published in Science signaling (15.12.2009)
Published in Science signaling (15.12.2009)
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Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity
Hiraoka, Kei, Inagaki, Akihito, Kato, Yuki, Huang, Tiffany T, Mitchell, Leah A, Kamijima, Shuichi, Takahashi, Masamichi, Matsumoto, Hiroshi, Hacke, Katrin, Kruse, Carol A, Ostertag, Derek, Robbins, Joan M, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
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Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model
Huang, Tiffany T, Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M, Espinoza, Fernando Lopez, Martin, Bryan, Ibañez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Pertschuk, Daniel, Jolly, Douglas J, Robbins, Joan M
Published in Human gene therapy (01.02.2015)
Published in Human gene therapy (01.02.2015)
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Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
LU, Kan V, SHAOJUN ZHU, LEE, Yohan, ZUGEN CHEN, CALDWELL, Jeremy S, YONGMIN XIE, LOO, Joseph A, SELIGSON, David, CHAKRAVARI, Arnab, LEE, Francis Y, WEINMANN, Roberto, CLOUGHESY, Timothy F, CVRLJEVIC, Anna, NELSON, Stanley F, BERGERS, Gabriele, GRAEBER, Thomas, FURNARI, Frank B, JAMES, C. David, CAVENEE, Webster K, JOHNS, Terrance G, MISCHEL, Paul S, HUANG, Tiffany T, SARKARIA, Shawn, AHKAVAN, David, DANG, Julie, DINCA, Eduard B, PLAISIER, Seema B, ODERBERG, Isaac
Published in Cancer research (Chicago, Ill.) (01.09.2009)
Published in Cancer research (Chicago, Ill.) (01.09.2009)
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Targeted Therapy for Malignant Glioma Patients: Lessons Learned and the Road Ahead
Huang, Tiffany T., Sarkaria, Shawn M., Cloughesy, Timothy F., Mischel, Paul S.
Published in Neurotherapeutics (01.07.2009)
Published in Neurotherapeutics (01.07.2009)
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Mechanical behaviour of porous hydroxyapatite
He, Li-Hong, Standard, Owen C., Huang, Tiffany T.Y., Latella, Bruno A., Swain, Michael V.
Published in Acta biomaterialia (01.05.2008)
Published in Acta biomaterialia (01.05.2008)
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Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models
Yagiz, Kader, Huang, Tiffany T, Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
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Abstract 1413: Treatment of mouse liver and brain colon cancer metastases with Toca 511 and 5-fluorocytosine for intratumoral production of 5-fluorouracil leads to increased survival, induction of antitumor immune responses, and reduction of MDSC
Rodriguez-Aguirre, Maria, Yagiz, Kader, Lopez Espinoza, Fernando, Mendoza, Daniel, Huang, Tiffany T., Ibanez, Carlos, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Characterisation of enamel white spot lesions using X-ray micro-tomography
Huang, Tiffany T.Y, Jones, Allan S, He, Li Hong, Darendeliler, M. Ali, Swain, Michael V
Published in Journal of dentistry (01.09.2007)
Published in Journal of dentistry (01.09.2007)
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Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells
Wei, Bo, Su, Thomas T., Dalwadi, Harnisha, Stephan, Robert P., Fujiwara, Daisuke, Huang, Tiffany T., Brewer, Sarah, Chen, Lindy, Arditi, Moshe, Borneman, James, Rawlings, David J., Braun, Jonathan
Published in European journal of immunology (01.12.2008)
Published in European journal of immunology (01.12.2008)
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Villous B Cells of the Small Intestine Are Specialized for Invariant NK T Cell Dependence
Velazquez, Peter, Wei, Bo, McPherson, Michael, Mendoza, Lesley Marie A, Nguyen, Sandra L, Turovskaya, Olga, Kronenberg, Mitchell, Huang, Tiffany T, Schrage, Matthew, Lobato, Lynn N, Fujiwara, Daisuke, Brewer, Sarah, Arditi, Moshe, Cheng, Genhong, Sartor, R. Balfour, Newberry, Rodney D, Braun, Jonathan
Published in The Journal of immunology (1950) (01.04.2008)
Published in The Journal of immunology (1950) (01.04.2008)
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Additive therapeutic effect of a non-lytic retroviral replicating vector (Toca 511) and 5-fluorocytosine in combination with lomustine in experimental glioma models
Robbins, Joan M., Huang, Tiffany T., Yagiz, Kader, Lopez Espinoza, Fernando, Martin, Bryan, Rodriguez-Aguirre, Maria, Ibanez, Carlos E., Gruber, Harry E., Jolly, Douglas J.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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AT-29INTRAVENOUS ADMINISTRATION OF TOCA 511 IN PATIENTS WITH RECURRENT GLIOBLASTOMA
Kalkanis, Steven, Jolly, Doug J., Pertschuk, Dan, Ostertag, Derek, Robbins, Joan M., Huang, Tiffany T., Gruber, Harry, Mikkelsen, Tom
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2014)
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2014)
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Journal Article
531. Intravenous Delivery of Toca 511 Gene Therapy in Combination with 5-Fluorocytosine for Intratumoral Production of 5-Fluorouracil in a Colon Cancer Metastasis Model
Yagiz, Kader, Rodriguez-Aguirre, Maria E., Espinoza, Fernando L., Martin, Bryan, Huang, Tiffany T., Ibanez, Carlos, Ostertag, Derek, Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Molecular therapy (01.05.2015)
Published in Molecular therapy (01.05.2015)
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Abstract 708: Toca 511 gene therapy in combination with 5-fluorocytosine for intratumoral production of 5-fluorouracil in a colon cancer metastasis model
Rodriguez-Aguirre, Maria E., Espinoza, Fernando Lopez, Martin, Bryan, Yadiz, Kader, Huang, Tiffany T., Ibanez, Carlos E., Ostertag, Derek G., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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AT-29 INTRAVENOUS ADMINISTRATION OF TOCA 511 IN PATIENTS WITH RECURRENT GLIOBLASTOMA
Kalkanis, S., Jolly, D. J., Pertschuk, D., Ostertag, D., Robbins, J. M., Huang, T. T., Gruber, H., Mikkelsen, T.
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2014)
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2014)
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AT-02INTRATUMORAL DELIVERY OF THE RETROVIRAL REPLICATING VECTOR (RRV) TOCA 511 IN SUBJECTS WITH RECURRENT HIGH GRADE GLIOMA: INTERIM REPORT OF PHASE 1 STUDY (NCT 01156584)
Aghi, Manish, Vogelbaum, Michael A., Kesari, Santosh, Chen, Clark C., Liau, Linda M., Piccioni, David, Portnow, Jana, Chang, Susan, Robbins, Joan M., Boyce, Tammy, Huang, Tiffany T., Pertschuk, Dan, Ostertag, Derek, Cloughesy, Timothy F.
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2014)
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2014)
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