Targeted anti-mitotic therapies: can we improve on tubulin agents?
Jackson, Jeffrey R, Patrick, Denis R, Dar, Mohammed M, Huang, Pearl S
Published in Nature reviews. Cancer (01.02.2007)
Published in Nature reviews. Cancer (01.02.2007)
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EMT is the dominant program in human colon cancer
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Published in BMC genomics (20.01.2011)
Published in BMC genomics (20.01.2011)
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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
RHODES, Nelson, HEERDING, Dirk A, KAHANA, Jason A, GESKE, Robert S, KIEYMENOVA, Elena V, CHOUDHRY, Anthony E, ZHIHONG LAI, LEBER, Jack D, MINTHORN, Elisabeth A, STRUM, Susan L, WOOD, Edgar R, HUANG, Pearl S, DUCKETT, Derek R, COPELAND, Robert A, KUMAR, Rakesh, EBERWEIN, Derek J, KNICK, Victoria B, LANSING, Timothy J, MCCONNELL, Randy T, GILMER, Tona M, ZHANG, Shu-Yun, ROBELL, Kimberly
Published in Cancer research (Chicago, Ill.) (01.04.2008)
Published in Cancer research (Chicago, Ill.) (01.04.2008)
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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E
Wood, Kenneth W, Lad, Latesh, Luo, Lusong, Qian, Xiangping, Knight, Steven D, Nevins, Neysa, Brejc, Katjusa, Sutton, David, Gilmartin, Aidan G, Chua, Penelope R, Desai, Radhika, Schauer, Stephen P, McNulty, Dean E, Annan, Roland S, Belmont, Lisa D, Garcia, Carlos, Lee, Yan, Diamond, Melody A, Faucette, Leo F, Giardiniere, Michele, Zhang, ShuYun, Sun, Chiu-Mei, Vidal, Justin D, Lichtsteiner, Serge, Cornwell, William D, Greshock, Joel D, Wooster, Richard F, Finer, Jeffrey T, Copeland, Robert A, Huang, Pearl S, Morgans, David J. Jr, Dhanak, Dashyant, Bergnes, Gustave, Sakowicz, Roman, Jackson, Jeffrey R
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.2010)
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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
KING, Alastair J, PATRICK, Denis R, HUGGER, Erin, LIFU WANG, KARRETH, Florian, LOUGHEED, Julie C, LEE, Jae, CHAU, David, STOUT, Thomas J, MAY, Earl W, ROMINGER, Cynthia M, SCHABER, Michael D, BATORSKY, Roberta S, LUSONG LUO, LAKDAWALA, Ami S, ADAMS, Jerry L, CONTRACTOR, Rooja G, SMALLEY, Keiran S. M, HERLYN, Meenhard, MORRISSEY, Michael M, TUVESON, David A, HUANG, Pearl S, HO, Maureen L, DO, Hieu T, SHU YUN ZHANG, KUMAR, Rakesh, RUSNAK, David W, TAKLE, Andrew K, WILSON, David M
Published in Cancer research (Chicago, Ill.) (01.12.2006)
Published in Cancer research (Chicago, Ill.) (01.12.2006)
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ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism
Luo, Lusong, Parrish, Cynthia A, Nevins, Neysa, McNulty, Dean E, Chaudhari, Amita M, Carson, Jeffery D, Sudakin, Valery, Shaw, Antony N, Lehr, Ruth, Zhao, Huizhen, Sweitzer, Sharon, Lad, Latesh, Wood, Kenneth W, Sakowicz, Roman, Annan, Roland S, Huang, Pearl S, Jackson, Jeffrey R, Dhanak, Dashyant, Copeland, Robert A, Auger, Kurt R
Published in Nature chemical biology (01.11.2007)
Published in Nature chemical biology (01.11.2007)
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Mechanism of Inhibition of Human KSP by Monastrol: Insights from Kinetic Analysis and the Effect of Ionic Strength on KSP Inhibition
Luo, Lusong, Carson, Jeffrey D, Dhanak, Dashyant, Jackson, Jeffrey R, Huang, Pearl S, Lee, Yan, Sakowicz, Roman, Copeland, Robert A
Published in Biochemistry (Easton) (07.12.2004)
Published in Biochemistry (Easton) (07.12.2004)
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Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator
Luo, Lusong, Carson, Jeffrey D, Molnar, Kathleen S, Tuske, Steven J, Coales, Stephen J, Hamuro, Yoshitomo, Sung, Chiu-mei, Sudakin, Valery, Auger, Kurt R, Dhanak, Dashyant, Jackson, Jeffrey R, Huang, Pearl S, Tummino, Peter J, Copeland, Robert A
Published in Journal of the American Chemical Society (18.06.2008)
Published in Journal of the American Chemical Society (18.06.2008)
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Can phenotypic pathway signatures improve the prediction of response to PI3K pathway inhibitors?
Watters, James W, Huang, Pearl S
Published in Drug discovery today. Therapeutic strategies (01.06.2009)
Published in Drug discovery today. Therapeutic strategies (01.06.2009)
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Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
Defeo-Jones, Deborah, Huang, Pearl S, Jones, Raymond E, Haskell, Kathleen M, Vuocolo, Gerald A, Hanobik, Michelle G, Huber, Hans E, Oliff, Alien
Published in Nature (London) (18.07.1991)
Published in Nature (London) (18.07.1991)
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Leading the way to the next generation of anti-mitotics
Wood, Kenneth W, Jackson, Jeffrey R, Morgans, David J, Elliott, John D, Sabry, James H, Huang, Pearl S
Published in Nature (London) (17.04.2003)
Published in Nature (London) (17.04.2003)
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An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-γ1
Huang, Pearl S., Davis, Lenora, Huber, Hans, Goodhart, Paula J., Wegrzyn, Ron E., Oliff, Allen, Heimbrook, David C.
Published in FEBS letters (30.01.1995)
Published in FEBS letters (30.01.1995)
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Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein
HUANG, P. S, PATRICK, D. R, EDWARDS, G, GOODHARDT, P. J, HUBER, H. E, MILES, L, GARSKY, V. M, OLIFF, A, HEIMBROOK, D. C
Published in Molecular and Cellular Biology (01.02.1993)
Published in Molecular and Cellular Biology (01.02.1993)
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