Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination
Huang, Kai-Lieh, Jee, David, Stein, Chad B., Elrod, Nathan D., Henriques, Telmo, Mascibroda, Lauren G., Baillat, David, Russell, William K., Adelman, Karen, Wagner, Eric J.
Published in Molecular cell (15.10.2020)
Published in Molecular cell (15.10.2020)
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Journal Article
An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Li, Lei, Huang, Kai-Lieh, Gao, Yipeng, Cui, Ya, Wang, Gao, Elrod, Nathan D., Li, Yumei, Chen, Yiling Elaine, Ji, Ping, Peng, Fanglue, Russell, William K., Wagner, Eric J., Li, Wei
Published in Nature genetics (01.07.2021)
Published in Nature genetics (01.07.2021)
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Journal Article
The Integrator complex cleaves nascent mRNAs to attenuate transcription
Tatomer, Deirdre C, Elrod, Nathan D, Liang, Dongming, Xiao, Mei-Sheng, Jiang, Jeffrey Z, Jonathan, Michael, Huang, Kai-Lieh, Wagner, Eric J, Cherry, Sara, Wilusz, Jeremy E
Published in Genes & development (01.11.2019)
Published in Genes & development (01.11.2019)
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Journal Article
A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection
Ciesla, Jessica, Huang, Kai-Lieh, Wagner, Eric J, Munger, Joshua
Published in PLoS pathogens (01.05.2024)
Published in PLoS pathogens (01.05.2024)
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Journal Article
Inositol hexakisphosphate is required for Integrator function
Lin, Min-Han, Jensen, Madeline K., Elrod, Nathan D., Huang, Kai-Lieh, Welle, Kevin A., Wagner, Eric J., Tong, Liang
Published in Nature communications (30.09.2022)
Published in Nature communications (30.09.2022)
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Journal Article
Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies
Lahat, Guy, Zhu, Quan-Sheng, Huang, Kai-Lieh, Wang, Suizhao, Bolshakov, Svetlana, Liu, Jeffery, Torres, Keila, Langley, Robert R, Lazar, Alexander J, Hung, Mien Chie, Lev, Dina
Published in PloS one (16.04.2010)
Published in PloS one (16.04.2010)
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Journal Article
Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine Leiomyosarcoma
BREWER SAVANNAH, Kari J, DEMICCO, Elizabeth G, POLLOCK, Raphael E, CREIGHTON, Chad J, ANDERSON, Matthew L, LEV, Dina, LUSBY, Kristelle, GHADIM, Markus PH, BELOUSOV, Roman, YOUNG, Eric, YIQUN ZHANG, HUANG, Kai-Lieh, LAZAR, Alexander J, HUNT, Kelly K
Published in Clinical cancer research (01.09.2012)
Published in Clinical cancer research (01.09.2012)
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Journal Article
Nongenomic Androgen Activation of Phosphatidylinositol 3‐Kinase/Akt Signaling Pathway in MC3T3‐E1 Osteoblasts
Kang, Hong‐Yo, Cho, Chung‐Lung, Huang, Kai‐Lieh, Wang, Jyh‐Chwan, Hu, Yueh‐Chiang, Lin, Hui‐Kuan, Chang, Chawnshang, Huang, Ko‐En
Published in Journal of bone and mineral research (01.07.2004)
Published in Journal of bone and mineral research (01.07.2004)
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Journal Article
Expression of 'drugable' tyrosine kinase receptors in malignant peripheral nerve sheath tumour: potential molecular therapeutic targets for a chemoresistant cancer
Torres, Keila E., Liu, Jun, Young, Eric, Huang, Kai-Lieh, Ghadimi, Markus, Lusby, Kristelle, Lazar, Alexander J., Lev, Dina
Published in Histopathology (01.07.2011)
Published in Histopathology (01.07.2011)
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Journal Article
Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation
Chen, Chyi-Ying A, Strouz, Krista, Huang, Kai-Lieh, Shyu, Ann-Bin
Published in RNA (Cambridge) (01.09.2020)
Published in RNA (Cambridge) (01.09.2020)
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Journal Article
Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module
Albrecht, Todd R, Shevtsov, Sergey P, Wu, Yixuan, Mascibroda, Lauren G, Peart, Natoya J, Huang, Kai-Lieh, Sawyer, Iain A, Tong, Liang, Dundr, Miroslav, Wagner, Eric J
Published in Nucleic acids research (04.05.2018)
Published in Nucleic acids research (04.05.2018)
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Journal Article
NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1
Jonnakuti, Venkata Soumith, Ji, Ping, Gao, Yipeng, Lin, Ai, Chu, Yuan, Elrod, Nathan, Huang, Kai-Lieh, Li, Wei, Yalamanchili, Hari Krishna, Wagner, Eric J.
Published in Journal of neuro-oncology (01.07.2023)
Published in Journal of neuro-oncology (01.07.2023)
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Journal Article
Src Family Kinases Mediate Betel Quid-Induced Oral Cancer Cell Motility and Could Be a Biomarker for Early Invasion in Oral Squamous Cell Carcinoma
Chen, Jeff Yi-Fu, Hung, Chih-Chang, Huang, Kai-Lieh, Chen, Yi-Ting, Liu, Shyun-Yeu, Chiang, Wei-Fan, Chen, Hau-Ren, Yen, Ching-Yu, Wu, Yu-Jen, Ko, Jenq-Yuh, Jou, Yuh-Shan
Published in Neoplasia (New York, N.Y.) (01.12.2008)
Published in Neoplasia (New York, N.Y.) (01.12.2008)
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Journal Article
INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex
Mascibroda, Lauren G., Shboul, Mohammad, Elrod, Nathan D., Colleaux, Laurence, Hamamy, Hanan, Huang, Kai-Lieh, Peart, Natoya, Singh, Moirangthem Kiran, Lee, Hane, Merriman, Barry, Jodoin, Jeanne N., Sitaram, Poojitha, Lee, Laura A., Fathalla, Raja, Al-Rawashdeh, Baeth, Ababneh, Osama, El-Khateeb, Mohammad, Escande-Beillard, Nathalie, Nelson, Stanley F., Wu, Yixuan, Tong, Liang, Kenney, Linda J., Roy, Sudipto, Russell, William K., Amiel, Jeanne, Reversade, Bruno, Wagner, Eric J.
Published in Nature communications (13.10.2022)
Published in Nature communications (13.10.2022)
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Journal Article
Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate
Huang, Kai-Lieh, Chadee, Amanda B, Chen, Chyi-Ying A, Zhang, Yueqiang, Shyu, Ann-Bin
Published in RNA (Cambridge) (01.03.2013)
Published in RNA (Cambridge) (01.03.2013)
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Journal Article
Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites
de Prisco, Nicola, Ford, Caitlin, Elrod, Nathan D., Lee, Winston, Tang, Lauren C., Huang, Kai-Lieh, Lin, Ai, Ji, Ping, Jonnakuti, Venkata S., Boyle, Lia, Cabaj, Maximilian, Botta, Salvatore, Õunap, Katrin, Reinson, Karit, Wojcik, Monica H., Rosenfeld, Jill A., Bi, Weimin, Tveten, Kristian, Prescott, Trine, Gerstner, Thorsten, Schroeder, Audrey, Fong, Chin-To, George-Abraham, Jaya K., Buchanan, Catherine A., Hanson-Khan, Andrea, Bernstein, Jonathan A., Nella, Aikaterini A., Chung, Wendy K., Brandt, Vicky, Jovanovic, Marko, Targoff, Kimara L., Yalamanchili, Hari Krishna, Wagner, Eric J., Gennarino, Vincenzo A.
Published in Science advances (17.02.2023)
Published in Science advances (17.02.2023)
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Journal Article
Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor
Kivlin, Christine M., Watson, Kelsey L., Al Sannaa, Ghadah A., Belousov, Roman, Ingram, Davis R., Huang, Kai-Lieh, May, Caitlin D., Bolshakov, Svetlana, Landers, Sharon M., Kalam, Azad Abul, Slopis, John M., McCutcheon, Ian E., Pollock, Raphael E., Lev, Dina, Lazar, Alexander J., Torres, Keila E.
Published in Cancer biology & therapy (01.02.2016)
Published in Cancer biology & therapy (01.02.2016)
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Journal Article
Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function
Lin, Min-Han, Jensen, Madeline K., Elrod, Nathan D., Chu, Hsu-Feng, Haseley, MaryClaire, Beam, Alissa C., Huang, Kai-Lieh, Chiang, Wesley, Russell, William K., Williams, Kelsey, Pröschel, Christoph, Wagner, Eric J., Tong, Liang
Published in Molecular cell (08.08.2024)
Published in Molecular cell (08.08.2024)
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