Short‐duration treatment with elbasvir/grazoprevir and sofosbuvir for hepatitis C: A randomized trial
Lawitz, Eric, Poordad, Fred, Gutierrez, Julio A., Wells, Jennifer T., Landaverde, Carmen E., Evans, Barbara, Howe, Anita, Huang, Hsueh‐Cheng, Li, Jerry Jing, Hwang, Peggy, Dutko, Frank J., Robertson, Michael, Wahl, Janice, Barr, Eliav, Haber, Barbara
Published in Hepatology (Baltimore, Md.) (01.02.2017)
Published in Hepatology (Baltimore, Md.) (01.02.2017)
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Grazoprevir, ruzasvir, and uprifosbuvir for hepatitis C virus after NS5A treatment failure
Wyles, David, Wedemeyer, Heiner, Ben‐Ari, Ziv, Gane, Edward J., Hansen, Jesper Bach, Jacobson, Ira M., Laursen, Alex L., Luetkemeyer, Annie, Nahass, Ronald, Pianko, Stephen, Zeuzem, Stefan, Jumes, Patricia, Huang, Hsueh‐Cheng, Butterton, Joan, Robertson, Michael, Wahl, Janice, Barr, Eliav, Joeng, Hee‐Koung, Martin, Elizabeth, Serfaty, Lawrence
Published in Hepatology (Baltimore, Md.) (01.12.2017)
Published in Hepatology (Baltimore, Md.) (01.12.2017)
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Cyclic-Disulfide-Based Prodrugs for Cytosol-Specific Drug Delivery
Butora, Gabor, Qi, Ning, Fu, Wenlang, Nguyen, Truyen, Huang, Hsueh-Cheng, Davies, Ian W.
Published in Angewandte Chemie International Edition (15.12.2014)
Published in Angewandte Chemie International Edition (15.12.2014)
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Elbasvir-Grazoprevir to Treat Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy: A Randomized Trial
Dore, Gregory J, Altice, Frederick, Litwin, Alain H, Dalgard, Olav, Gane, Edward J, Shibolet, Oren, Luetkemeyer, Anne, Nahass, Ronald, Peng, Cheng-Yuan, Conway, Brian, Grebely, Jason, Howe, Anita Y M, Gendrano, Isaias N, Chen, Erluo, Huang, Hsueh-Cheng, Dutko, Frank J, Nickle, David C, Nguyen, Bach-Yen, Wahl, Janice, Barr, Eliav, Robertson, Michael N, Platt, Heather L
Published in Annals of internal medicine (01.11.2016)
Published in Annals of internal medicine (01.11.2016)
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Novel intramolecular aminohydroxylation toward the syntheses of 2′-amino-2′-ethynyl nucleosides
Huang, Yuhua, Bennett, Frank, Buevich, Alexei, Girijavallabhan, Vinay, Kerekes, Angela D., Huang, Hsueh-Cheng, Tawa, Paul, Bogen, Stephane L., Davies, Ian W.
Published in Tetrahedron letters (25.05.2021)
Published in Tetrahedron letters (25.05.2021)
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Ube3a unsilencer for the potential treatment of Angelman syndrome
Vihma, Hanna, Li, Kelin, Welton-Arndt, Anna, Smith, Audrey L., Bettadapur, Kiran R., Gilmore, Rachel B., Gao, Eric, Cotney, Justin L., Huang, Hsueh-Cheng, Collins, Jon L., Chamberlain, Stormy J., Lee, Hyeong-Min, Aubé, Jeffrey, Philpot, Benjamin D.
Published in Nature communications (08.07.2024)
Published in Nature communications (08.07.2024)
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Concise syntheses and HCV NS5B polymerase inhibition of (2′R)-3 and (2′S)-2′-ethynyluridine-10 and related nucleosides
Bennett, Frank, Buevich, Alexei V., Huang, Hsueh-Cheng, Girijavallabhan, Vinay, Kerekes, Angela D., Huang, Yuhua, Malikzay, Asra, Smith, Elizabeth, Ferrari, Eric, Senior, Mary, Osterman, Rebecca, Wang, Lingyan, Wang, Jun, Pu, Haiyan, Truong, Quang T., Tawa, Paul, Bogen, Stephane L., Davies, Ian W., Weber, Ann E.
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase
Chen, Kevin X, Vibulbhan, Bancha, Yang, Weiying, Sannigrahi, Mousumi, Velazquez, Francisco, Chan, Tin-Yau, Venkatraman, Srikanth, Anilkumar, Gopinadhan N, Zeng, Qingbei, Bennet, Frank, Jiang, Yueheng, Lesburg, Charles A, Duca, Jose, Pinto, Patrick, Gavalas, Stephen, Huang, Yuhua, Wu, Wanli, Selyutin, Oleg, Agrawal, Sony, Feld, Boris, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
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A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors
Chen, Kevin X, Lesburg, Charles A, Vibulbhan, Bancha, Yang, Weiying, Chan, Tin-Yau, Venkatraman, Srikanth, Velazquez, Francisco, Zeng, Qingbei, Bennett, Frank, Anilkumar, Gopinadhan N, Duca, Jose, Jiang, Yueheng, Pinto, Patrick, Wang, Li, Huang, Yuhua, Selyutin, Oleg, Gavalas, Stephen, Pu, Haiyan, Agrawal, Sony, Feld, Boris, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics
Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Heimark, Larry, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George
Published in Bioorganic & medicinal chemistry (01.01.2014)
Published in Bioorganic & medicinal chemistry (01.01.2014)
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Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase
Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George
Published in Bioorganic & medicinal chemistry (01.04.2013)
Published in Bioorganic & medicinal chemistry (01.04.2013)
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Safety and efficacy of an 8-week regimen of grazoprevir plus ruzasvir plus uprifosbuvir compared with grazoprevir plus elbasvir plus uprifosbuvir in participants without cirrhosis infected with hepatitis C virus genotypes 1, 2, or 3 (C-CREST-1 and C-CREST-2, part A): two randomised, phase 2, open-label trials
Gane, Edward J, Pianko, Stephen, Roberts, Stuart K, Thompson, Alexander J, Zeuzem, Stefan, Zuckerman, Eli, Ben-Ari, Ziv, Foster, Graham R, Agarwal, Kosh, Laursen, Alex L, Gerstoft, Jan, Gao, Wei, Huang, Hsueh-Cheng, Fitzgerald, Brian, Fernsler, Doreen, Li, Jerry J, Grandhi, Anjana, Liu, Hong, Su, Feng-Hsiu, Wan, Shuyan, Zeng, Zhen, Chen, Huei-Ling, Dutko, Frank J, Nguyen, Bach-Yen T, Wahl, Janice, Robertson, Michael N, Barr, Eliav, Yeh, Wendy W, Plank, Rebeca M, Butterton, Joan R, Esteban, Rafael
Published in The lancet. Gastroenterology & hepatology (01.11.2017)
Published in The lancet. Gastroenterology & hepatology (01.11.2017)
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Discovery of an irreversible HCV NS5B polymerase inhibitor
Zeng, Qingbei, Nair, Anilkumar G., Rosenblum, Stuart B., Huang, Hsueh-Cheng, Lesburg, Charles A., Jiang, Yueheng, Selyutin, Oleg, Chan, Tin-Yau, Bennett, Frank, Chen, Kevin X., Venkatraman, Srikanth, Sannigrahi, Mousumi, Velazquez, Francisco, Duca, Jose S., Gavalas, Stephen, Huang, Yuhua, Pu, Haiyan, Wang, Li, Pinto, Patrick, Vibulbhan, Bancha, Agrawal, Sony, Ferrari, Eric, Jiang, Chuan-kui, Li, Cheng, Hesk, David, Gesell, Jennifer, Sorota, Steve, Shih, Neng-Yang, Njoroge, F. George, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Safety and efficacy of a fixed-dose combination regimen of grazoprevir, ruzasvir, and uprifosbuvir with or without ribavirin in participants with and without cirrhosis with chronic hepatitis C virus genotype 1, 2, or 3 infection (C-CREST-1 and C-CREST-2, part B): two randomised, phase 2, open-label trials
Lawitz, Eric, Buti, Maria, Vierling, John M, Almasio, Piero L, Bruno, Savino, Ruane, Peter J, Hassanein, Tarek I, Muellhaupt, Beat, Pearlman, Brian, Jancoriene, Ligita, Gao, Wei, Huang, Hsueh-Cheng, Shepherd, Aimee, Tannenbaum, Brynne, Fernsler, Doreen, Li, Jerry J, Grandhi, Anjana, Liu, Hong, Su, Feng-Hsiu, Wan, Shuyan, Dutko, Frank J, Nguyen, Bach-Yen T, Wahl, Janice, Robertson, Michael N, Barr, Eliav, Yeh, Wendy W, Plank, Rebeca M, Butterton, Joan R, Yoshida, Eric M
Published in The lancet. Gastroenterology & hepatology (01.11.2017)
Published in The lancet. Gastroenterology & hepatology (01.11.2017)
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5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
Arasappan, Ashok, Bennett, Frank, Girijavallabhan, Vinay, Huang, Yuhua, Huelgas, Regina, Alvarez, Carmen, Chen, Lei, Gavalas, Stephen, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Journal Article
Novel substituted pyrimidines as HCV replication (replicase) inhibitors
Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Shih, Neng-Yang, Piwinski, John J., Li, Cheng, Feld, Boris, Huang, Hsueh-Cheng, Tong, Xiao, George Njoroge, F., Arasappan, Ashok
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors
Verma, Vishal A., Rossman, Randall, Bennett, Frank, Chen, Lei, Gavalas, Stephen, Girijavallabhan, Vinay, Huang, Yuhua, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Kozlowski, Joseph, MacCoss, Malcolm, Kwong, Cecil D., Bansal, Namita, Kezar, Hollis S., Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George, Arasappan, Ashok
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Journal Article
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors
Girijavallabhan, Vinay M., Alvarez, Carmen, Bennett, Frank, Chen, Lei, Gavalas, Stephen, Huang, Yuhua, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Bansal, Namita, Clark, Jeremy L., Fowler, Anita T., Kezar, Hollis S., Valiyaveettil, Jacob, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George, Arasappan, Ashok
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Journal Article
Cyclic-Disulfide-Based Prodrugs for Cytosol-Specific Drug Delivery
Butora, Gabor, Qi, Ning, Fu, Wenlang, Nguyen, Truyen, Huang, Hsueh-Cheng, Davies, Ian W.
Published in Angewandte Chemie (15.12.2014)
Published in Angewandte Chemie (15.12.2014)
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