Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
Benci, Joseph L., Xu, Bihui, Qiu, Yu, Wu, Tony J., Dada, Hannah, Twyman-Saint Victor, Christina, Cucolo, Lisa, Lee, David S.M., Pauken, Kristen E., Huang, Alexander C., Gangadhar, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Feldman, Michael D., Ishwaran, Hemant, Vonderheide, Robert H., Maity, Amit, Wherry, E. John, Minn, Andy J.
Published in Cell (01.12.2016)
Published in Cell (01.12.2016)
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BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma
Mehnert, Janice M, Mitchell, Tara C, Huang, Alexander C, Aleman, Tomas S, Kim, Benjamin J, Schuchter, Lynn M, Linette, Gerald P, Karakousis, Giorgos C, Mitnick, Sheryl, Giles, Lydia, Carberry, Mary, Frey, Noelle, Kossenkov, Andrew, Groisberg, Roman, Hernandez-Aya, Leonel F, Ansstas, George, Silk, Ann W, Chandra, Sunandana, Sosman, Jeffrey A, Gimotty, Phyllis A, Mick, Rosemarie, Amaravadi, Ravi K
Published in Clinical cancer research (15.03.2022)
Published in Clinical cancer research (15.03.2022)
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Feasibility of monitoring advanced melanoma patients using cell‐free DNA from plasma
Gangadhar, Tara C., Savitch, Samantha L., Yee, Stephanie S., Xu, Wei, Huang, Alexander C., Harmon, Shannon, Lieberman, David B., Soucier, Devon, Fan, Ryan, Black, Taylor A., Morrissette, Jennifer J. D., Salathia, Neeraj, Waters, Jill, Zhang, Shile, Toung, Jonathan, Hummelen, Paul, Fan, Jian‐Bing, Xu, Xiaowei, Amaravadi, Ravi K., Schuchter, Lynn M., Karakousis, Giorgos C., Hwang, Wei‐Ting, Carpenter, Erica L.
Published in Pigment cell and melanoma research (01.01.2018)
Published in Pigment cell and melanoma research (01.01.2018)
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Alpha-Fetoprotein-Producing Lung Hepatoid Adenocarcinoma with Brain Metastasis Treated with S-1
Muroyama, Yuki, Tamiya, Hiroyuki, Tanaka, Goh, Tanaka, Wakae, Huang, Alexander C., Oldridge, Derek A., Matsusaka, Keisuke, Takazawa, Yutaka, Jo, Taisuke, Ushiku, Tetsuo, Nagase, Takahide
Published in Case reports in oncology (23.12.2020)
Published in Case reports in oncology (23.12.2020)
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Dichotomous and stable gamma delta T-cell number and function in healthy individuals
Ou, Lingling, Wang, Huaishan, Liu, Qin, Zhang, Jie, Lu, Hezhe, Luo, Liangping, Shi, Changzheng, Lin, Shaoqiang, Dong, Liyun, Guo, Yeye, Huang, Lili, Zhu, Jinjin, Yin, Xiangfan, Huang, Alexander C, Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi, Zheng, Cathy, Fan, Yi, Guo, Wei, Xu, Xiaowei
Published in Journal for immunotherapy of cancer (01.05.2021)
Published in Journal for immunotherapy of cancer (01.05.2021)
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High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline
Wang, Guanning, Lyudovyk, Olga, Kim, Justin Y., Lin, Ya-Hui, Elhanati, Yuval, Mathew, Divij, Wherry, E. John, Herati, Ramin S., Greenplate, Allison R., Greenbaum, Benjamin, Vardhana, Santosha A., Huang, Alexander C.
Published in STAR protocols (16.06.2023)
Published in STAR protocols (16.06.2023)
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Preclinical platforms to study therapeutic efficacy of human γδ T cells
Ou, Lingling, Wang, Huaishan, Huang, Hui, Zhou, Zhiyan, Lin, Qiang, Guo, Yeye, Mitchell, Tara, Huang, Alexander C., Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi, Guo, Wei, Salvino, Joseph, Herlyn, Meenhard, Xu, Xiaowei
Published in Clinical and translational medicine (01.06.2022)
Published in Clinical and translational medicine (01.06.2022)
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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Chen, Gang, Huang, Alexander C., Zhang, Wei, Zhang, Gao, Wu, Min, Xu, Wei, Yu, Zili, Yang, Jiegang, Wang, Beike, Sun, Honghong, Xia, Houfu, Man, Qiwen, Zhong, Wenqun, Antelo, Leonardo F., Wu, Bin, Xiong, Xuepeng, Liu, Xiaoming, Guan, Lei, Li, Ting, Liu, Shujing, Yang, Ruifeng, Lu, Youtao, Dong, Liyun, McGettigan, Suzanne, Somasundaram, Rajasekharan, Radhakrishnan, Ravi, Mills, Gordon, Lu, Yiling, Kim, Junhyong, Chen, Youhai H., Dong, Haidong, Zhao, Yifang, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Herlyn, Meenhard, Wherry, E. John, Xu, Xiaowei, Guo, Wei
Published in Nature (London) (01.08.2018)
Published in Nature (London) (01.08.2018)
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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John
Published in Nature (London) (11.07.2019)
Published in Nature (London) (11.07.2019)
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Journal Article
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S., Kurachi, Makoto, Giles, Josephine R., Chen, Zeyu, Casella, Valentina, Ngiow, Shin Foong, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Wherry, E. John
Published in Immunity (Cambridge, Mass.) (19.05.2020)
Published in Immunity (Cambridge, Mass.) (19.05.2020)
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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C., Johnson, John, Staupe, Ryan P., Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S., Vella, Laura A., Baxter, Amy E., Wu, Jennifer E., Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R., Stelekati, Erietta, McLane, Laura M., Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L., Vahedi, Golnaz, Ji, Hongkai, Wherry, E. John
Published in Immunity (Cambridge, Mass.) (19.11.2019)
Published in Immunity (Cambridge, Mass.) (19.11.2019)
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Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells
Bengsch, Bertram, Ohtani, Takuya, Khan, Omar, Setty, Manu, Manne, Sasikanth, O’Brien, Shaun, Gherardini, Pier Federico, Herati, Ramin Sedaghat, Huang, Alexander C., Chang, Kyong-Mi, Newell, Evan W., Bovenschen, Niels, Pe’er, Dana, Albelda, Steven M., Wherry, E. John
Published in Immunity (Cambridge, Mass.) (15.05.2018)
Published in Immunity (Cambridge, Mass.) (15.05.2018)
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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John
Published in Science (American Association for the Advancement of Science) (02.12.2016)
Published in Science (American Association for the Advancement of Science) (02.12.2016)
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T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
Huang, Alexander C., Postow, Michael A., Orlowski, Robert J., Mick, Rosemarie, Bengsch, Bertram, Manne, Sasikanth, Xu, Wei, Harmon, Shannon, Giles, Josephine R., Wenz, Brandon, Adamow, Matthew, Kuk, Deborah, Panageas, Katherine S., Carrera, Cristina, Wong, Phillip, Quagliarello, Felix, Wubbenhorst, Bradley, D’Andrea, Kurt, Pauken, Kristen E., Herati, Ramin S., Staupe, Ryan P., Schenkel, Jason M., McGettigan, Suzanne, Kothari, Shawn, George, Sangeeth M., Vonderheide, Robert H., Amaravadi, Ravi K., Karakousis, Giorgos C., Schuchter, Lynn M., Xu, Xiaowei, Nathanson, Katherine L., Wolchok, Jedd D., Gangadhar, Tara C., Wherry, E. John
Published in Nature (London) (04.05.2017)
Published in Nature (London) (04.05.2017)
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A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma
Huang, Alexander C., Orlowski, Robert J., Xu, Xiaowei, Mick, Rosemarie, George, Sangeeth M., Yan, Patrick K., Manne, Sasikanth, Kraya, Adam A., Wubbenhorst, Bradley, Dorfman, Liza, D’Andrea, Kurt, Wenz, Brandon M., Liu, Shujing, Chilukuri, Lakshmi, Kozlov, Andrew, Carberry, Mary, Giles, Lydia, Kier, Melanie W., Quagliarello, Felix, McGettigan, Suzanne, Kreider, Kristin, Annamalai, Lakshmanan, Zhao, Qing, Mogg, Robin, Xu, Wei, Blumenschein, Wendy M., Yearley, Jennifer H., Linette, Gerald P., Amaravadi, Ravi K., Schuchter, Lynn M., Herati, Ramin S., Bengsch, Bertram, Nathanson, Katherine L., Farwell, Michael D., Karakousis, Giorgos C., Wherry, E. John, Mitchell, Tara C.
Published in Nature medicine (01.03.2019)
Published in Nature medicine (01.03.2019)
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Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph
Published in Nature medicine (01.05.2018)
Published in Nature medicine (01.05.2018)
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Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial
Abella, Benjamin S, Jolkovsky, Eliana L, Biney, Barbara T, Uspal, Julie E, Hyman, Matthew C, Frank, Ian, Hensley, Scott E, Gill, Saar, Vogl, Dan T, Maillard, Ivan, Babushok, Daria V, Huang, Alexander C, Nasta, Sunita D, Walsh, Jennifer C, Wiletyo, E Paul, Gimotty, Phyllis A, Milone, Michael C, Amaravadi, Ravi K
Published in JAMA internal medicine (01.02.2021)
Published in JAMA internal medicine (01.02.2021)
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Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC)
Menzies, Alexander M., Amaria, Rodabe N., Rozeman, Elisa A., Huang, Alexander C., Tetzlaff, Michael T., van de Wiel, Bart A., Lo, Serigne, Tarhini, Ahmad A., Burton, Elizabeth M., Pennington, Thomas E., Saw, Robyn P. M., Xu, Xiaowei, Karakousis, Giorgos C., Ascierto, Paolo A., Spillane, Andrew J., van Akkooi, Alexander C. J., Davies, Michael A., Mitchell, Tara C., Tawbi, Hussein A., Scolyer, Richard A., Wargo, Jennifer A., Blank, Christian U., Long, Georgina V.
Published in Nature medicine (01.02.2021)
Published in Nature medicine (01.02.2021)
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Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Giles, Josephine R., Ngiow, Shin Foong, Manne, Sasikanth, Baxter, Amy E., Khan, Omar, Wang, Ping, Staupe, Ryan, Abdel-Hakeem, Mohamed S., Huang, Hua, Mathew, Divij, Painter, Mark M., Wu, Jennifer E., Huang, Yinghui Jane, Goel, Rishi R., Yan, Patrick K., Karakousis, Giorgos C., Xu, Xiaowei, Mitchell, Tara C., Huang, Alexander C., Wherry, E. John
Published in Nature immunology (01.11.2022)
Published in Nature immunology (01.11.2022)
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