USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
Ji, Lei, Lu, Bo, Zamponi, Raffaella, Charlat, Olga, Aversa, Robert, Yang, Zinger, Sigoillot, Frederic, Zhu, Xiaoping, Hu, Tiancen, Reece-Hoyes, John S., Russ, Carsten, Michaud, Gregory, Tchorz, Jan S., Jiang, Xiaomo, Cong, Feng
Published in Nature communications (13.09.2019)
Published in Nature communications (13.09.2019)
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Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers
Papillon, Julien P. N, Nakajima, Katsumasa, Adair, Christopher D, Hempel, Jonathan, Jouk, Andriana O, Karki, Rajeshri G, Mathieu, Simon, Möbitz, Henrik, Ntaganda, Rukundo, Smith, Troy, Visser, Michael, Hill, Susan E, Hurtado, Felipe Kellermann, Chenail, Gregg, Bhang, Hyo-Eun C, Bric, Anka, Xiang, Kay, Bushold, Geoffrey, Gilbert, Tamara, Vattay, Anthony, Dooley, Julie, Costa, Emily A, Park, Isabel, Li, Ailing, Farley, David, Lounkine, Eugen, Yue, Q. Kimberley, Xie, Xiaoling, Zhu, Xiaoping, Kulathila, Raviraj, King, Daniel, Hu, Tiancen, Vulic, Katarina, Cantwell, John, Luu, Catherine, Jagani, Zainab
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies
Schöffski, Patrick, Tan, Daniel S W, Martín, Miguel, Ochoa-de-Olza, María, Sarantopoulos, John, Carvajal, Richard D, Kyi, Chrisann, Esaki, Taito, Prawira, Amy, Akerley, Wallace, De Braud, Filippo, Hui, Rina, Zhang, Tian, Soo, Ross A, Maur, Michela, Weickhardt, Andrew, Krauss, Jürgen, Deschler-Baier, Barbara, Lau, Allen, Samant, Tanay S, Longmire, Tyler, Chowdhury, Niladri Roy, Sabatos-Peyton, Catherine A, Patel, Nidhi, Ramesh, Radha, Hu, Tiancen, Carion, Ana, Gusenleitner, Daniel, Yerramilli-Rao, Padmaja, Askoxylakis, Vasileios, Kwak, Eunice L, Hong, David S
Published in Journal for immunotherapy of cancer (01.02.2022)
Published in Journal for immunotherapy of cancer (01.02.2022)
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Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity
Hu, Tiancen, Yeh, Jennifer E., Pinello, Luca, Jacob, Jaison, Chakravarthy, Srinivas, Yuan, Guo-Cheng, Chopra, Rajiv, Frank, David A.
Published in Molecular and cellular biology (01.10.2015)
Published in Molecular and cellular biology (01.10.2015)
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A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy
Liu, Si-Qi, Grantham, Alyssa, Landry, Casey, Granda, Brian, Chopra, Rajiv, Chakravarthy, Srinivas, Deutsch, Sabine, Vogel, Markus, Russo, Katie, Seiss, Katherine, Tschantz, William R, Rejtar, Tomas, Ruddy, David A, Hu, Tiancen, Aardalen, Kimberly, Wagner, Joel P, Dranoff, Glenn, D'Alessio, Joseph A
Published in Cancer immunology research (01.01.2021)
Published in Cancer immunology research (01.01.2021)
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Residues on the Dimer Interface of SARS Coronavirus 3C-like Protease: Dimer Stability Characterization and Enzyme Catalytic Activity Analysis
Chen, Shuai, Zhang, Jian, Hu, Tiancen, Chen, Kaixian, Jiang, Hualiang, Shen, Xu
Published in Journal of biochemistry (Tokyo) (01.04.2008)
Published in Journal of biochemistry (Tokyo) (01.04.2008)
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Peptide deformylase is a potential target for anti‐Helicobacter pylori drugs: Reverse docking, enzymatic assay, and X‐ray crystallography validation
Cai, Jianhua, Han, Cong, Hu, Tiancen, Zhang, Jian, Wu, Dalei, Wang, Fangdao, Liu, Yunqing, Ding, Jianping, Chen, Kaixian, Yue, Jianmin, Shen, Xu, Jiang, Hualiang
Published in Protein science (01.09.2006)
Published in Protein science (01.09.2006)
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Characterization of peptide deformylase homologues from Staphylococcus epidermidis
Lin, Penghui, Hu, Tiancen, Hu, Jian, Yu, Wenqi, Han, Cong, Zhang, Jian, Qin, Guangrong, Yu, Kunqian, Götz, Friedrich, Shen, Xu, Jiang, Hualiang, Qu, Di
Published in Microbiology (Society for General Microbiology) (01.10.2010)
Published in Microbiology (Society for General Microbiology) (01.10.2010)
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Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease
Chen, Shuai, Hu, Tiancen, Zhang, Jian, Chen, Jing, Chen, Kaixian, Ding, Jianping, Jiang, Hualiang, Shen, Xu
Published in The Journal of biological chemistry (04.01.2008)
Published in The Journal of biological chemistry (04.01.2008)
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Crystal Structure of HAb18G/CD147
Yu, Xiao-Ling, Hu, Tiancen, Du, Jia-Mu, Ding, Jian-Ping, Yang, Xiang-Min, Zhang, Jian, Yang, Bin, Shen, Xu, Zhang, Zheng, Zhong, Wei-De, Wen, Ning, Jiang, Hualiang, Zhu, Ping, Chen, Zhi-Nan
Published in The Journal of biological chemistry (27.06.2008)
Published in The Journal of biological chemistry (27.06.2008)
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Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies
Bernasconi-Elias, P, Hu, T, Jenkins, D, Firestone, B, Gans, S, Kurth, E, Capodieci, P, Deplazes-Lauber, J, Petropoulos, K, Thiel, P, Ponsel, D, Hee Choi, S, LeMotte, P, London, A, Goetcshkes, M, Nolin, E, Jones, M D, Slocum, K, Kluk, M J, Weinstock, D M, Christodoulou, A, Weinberg, O, Jaehrling, J, Ettenberg, S A, Buckler, A, Blacklow, S C, Aster, J C, Fryer, C J
Published in Oncogene (24.11.2016)
Published in Oncogene (24.11.2016)
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Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region
Xu, Xiang, Choi, Sung Hee, Hu, Tiancen, Tiyanont, Kittichoat, Habets, Roger, Groot, Arjan J., Vooijs, Marc, Aster, Jon C., Chopra, Rajiv, Fryer, Christy, Blacklow, Stephen C.
Published in Structure (London) (07.07.2015)
Published in Structure (London) (07.07.2015)
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Structural Basis for Catalytic and Inhibitory Mechanisms of β-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ)
Zhang, Liang, Liu, Weizhi, Hu, Tiancen, Du, Li, Luo, Cheng, Chen, Kaixian, Shen, Xu, Jiang, Hualiang
Published in The Journal of biological chemistry (29.02.2008)
Published in The Journal of biological chemistry (29.02.2008)
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Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS
Chen, Shuai, Hu, Tiancen, Zhang, Jian, Chen, Jing, Chen, Kaixian, Ding, Jianping, Jiang, Hualiang, Shen, Xu
Published in The Journal of biological chemistry (04.01.2008)
Published in The Journal of biological chemistry (04.01.2008)
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Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor
Schwartz, Stephanie, Patel, Nidhi, Longmire, Tyler, Jayaraman, Pushpa, Jiang, Xiaomo, Lu, Hongbo, Baker, Lisa, Velez, Janelle, Ramesh, Radha, Wavreille, Anne-Sophie, Verneret, Melanie, Fan, Hong, Hu, Tiancen, Xu, Fangmin, Taraszka, John, Pelletier, Marc, Miyashiro, Joy, Rinne, Mikael, Dranoff, Glenn, Sabatos-Peyton, Catherine, Cremasco, Viviana
Published in Immunotherapy advances (01.01.2022)
Published in Immunotherapy advances (01.01.2022)
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Crystal Structure of HAb18G/CD147: IMPLICATIONS FOR IMMUNOGLOBULIN SUPERFAMILY HOMOPHILIC ADHESION
Yu, Xiao-Ling, Hu, Tiancen, Du, Jia-Mu, Ding, Jian-Ping, Yang, Xiang-Min, Zhang, Jian, Yang, Bin, Shen, Xu, Zhang, Zheng, Zhong, Wei-De, Wen, Ning, Jiang, Hualiang, Zhu, Ping, Chen, Zhi-Nan
Published in The Journal of biological chemistry (27.06.2008)
Published in The Journal of biological chemistry (27.06.2008)
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Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure
Hu, Tiancen, Zhang, Yu, Li, Lianwei, Wang, Kuifeng, Chen, Shuai, Chen, Jing, Ding, Jianping, Jiang, Hualiang, Shen, Xu
Published in Virology (New York, N.Y.) (05.06.2009)
Published in Virology (New York, N.Y.) (05.06.2009)
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Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers
Bialucha, Carl U, Collins, Scott D, Li, Xiao, Saxena, Parmita, Zhang, Xiamei, Dürr, Clemens, Lafont, Bruno, Prieur, Pierric, Shim, Yeonju, Mosher, Rebecca, Lee, David, Ostrom, Lance, Hu, Tiancen, Bilic, Sanela, Rajlic, Ivana Liric, Capka, Vladimir, Jiang, Wei, Wagner, Joel P, Elliott, GiNell, Veloso, Artur, Piel, Jessica C, Flaherty, Meghan M, Mansfield, Keith G, Meseck, Emily K, Rubic-Schneider, Tina, London, Anne Serdakowski, Tschantz, William R, Kurz, Markus, Nguyen, Duc, Bourret, Aaron, Meyer, Matthew J, Faris, Jason E, Janatpour, Mary J, Chan, Vivien W, Yoder, Nicholas C, Catcott, Kalli C, McShea, Molly A, Sun, Xiuxia, Gao, Hui, Williams, Juliet, Hofmann, Francesco, Engelman, Jeffrey A, Ettenberg, Seth A, Sellers, William R, Lees, Emma
Published in Cancer discovery (01.09.2017)
Published in Cancer discovery (01.09.2017)
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Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Wu, Dalei, Hu, Tiancen, Zhang, Liang, Chen, Jing, Du, Jiamu, Ding, Jianping, Jiang, Hualiang, Shen, Xu
Published in Protein science (01.06.2008)
Published in Protein science (01.06.2008)
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