Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer
Tang, Chu, Li, Changhao, Zhang, Silong, Hu, Zhiye, Wu, Jun, Dong, Chune, Huang, Jian, Zhou, Hai-Bing
Published in Journal of medicinal chemistry (11.06.2015)
Published in Journal of medicinal chemistry (11.06.2015)
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Journal Article
Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer
He, Ming, Ning, Wentao, Hu, Zhiye, Huang, Jian, Dong, Chune, Zhou, Hai-Bing
Published in European journal of medicinal chemistry (01.06.2020)
Published in European journal of medicinal chemistry (01.06.2020)
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Journal Article
Discovery of Novel Bicyclic Phenylselenyl-Containing Hybrids: An Orally Bioavailable, Potential, and Multiacting Class of Estrogen Receptor Modulators against Endocrine-Resistant Breast Cancer
Deng, Xiangping, Xie, Baohua, Li, Qiuzi, Xiao, Yuan, Hu, Zhiye, Deng, Xiaofei, Fang, Pingping, Dong, Chune, Zhou, Hai-Bing, Huang, Jian
Published in Journal of medicinal chemistry (09.06.2022)
Published in Journal of medicinal chemistry (09.06.2022)
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Journal Article
Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In Vivo
Xie, Baohua, Yin, Zhinang, Hu, Zhiye, Lv, Junhui, Du, Chuanqian, Deng, Xiangping, Huang, Yuan, Li, Qiuzi, Huang, Jian, Liang, Kaiwei, Zhou, Hai-Bing, Dong, Chune
Published in Journal of medicinal chemistry (25.05.2023)
Published in Journal of medicinal chemistry (25.05.2023)
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Journal Article
Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer
Deng, Xiangping, Deng, Xiaofei, Ning, Wentao, Xin, Lilan, Li, Qiuzi, Hu, Zhiye, Xie, Baohua, Liang, Kaiwei, Min, Chang, Dong, Chune, Huang, Jian, Zhou, Hai-Bing
Published in Journal of medicinal chemistry (24.08.2023)
Published in Journal of medicinal chemistry (24.08.2023)
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Journal Article
Novel hybrid conjugates with dual estrogen receptor α degradation and histone deacetylase inhibitory activities for breast cancer therapy
Zhao, Chenxi, Tang, Chu, Li, Changhao, Ning, Wentao, Hu, Zhiye, Xin, Lilan, Zhou, Hai-Bing, Huang, Jian
Published in Bioorganic & medicinal chemistry (15.06.2021)
Published in Bioorganic & medicinal chemistry (15.06.2021)
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Journal Article
Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer
Ning, Wentao, Hu, Zhiye, Tang, Chu, Yang, Lu, Zhang, Silong, Dong, Chune, Huang, Jian, Zhou, Hai-Bing
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Journal Article
Exploring the PROTAC degron candidates: OBHSA with different side chains as novel selective estrogen receptor degraders (SERDs)
Li, Yuanyuan, Zhang, Silong, Zhang, Jing, Hu, Zhiye, Xiao, Yuan, Huang, Jian, Dong, Chune, Huang, Shengtang, Zhou, Hai-Bing
Published in European journal of medicinal chemistry (15.06.2019)
Published in European journal of medicinal chemistry (15.06.2019)
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Journal Article
Rational design of ERα targeting hypoxia turn-on fluorescent probes with antiproliferative activity for breast cancer
Meng, Qiuyu, Xie, Baohua, Ma, Xiaoyu, Hu, Zhiye, Zhou, Fuling, Zhou, Hai-Bing, Dong, Chune
Published in Chemical communications (Cambridge, England) (16.09.2020)
Published in Chemical communications (Cambridge, England) (16.09.2020)
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Journal Article
Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader
Zhao, Yue, Zhao, Chenxi, Lu, Jin, Wu, Jun, Li, Changhao, Hu, Zhiye, Tian, Wei, Yang, Liang, Xiang, Jin, Zhou, Haibin, Deng, Zixin, Huang, Jian, Hong, Kui
Published in Pharmacological research (01.08.2019)
Published in Pharmacological research (01.08.2019)
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Journal Article
Construction of benzofuranone library via a metal-free, one-pot intermolecular condensation, and their application as efficient estrogen receptor β modulators
Peng, Xueke, Hu, Zhiye, Zhang, Jing, Ning, Wentao, Zhang, Silong, Dong, Chune, Shi, Xiaodong, Zhou, Hai-Bing
Published in Chemical communications (Cambridge, England) (18.12.2019)
Published in Chemical communications (Cambridge, England) (18.12.2019)
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Journal Article
Novel class of 7-Oxabicyclo[2.2.1]heptene sulfonamides with long alkyl chains displaying improved estrogen receptor α degradation activity
Hu, Zhiye, Li, Yuanyuan, Xie, Baohua, Ning, Wentao, Xiao, Yuan, Huang, Yuan, Zhao, Chenxi, Huang, Jian, Dong, Chune, Zhou, Hai-Bing
Published in European journal of medicinal chemistry (15.11.2019)
Published in European journal of medicinal chemistry (15.11.2019)
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Journal Article
Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy
Yang, Lu, Hu, Zhiye, Luo, Junjie, Tang, Chu, Zhang, Silong, Ning, Wentao, Dong, Chune, Huang, Jian, Liu, Xianjun, Zhou, Hai-Bing
Published in Bioorganic & medicinal chemistry (01.07.2017)
Published in Bioorganic & medicinal chemistry (01.07.2017)
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Journal Article
Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reactionElectronic supplementary information (ESI) available: NMR and HPLC spectra of all compounds. See DOI: 10.1039/c7ob02794j
Zheng, Jie, He, Ming, Xie, Baohua, Yang, Lu, Hu, Zhiye, Zhou, Hai-Bing, Dong, Chune
Year of Publication 17.01.2018
Year of Publication 17.01.2018
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Journal Article
A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cellsElectronic supplementary information (ESI) available: Detailed experimental procedures, and 1H NMR and 13C NMR spectra of the compounds are provided. See DOI: 10.1039/c8cc00483h
Hu, Zhiye, Yang, Lu, Ning, Wentao, Tang, Chu, Meng, Qiuyu, Zheng, Jie, Dong, Chune, Zhou, Hai-Bing
Year of Publication 12.04.2018
Year of Publication 12.04.2018
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Journal Article
Synthesis and structure–activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy
Li, Changhao, Tang, Chu, Hu, Zhiye, Zhao, Chenxi, Li, Chenlu, Zhang, Silong, Dong, Chune, Zhou, Hai-Bing, Huang, Jian
Published in Bioorganic & medicinal chemistry (01.07.2016)
Published in Bioorganic & medicinal chemistry (01.07.2016)
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Journal Article
Selenophenes: Introducing a New Element into the Core of Non‐Steroidal Estrogen Receptor Ligands
Zhang, Silong, Wang, Zhiyong, Hu, Zhiye, Li, Changhao, Tang, Chu, Carlson, Kathryn E., Luo, Junjie, Dong, Chune, Katzenellenbogen, John A., Huang, Jian, Zhou, Hai‐Bing
Published in ChemMedChem (03.02.2017)
Published in ChemMedChem (03.02.2017)
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Journal Article
Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy
Luo, Junjie, Hu, Zhiye, Xiao, Yuan, Yang, Tongxin, Dong, Chune, Huang, Jian, Zhou, Hai-Bing
Published in MedChemComm (01.07.2017)
Published in MedChemComm (01.07.2017)
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