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Published in Journal of medicinal chemistry (21.09.2006)
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Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors
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The development of a high-affinity conformation-sensitive antibody mimetic using a biocompatible copolymer carrier (iBody)
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Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex
Brynda, Jiří, Řezáčová, Pavlína, Fábry, Milan, Hořejší, Magdalena, Štouračová, Renata, Souček, Milan, Hradílek, Martin, Konvalinka, Jan, Sedláček, Juraj
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2004)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2004)
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Structural and Biochemical Characterization of a Novel Aminopeptidase from Human Intestine
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Published in The Journal of biological chemistry (01.05.2015)
Published in The Journal of biological chemistry (01.05.2015)
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Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni : From Functional Analysis to Anti-schistosomal Inhibitors: e0003827
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Two aspartic proteinases secreted by the pathogenic yeast Candida parapsilosis differ in expression pattern and catalytic properties
Hrušková-Heidingsfeldová, Olga, Dostál, Jiří, Majer, Filip, Havlíková, Jana, Hradilek, Martin, Pichová, Iva
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Published in Biological chemistry (01.03.2009)
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On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 Å resolution
Dušková, Jarmila, Dohnálek, Jan, Skálová, Tereza, Petroková, Hana, Vondráčková, Eva, Hradílek, Martin, Konvalinka, Jan, Souček, Milan, Brynda, Jiří, Fábry, Milan, Sedláček, Juraj, Hašek, Jindřich
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Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2006)
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Single- and Double-Headed Chemical Probes for Detection of Active Cathepsin D in a Cancer Cell Proteome
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Published in Chembiochem : a European journal of chemical biology (26.07.2010)
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A Phenylnorstatine Inhibitor Binding to HIV-1 Protease: Geometry, Protonation, and Subsite−Pocket Interactions Analyzed at Atomic Resolution
Brynda, Jiri, Rezacova, Pavlina, Fabry, Milan, Horejsi, Magdalena, Stouracova, Renata, Sedlacek, Juraj, Soucek, Milan, Hradilek, Martin, Lepsik, Martin, Konvalinka, Jan
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Published in Journal of medicinal chemistry (08.04.2004)
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Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
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Published in Biological chemistry (01.09.2006)
Published in Biological chemistry (01.09.2006)
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Configurations of Diastereomeric Hydroxyethylene Isosteres Strongly Affect Biological Activities of a Series of Specific Inhibitors of Human‐Immunodeficiency‐Virus Proteinase
Konvalinka, Jan, Litera, Jaroslav, Weber, Jan, Vondrášek, Jiří, Hradílek, Martin, Souček, Milan, Pichová, Iva, Majer, Pavel, Štrop, Petr, Sedlácek, Juraj, Heuser, Anke‐Mareil, Kottler, Hubert, Kräusslich, Hans‐Georg
Published in European journal of biochemistry (01.12.1997)
Published in European journal of biochemistry (01.12.1997)
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Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors
Caffrey, Conor R., Placha, Lenka, Barinka, Cyril, Hradilek, Martin, Dostál, Jiří, Sajid, Mohammed, McKerrow, James H., Majer, Pavel, Konvalinka, Jan, Vondrášek, Jiří
Published in Biological chemistry (01.04.2005)
Published in Biological chemistry (01.04.2005)
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Hydroxyethylamine Isostere of an HIV-1 Protease Inhibitor Prefers Its Amine to the Hydroxy Group in Binding to Catalytic Aspartates. A Synchrotron Study of HIV-1 Protease in Complex with a Peptidomimetic Inhibitor
Dohnálek, Jan, Hašek, Jindřich, Dušková, Jarmila, Petroková, Hana, Hradilek, Martin, Souček, Milan, Konvalinka, Jan, Brynda, Jiří, Sedláček, Juraj, Fábry, Milan
Published in Journal of medicinal chemistry (28.03.2002)
Published in Journal of medicinal chemistry (28.03.2002)
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A Picomolar Inhibitor of Resistant Strains of Human Immunodeficiency Virus Protease Identified by a Combinatorial Approach
Rinnová, Markéta, Hradilek, Martin, Bařinka, Cyril, Weber, Jan, Souček, Milan, Vondrášek, Jiřı́, Klimkait, Thomas, Konvalinka, Jan
Published in Archives of biochemistry and biophysics (01.10.2000)
Published in Archives of biochemistry and biophysics (01.10.2000)
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On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 Aa resolution
Duskova, Jarmila, Dohnalek, Jan, Skalova, Tereza, Petrokova, Hana, Vondrackova, Eva, Hradilek, Martin, Konvalinka, Jan, Soucek, Milan, Brynda, Jiri, Fabry, Milan, Sedlacek, Juraj, Hasek, Jindrich
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2006)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2006)
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A distinct binding mode of a hydroxyethylamine isostere inhibitor of HIV-1 protease
Dohnálek, Jan, Hašek, Jindřich, Dušková, Jarmila, Petroková, Hana, Hradilek, Martin, Souček, Milan, Konvalinka, Jan, Brynda, Jiří, Sedláček, Juraj, Fábry, Milan
Published in Acta crystallographica. Section D, Biological crystallography. (01.03.2001)
Published in Acta crystallographica. Section D, Biological crystallography. (01.03.2001)
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