Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
Chalupova, Katarina, Korabecny, Jan, Bartolini, Manuela, Monti, Barbara, Lamba, Doriano, Caliandro, Rosanna, Pesaresi, Alessandro, Brazzolotto, Xavier, Gastellier, Anne-Julie, Nachon, Florian, Pejchal, Jaroslav, Jarosova, Michaela, Hepnarova, Vendula, Jun, Daniel, Hrabinova, Martina, Dolezal, Rafael, Zdarova Karasova, Jana, Mzik, Martin, Kristofikova, Zdena, Misik, Jan, Muckova, Lubica, Jost, Petr, Soukup, Ondrej, Benkova, Marketa, Setnicka, Vladimir, Habartova, Lucie, Chvojkova, Marketa, Kleteckova, Lenka, Vales, Karel, Mezeiova, Eva, Uliassi, Elisa, Valis, Martin, Nepovimova, Eugenie, Bolognesi, Maria Laura, Kuca, Kamil
Published in European journal of medicinal chemistry (15.04.2019)
Published in European journal of medicinal chemistry (15.04.2019)
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Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules
Hamulakova, Slavka, Poprac, Patrik, Jomova, Klaudia, Brezova, Vlasta, Lauro, Peter, Drostinova, Lenka, Jun, Daniel, Sepsova, Vendula, Hrabinova, Martina, Soukup, Ondrej, Kristian, Pavol, Gazova, Zuzana, Bednarikova, Zuzana, Kuca, Kamil, Valko, Marian
Published in Journal of inorganic biochemistry (01.08.2016)
Published in Journal of inorganic biochemistry (01.08.2016)
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Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity
Šafratová, Marcela, Hošťálková, Anna, Hulcová, Daniela, Breiterová, Kateřina, Hrabcová, Veronika, Machado, Marta, Fontinha, Diana, Prudêncio, Miguel, Kuneš, Jiří, Chlebek, Jakub, Jun, Daniel, Hrabinová, Martina, Nováková, Lucie, Havelek, Radim, Seifrtová, Martina, Opletal, Lubomír, Cahlíková, Lucie
Published in Archives of pharmacal research (01.02.2018)
Published in Archives of pharmacal research (01.02.2018)
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Is It the Twilight of BACE1 Inhibitors?
Hrabinova, Martina, Pejchal, Jaroslav, Kucera, Tomas, Jun, Daniel, Schmidt, Monika, Soukup, Ondrej
Published in Current neuropharmacology (2021)
Published in Current neuropharmacology (2021)
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Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease
Mezeiova, Eva, Prchal, Lukas, Hrabinova, Martina, Muckova, Lubica, Pulkrabkova, Lenka, Soukup, Ondrej, Misiachna, Anna, Janousek, Jiri, Fibigar, Jakub, Kucera, Tomas, Horak, Martin, Makhaeva, Galina F., Korabecny, Jan
Published in Biomedicine & pharmacotherapy (01.04.2024)
Published in Biomedicine & pharmacotherapy (01.04.2024)
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Structure-Guided Design of N -Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease
Svobodova, Barbora, Pulkrabkova, Lenka, Panek, Dawid, Misiachna, Anna, Kolcheva, Marharyta, Andrys, Rudolf, Handl, Jiri, Capek, Jan, Nyvltova, Pavlina, Rousar, Tomas, Prchal, Lukas, Hepnarova, Vendula, Hrabinova, Martina, Muckova, Lubica, Tosnerova, Daniela, Karabanovich, Galina, Finger, Vladimir, Soukup, Ondrej, Horak, Martin, Korabecny, Jan
Published in International journal of molecular sciences (23.05.2023)
Published in International journal of molecular sciences (23.05.2023)
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Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment
Schmidt, Monika, Benek, Ondrej, Vinklarova, Lucie, Hrabinova, Martina, Zemanova, Lucie, Chribek, Matej, Kralova, Vendula, Hroch, Lukas, Dolezal, Rafael, Lycka, Antonin, Prchal, Lukas, Jun, Daniel, Aitken, Laura, Gunn-Moore, Frank, Kuca, Kamil, Musilek, Kamil
Published in International journal of molecular sciences (17.03.2020)
Published in International journal of molecular sciences (17.03.2020)
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7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
Korabecny, Jan, Andrs, Martin, Nepovimova, Eugenie, Dolezal, Rafael, Babkova, Katerina, Horova, Anna, Malinak, David, Mezeiova, Eva, Gorecki, Lukas, Sepsova, Vendula, Hrabinova, Martina, Soukup, Ondrej, Jun, Daniel, Kuca, Kamil
Published in Molecules (Basel, Switzerland) (10.12.2015)
Published in Molecules (Basel, Switzerland) (10.12.2015)
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Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
Gorecki, Lukas, Hepnarova, Vendula, Karasova, Jana Zdarova, Hrabinova, Martina, Courageux, Charlotte, Dias, José, Kucera, Tomas, Kobrlova, Tereza, Muckova, Lubica, Prchal, Lukas, Malinak, David, Jun, Daniel, Musilek, Kamil, Worek, Franz, Nachon, Florian, Soukup, Ondrej, Korabecny, Jan
Published in Archives of toxicology (01.03.2021)
Published in Archives of toxicology (01.03.2021)
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Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease
Kohelová, Eliška, Peřinová, Rozálie, Maafi, Negar, Korábečný, Jan, Hulcová, Daniela, Maříková, Jana, Kučera, Tomáš, Martínez González, Loreto, Hrabinova, Martina, Vorčáková, Katarina, Nováková, Lucie, De Simone, Angela, Havelek, Radim, Cahlíková, Lucie
Published in Molecules (Basel, Switzerland) (03.04.2019)
Published in Molecules (Basel, Switzerland) (03.04.2019)
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Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
Mezeiova, Eva, Korabecny, Jan, Sepsova, Vendula, Hrabinova, Martina, Jost, Petr, Muckova, Lubica, Kucera, Tomas, Dolezal, Rafael, Misik, Jan, Spilovska, Katarina, Pham, Ngoc Lam, Pokrievkova, Lucia, Roh, Jaroslav, Jun, Daniel, Soukup, Ondrej, Kaping, Daniel, Kuca, Kamil
Published in Molecules (Basel, Switzerland) (28.07.2017)
Published in Molecules (Basel, Switzerland) (28.07.2017)
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A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
Kuca, Kamil, Musilek, Kamil, Jun, Daniel, Zdarova-Karasova, Jana, Nepovimova, Eugenie, Soukup, Ondrej, Hrabinova, Martina, Mikler, John, Franca, Tanos C C, Da Cunha, Elaine F F, De Castro, Alexandre A, Valis, Martin, Ramalho, Teodorico C
Published in BMC pharmacology & toxicology (21.02.2018)
Published in BMC pharmacology & toxicology (21.02.2018)
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Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier
Hamulakova, Slavka, Janovec, Ladislav, Soukup, Ondrej, Jun, Daniel, Janockova, Jana, Hrabinova, Martina, Sepsova, Vendula, Kuca, Kamil
Published in Current Alzheimer research (01.01.2018)
Published in Current Alzheimer research (01.01.2018)
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Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors
Svobodova, Barbora, Mezeiova, Eva, Hepnarova, Vendula, Hrabinova, Martina, Muckova, Lubica, Kobrlova, Tereza, Jun, Daniel, Soukup, Ondrej, Jimeno, María Luisa, Marco-Contelles, José, Korabecny, Jan
Published in Biomolecules (Basel, Switzerland) (19.08.2019)
Published in Biomolecules (Basel, Switzerland) (19.08.2019)
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Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
Kuca, Kamil, Jun, Daniel, Junova, Lucie, Musilek, Kamil, Hrabinova, Martina, da Silva, Jorge Alberto Valle, Ramalho, Teodorico Castro, Valko, Marian, Wu, Qinghua, Nepovimova, Eugenie, França, Tanos Celmar Costa
Published in Molecules (Basel, Switzerland) (07.05.2018)
Published in Molecules (Basel, Switzerland) (07.05.2018)
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Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N -Methyl-d-Aspartate Receptor Antagonists
Konecny, Jan, Misiachna, Anna, Hrabinova, Martina, Pulkrabkova, Lenka, Benkova, Marketa, Prchal, Lukas, Kucera, Tomas, Kobrlova, Tereza, Finger, Vladimir, Kolcheva, Marharyta, Kortus, Stepan, Jun, Daniel, Valko, Marian, Horak, Martin, Soukup, Ondrej, Korabecny, Jan
Published in Biomolecules (Basel, Switzerland) (22.12.2020)
Published in Biomolecules (Basel, Switzerland) (22.12.2020)
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In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Soukup, Ondrej, Korabecny, Jan, Malinak, David, Nepovimova, Eugenie, Pham, Ngoc L, Musilek, Kamil, Hrabinova, Martina, Hepnarova, Vendula, Dolezal, Rafael, Pavek, Petr, Jost, Petr, Kobrlova, Tereza, Jankockova, Jana, Gorecki, Lukas, Psotka, Miroslav, Nguyen, Thuy D, Box, Karl, Outhwaite, Breeze, Ceckova, Martina, Sorf, Ales, Jun, Daniel, Kuca, Kamil
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.05.2018)
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.05.2018)
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Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment
Musilek, Kamil, Komloova, Marketa, Holas, Ondrej, Hrabinova, Martina, Pohanka, Miroslav, Dohnal, Vlastimil, Nachon, Florian, Dolezal, Martin, Kuca, Kamil
Published in European journal of medicinal chemistry (01.02.2011)
Published in European journal of medicinal chemistry (01.02.2011)
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Alkaloids from Peumus boldus and their Acetylcholinesterase, Butyrylcholinesterase and Prolyl Oligopeptidase Inhibition Activity
Hošt'álková, Anna, Opletal, Lubomír, Kuneš, Jiří, Novák, Zdeněk, Hrabinová, Martina, Chlebek, Jakub, Čegan, Lukáš, Cahlíková, Lucie
Published in Natural product communications (01.04.2015)
Published in Natural product communications (01.04.2015)
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