Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase
Hoxhaj, Gerta, Ben-Sahra, Issam, Lockwood, Sophie E, Timson, Rebecca C, Byles, Vanessa, Henning, Graham T, Gao, Peng, Selfors, Laura M, Asara, John M, Manning, Brendan D
Published in Science (American Association for the Advancement of Science) (08.03.2019)
Published in Science (American Association for the Advancement of Science) (08.03.2019)
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Journal Article
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Ben-Sahra, Issam, Hoxhaj, Gerta, Ricoult, Stéphane J. H., Asara, John M., Manning, Brendan D.
Published in Science (American Association for the Advancement of Science) (12.02.2016)
Published in Science (American Association for the Advancement of Science) (12.02.2016)
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Journal Article
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
Menon, Suchithra, Dibble, Christian C., Talbott, George, Hoxhaj, Gerta, Valvezan, Alexander J., Takahashi, Hidenori, Cantley, Lewis C., Manning, Brendan D.
Published in Cell (13.02.2014)
Published in Cell (13.02.2014)
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Journal Article
Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex
Howell, Jessica J., Hellberg, Kristina, Turner, Marc, Talbott, George, Kolar, Matthew J., Ross, Debbie S., Hoxhaj, Gerta, Saghatelian, Alan, Shaw, Reuben J., Manning, Brendan D.
Published in Cell metabolism (07.02.2017)
Published in Cell metabolism (07.02.2017)
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Journal Article
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
Soflaee, Mona Hoseini, Kesavan, Rushendhiran, Sahu, Umakant, Tasdogan, Alpaslan, Villa, Elodie, Djabari, Zied, Cai, Feng, Tran, Diem H, Vu, Hieu S, Ali, Eunus S, Rion, Halie, O'Hara, Brendan P, Kelekar, Sherwin, Hallett, James Hughes, Martin, Misty, Mathews, Thomas P, Gao, Peng, Asara, John M, Manning, Brendan D, Ben-Sahra, Issam, Hoxhaj, Gerta
Published in Nature communications (16.05.2022)
Published in Nature communications (16.05.2022)
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Journal Article
Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
Heintz, Caroline, Doktor, Thomas Koed, Lanjuin, Anne, Escoubas, Caroline, Zhang, Yue, Weir, Heather J, Dutta, Sneha, Silva-García, Carlos Giovanni, Bruun, Gitte Hoffmann, Morantte, Ianessa, Hoxhaj, Gerta, Manning, Brendan D, Andresen, Brage S, Mair, William B
Published in Nature (London) (05.01.2017)
Published in Nature (London) (05.01.2017)
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Journal Article
GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing
Yu, Dong-Min, Zhao, Jiawei, Lee, Eunice E, Kim, Dohun, Mahapatra, Ruchika, Rose, Elysha K, Zhou, Zhiwei, Hosler, Calvin, El Kurdi, Abdullah, Choe, Jun-Yong, Abel, E Dale, Hoxhaj, Gerta, Westover, Kenneth D, Cho, Raymond J, Cheng, Jeffrey B, Wang, Richard C
Published in The Journal of clinical investigation (01.11.2023)
Published in The Journal of clinical investigation (01.11.2023)
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Journal Article
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
Schrötter, Sandra, Yuskaitis, Christopher J., MacArthur, Michael R., Mitchell, Sarah J., Hosios, Aaron M., Osipovich, Maria, Torrence, Margaret E., Mitchell, James R., Hoxhaj, Gerta, Sahin, Mustafa, Manning, Brendan D.
Published in Cell reports (Cambridge) (17.05.2022)
Published in Cell reports (Cambridge) (17.05.2022)
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Journal Article
The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids
Hoxhaj, Gerta, Caddye, Edward, Najafov, Ayaz, Houde, Vanessa P, Johnson, Catherine, Dissanayake, Kumara, Toth, Rachel, Campbell, David G, Prescott, Alan R, MacKintosh, Carol
Published in eLife (22.04.2016)
Published in eLife (22.04.2016)
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Journal Article
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin
Byles, Vanessa, Cormerais, Yann, Kalafut, Krystle, Barrera, Victor, Hughes Hallett, James E., Sui, Shannan Ho, Asara, John M., Adams, Christopher M., Hoxhaj, Gerta, Ben-Sahra, Issam, Manning, Brendan D.
Published in Molecular metabolism (Germany) (01.11.2021)
Published in Molecular metabolism (Germany) (01.11.2021)
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Journal Article
Itaconate-producing neutrophils regulate local and systemic inflammation following trauma
Crossley, Janna L, Ostashevskaya-Gohstand, Sonya, Comazzetto, Stefano, Hook, Jessica S, Guo, Lei, Vishlaghi, Neda, Juan, Conan, Xu, Lin, Horswill, Alexander R, Hoxhaj, Gerta, Moreland, Jessica G, Tower, Robert J, Levi, Benjamin
Published in JCI insight (23.10.2023)
Published in JCI insight (23.10.2023)
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Journal Article
MENA is a transcriptional target of the Wnt/beta-catenin pathway
Najafov, Ayaz, Seker, Tuncay, Even, Ipek, Hoxhaj, Gerta, Selvi, Osman, Ozel, Duygu Esen, Koman, Ahmet, Birgül-İyison, Necla
Published in PloS one (17.05.2012)
Published in PloS one (17.05.2012)
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Journal Article
Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets
Kavak, Ersen, Najafov, Ayaz, Ozturk, Nuri, Seker, Tuncay, Cavusoglu, Kader, Aslan, Tolga, Duru, Adil Doganay, Saygili, Tahsin, Hoxhaj, Gerta, Hiz, Mahmut Can, Unal, Durisehvar Ozer, Birgül-İyison, Necla, Ozturk, Mehmet, Koman, Ahmet
Published in Cellular signalling (01.10.2010)
Published in Cellular signalling (01.10.2010)
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Journal Article
Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase
Hoxhaj, Gerta, Najafov, Ayaz, Toth, Rachel, Campbell, David G, Prescott, Alan R, MacKintosh, Carol
Published in Journal of cell science (15.03.2022)
Published in Journal of cell science (15.03.2022)
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