An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtII Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates
Merkul, Eugen, Muns, Joey A., Sijbrandi, Niels J., Houthoff, Hendrik‐Jan, Nijmeijer, Bart, Rheenen, Gerro, Reedijk, Jan, Dongen, Guus A. M. S.
Published in Angewandte Chemie International Edition (08.02.2021)
Published in Angewandte Chemie International Edition (08.02.2021)
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A successful search for new, efficient, and silver-free manufacturing processes for key platinum() intermediates applied in antibody-drug conjugate (ADC) production
Merkul, Eugen, Sijbrandi, Niels J, Aydin, Ibrahim, Muns, Joey A, Peters, Ruud J. R. W, Laarhoven, Paul, Houthoff, Hendrik-Jan, van Dongen, Guus A. M. S
Published in Green chemistry : an international journal and green chemistry resource : GC (07.04.2020)
Published in Green chemistry : an international journal and green chemistry resource : GC (07.04.2020)
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A Novel Platinum(II)-Based Bifunctional ADC Linker Benchmarked Using 89Zr-Desferal and Auristatin F-Conjugated Trastuzumab
Sijbrandi, Niels J, Merkul, Eugen, Muns, Joey A, Waalboer, Dennis C J, Adamzek, Kevin, Bolijn, Marije, Montserrat, Veronica, Somsen, Govert W, Haselberg, Rob, Steverink, Paul J G M, Houthoff, Hendrik-Jan, van Dongen, Guus A M S
Published in Cancer research (Chicago, Ill.) (15.01.2017)
Published in Cancer research (Chicago, Ill.) (15.01.2017)
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Platinum(II) as Bifunctional Linker in Antibody-Drug Conjugate Formation: Coupling of a 4-Nitrobenzo-2-oxa-1,3-diazole Fluorophore to Trastuzumab as a Model
Waalboer, Dennis C. J., Muns, Joey A., Sijbrandi, Niels J., Schasfoort, Richard B. M., Haselberg, Rob, Somsen, Govert W., Houthoff, Hendrik-Jan, van Dongen, Guus A. M. S.
Published in ChemMedChem (01.05.2015)
Published in ChemMedChem (01.05.2015)
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An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt II Linker Lx for Improved Manufacturability of Antibody-Drug Conjugates
Merkul, Eugen, Muns, Joey A, Sijbrandi, Niels J, Houthoff, Hendrik-Jan, Nijmeijer, Bart, van Rheenen, Gerro, Reedijk, Jan, van Dongen, Guus A M S
Published in Angewandte Chemie International Edition (08.02.2021)
Published in Angewandte Chemie International Edition (08.02.2021)
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Journal Article
First platinum(II)-based metal-organic linker technology (Lx®) for a plug-and-play development of antibody-drug conjugates (ADCs)
Merkul, Eugen, Sijbrandi, Niels J., Muns, Joey A., Aydin, Ibrahim, Adamzek, Kevin, Houthoff, Hendrik-Jan, Nijmeijer, Bart, Van Dongen, Guus A.M.S.
Published in Expert opinion on drug delivery (03.08.2019)
Published in Expert opinion on drug delivery (03.08.2019)
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Titelbild: An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtII Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates (Angew. Chem. 6/2021)
Merkul, Eugen, Muns, Joey A., Sijbrandi, Niels J., Houthoff, Hendrik‐Jan, Nijmeijer, Bart, Rheenen, Gerro, Reedijk, Jan, Dongen, Guus A. M. S.
Published in Angewandte Chemie (08.02.2021)
Published in Angewandte Chemie (08.02.2021)
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Journal Article
An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtII Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates
Merkul, Eugen, Muns, Joey A., Sijbrandi, Niels J., Houthoff, Hendrik‐Jan, Nijmeijer, Bart, Rheenen, Gerro, Reedijk, Jan, Dongen, Guus A. M. S.
Published in Angewandte Chemie (08.02.2021)
Published in Angewandte Chemie (08.02.2021)
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Cover Picture: An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt II Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates (Angew. Chem. Int. Ed. 6/2021)
Merkul, Eugen, Muns, Joey A., Sijbrandi, Niels J., Houthoff, Hendrik‐Jan, Nijmeijer, Bart, van Rheenen, Gerro, Reedijk, Jan, van Dongen, Guus A. M. S.
Published in Angewandte Chemie International Edition (08.02.2021)
Published in Angewandte Chemie International Edition (08.02.2021)
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Journal Article
Cover Picture: An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtII Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates (Angew. Chem. Int. Ed. 6/2021)
Merkul, Eugen, Muns, Joey A., Sijbrandi, Niels J., Houthoff, Hendrik‐Jan, Nijmeijer, Bart, Rheenen, Gerro, Reedijk, Jan, Dongen, Guus A. M. S.
Published in Angewandte Chemie International Edition (08.02.2021)
Published in Angewandte Chemie International Edition (08.02.2021)
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Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice
Xenaki, Katerina T, Dorrestijn, Bram, Muns, Joey A, Adamzek, Kevin, Doulkeridou, Sofia, Houthoff, HendrikJan, Oliveira, Sabrina, van Bergen En Henegouwen, Paul Mp
Published in Theranostics (01.01.2021)
Published in Theranostics (01.01.2021)
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In Vivo Characterization of Platinum(II)-Based Linker Technology for the Development of Antibody–Drug Conjugates: Taking Advantage of Dual Labeling with ^sup 195m^Pt and ^sup 89^Zr
Muns, Joey A, Montserrat, Veronica, Houthoff, Hendrik-Jan, der Schilden, Karlijn Codée-van, Zwaagstra, Oene, Sijbrandi, Niels J, Merkul, Eugen, van Dongen, Guus AMS
Published in The Journal of nuclear medicine (1978) (01.07.2018)
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Published in The Journal of nuclear medicine (1978) (01.07.2018)
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In Vivo Characterization of Platinum(II)-Based Linker Technology for the Development of Antibody-Drug Conjugates: Taking Advantage of Dual Labeling with 195m Pt and 89 Zr
Muns, Joey A, Montserrat, Veronica, Houthoff, Hendrik-Jan, Codée-van der Schilden, Karlijn, Zwaagstra, Oene, Sijbrandi, Niels J, Merkul, Eugen, van Dongen, Guus A M S
Published in Journal of Nuclear Medicine (01.07.2018)
Published in Journal of Nuclear Medicine (01.07.2018)
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Journal Article
Titelbild: An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt II Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates (Angew. Chem. 6/2021)
Merkul, Eugen, Muns, Joey A., Sijbrandi, Niels J., Houthoff, Hendrik‐Jan, Nijmeijer, Bart, van Rheenen, Gerro, Reedijk, Jan, van Dongen, Guus A. M. S.
Published in Angewandte Chemie (08.02.2021)
Published in Angewandte Chemie (08.02.2021)
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Journal Article
An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt II Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates
Merkul, Eugen, Muns, Joey A., Sijbrandi, Niels J., Houthoff, Hendrik‐Jan, Nijmeijer, Bart, van Rheenen, Gerro, Reedijk, Jan, van Dongen, Guus A. M. S.
Published in Angewandte Chemie (08.02.2021)
Published in Angewandte Chemie (08.02.2021)
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Journal Article
In Vivo Characterization of Platinum(II)-Based Linker Technology for the Development of Antibody-Drug Conjugates: Taking Advantage of Dual Labeling with 195mPt and 89Zr
Muns, Joey A, Montserrat, Veronica, Houthoff, Hendrik-Jan, Codée-van der Schilden, Karlijn, Zwaagstra, Oene, Sijbrandi, Niels J, Merkul, Eugen, van Dongen, Guus A M S
Published in The Journal of nuclear medicine (1978) (01.07.2018)
Published in The Journal of nuclear medicine (1978) (01.07.2018)
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INTERNALIZING BINDING MOLECULES TARGETING RECEPTORS INVOLVED IN CELL PROLIFERATION OR CELL DIFFERENTIATION
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Year of Publication 28.08.2024
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Year of Publication 28.08.2024
Patent
INTERNALIZING BINDING MOLECULES TARGETING RECEPTORS INVOLVED IN CELL PROLIFERATION OR CELL DIFFERENTIATION
HOUTHOFF, Hendrik Jan, VAN BERGEN EN HENEGOUWEN, Paulus Martinus Petrus, PRONK, Sebas Daniël, MUNS, Joey Armand, SIJBRANDI, Niels Jurriaan, SCHOOTEN, Jan Hendrik
Year of Publication 12.06.2024
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Year of Publication 12.06.2024
Patent
INTERNALIZING BINDING MOLECULES TARGETING RECEPTORS INVOLVED IN CELL PROLIFERATION OR CELL DIFFERENTIATION
HOUTHOFF, Hendrik Jan, VAN BERGEN EN HENEGOUWEN, Paulus Martinus Petrus, PRONK, Sebas Daniël, MUNS, Joey Armand, SIJBRANDI, Niels Jurriaan, SCHOOTEN, Jan Hendrik
Year of Publication 12.06.2024
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Year of Publication 12.06.2024
Patent