Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification
Ding, Yi, Hou, Kangcheng, Burch, Kathryn S, Lapinska, Sandra, Privé, Florian, Vilhjálmsson, Bjarni, Sankararaman, Sriram, Pasaniuc, Bogdan
Published in Nature genetics (01.01.2022)
Published in Nature genetics (01.01.2022)
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Journal Article
Efficient variance components analysis across millions of genomes
Pazokitoroudi, Ali, Wu, Yue, Burch, Kathryn S, Hou, Kangcheng, Zhou, Aaron, Pasaniuc, Bogdan, Sankararaman, Sriram
Published in Nature communications (11.08.2020)
Published in Nature communications (11.08.2020)
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Journal Article
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization
Pathak, Gita A, Singh, Kritika, Miller-Fleming, Tyne W, Wendt, Frank R, Ehsan, Nava, Hou, Kangcheng, Johnson, Ruth, Lu, Zeyun, Gopalan, Shyamalika, Yengo, Loic, Mohammadi, Pejman, Pasaniuc, Bogdan, Polimanti, Renato, Davis, Lea K, Mancuso, Nicholas
Published in Nature communications (27.07.2021)
Published in Nature communications (27.07.2021)
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Journal Article
Optimized design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis
Mandric, Igor, Schwarz, Tommer, Majumdar, Arunabha, Hou, Kangcheng, Briscoe, Leah, Perez, Richard, Subramaniam, Meena, Hafemeister, Christoph, Satija, Rahul, Ye, Chun Jimmie, Pasaniuc, Bogdan, Halperin, Eran
Published in Nature communications (30.10.2020)
Published in Nature communications (30.10.2020)
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Journal Article
Additional impact of genetic ancestry over race/ethnicity to prevalence of KRAS mutations and allele-specific subtypes in non-small cell lung cancer
Wang, Xinan, Hou, Kangcheng, Ricciuti, Biagio, Alessi, Joao V., Li, Xihao, Pecci, Federica, Dey, Rounak, Luo, Jia, Awad, Mark M., Gusev, Alexander, Lin, Xihong, Johnson, Bruce E., Christiani, David C.
Published in HGG advances (18.07.2024)
Published in HGG advances (18.07.2024)
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Journal Article
Powerful eQTL mapping through low-coverage RNA sequencing
Schwarz, Tommer, Boltz, Toni, Hou, Kangcheng, Bot, Merel, Duan, Chenda, Loohuis, Loes Olde, Boks, Marco P., Kahn, René S., Ophoff, Roel A., Pasaniuc, Bogdan
Published in HGG advances (14.07.2022)
Published in HGG advances (14.07.2022)
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Journal Article
Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture
Hou, Kangcheng, Burch, Kathryn S, Majumdar, Arunabha, Shi, Huwenbo, Mancuso, Nicholas, Wu, Yue, Sankararaman, Sriram, Pasaniuc, Bogdan
Published in Nature genetics (01.08.2019)
Published in Nature genetics (01.08.2019)
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Journal Article
Polygenic scoring accuracy varies across the genetic ancestry continuum
Ding, Yi, Hou, Kangcheng, Xu, Ziqi, Pimplaskar, Aditya, Petter, Ella, Boulier, Kristin, Privé, Florian, Vilhjálmsson, Bjarni J, Olde Loohuis, Loes M, Pasaniuc, Bogdan
Published in Nature (London) (22.06.2023)
Published in Nature (London) (22.06.2023)
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Journal Article
On powerful GWAS in admixed populations
Hou, Kangcheng, Bhattacharya, Arjun, Mester, Rachel, Burch, Kathryn S, Pasaniuc, Bogdan
Published in Nature genetics (01.12.2021)
Published in Nature genetics (01.12.2021)
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Journal Article
CaricatureShop: Personalized and Photorealistic Caricature Sketching
Han, Xiaoguang, Hou, Kangcheng, Du, Dong, Qiu, Yuda, Cui, Shuguang, Zhou, Kun, Yu, Yizhou
Published in IEEE transactions on visualization and computer graphics (01.07.2020)
Published in IEEE transactions on visualization and computer graphics (01.07.2020)
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Journal Article
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data
Zhang, Martin Jinye, Hou, Kangcheng, Dey, Kushal K, Sakaue, Saori, Jagadeesh, Karthik A, Weinand, Kathryn, Taychameekiatchai, Aris, Rao, Poorvi, Pisco, Angela Oliveira, Zou, James, Wang, Bruce, Gandal, Michael, Raychaudhuri, Soumya, Pasaniuc, Bogdan, Price, Alkes L
Published in Nature genetics (01.10.2022)
Published in Nature genetics (01.10.2022)
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Journal Article
Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes
Burch, Kathryn S., Hou, Kangcheng, Ding, Yi, Wang, Yifei, Gazal, Steven, Shi, Huwenbo, Pasaniuc, Bogdan
Published in American journal of human genetics (07.04.2022)
Published in American journal of human genetics (07.04.2022)
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Journal Article
A multi-dimensional integrative scoring framework for predicting functional variants in the human genome
Li, Xihao, Yung, Godwin, Zhou, Hufeng, Sun, Ryan, Li, Zilin, Hou, Kangcheng, Zhang, Martin Jinye, Liu, Yaowu, Arapoglou, Theodore, Wang, Chen, Ionita-Laza, Iuliana, Lin, Xihong
Published in American journal of human genetics (03.03.2022)
Published in American journal of human genetics (03.03.2022)
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Journal Article
Impact of cross-ancestry genetic architecture on GWASs in admixed populations
Mester, Rachel, Hou, Kangcheng, Ding, Yi, Meeks, Gillian, Burch, Kathryn S., Bhattacharya, Arjun, Henn, Brenna M., Pasaniuc, Bogdan
Published in American journal of human genetics (01.06.2023)
Published in American journal of human genetics (01.06.2023)
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Journal Article
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals
Hou, Kangcheng, Ding, Yi, Xu, Ziqi, Wu, Yue, Bhattacharya, Arjun, Mester, Rachel, Belbin, Gillian M, Buyske, Steve, Conti, David V, Darst, Burcu F, Fornage, Myriam, Gignoux, Chris, Guo, Xiuqing, Haiman, Christopher, Kenny, Eimear E, Kim, Michelle, Kooperberg, Charles, Lange, Leslie, Manichaikul, Ani, North, Kari E, Peters, Ulrike, Rasmussen-Torvik, Laura J, Rich, Stephen S, Rotter, Jerome I, Wheeler, Heather E, Wojcik, Genevieve L, Zhou, Ying, Sankararaman, Sriram, Pasaniuc, Bogdan
Published in Nature genetics (01.04.2023)
Published in Nature genetics (01.04.2023)
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Journal Article
Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders
Boltz, Toni, Schwarz, Tommer, Bot, Merel, Hou, Kangcheng, Caggiano, Christa, Lapinska, Sandra, Duan, Chenda, Boks, Marco P., Kahn, Rene S., Zaitlen, Noah, Pasaniuc, Bogdan, Ophoff, Roel
Published in American journal of human genetics (01.02.2024)
Published in American journal of human genetics (01.02.2024)
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Journal Article
Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms
Patowary, Ashok, Zhang, Pan, Jops, Connor, Vuong, Celine K, Ge, Xinzhou, Hou, Kangcheng, Kim, Minsoo, Gong, Naihua, Margolis, Michael, Vo, Daniel, Wang, Xusheng, Liu, Chunyu, Pasaniuc, Bogdan, Li, Jingyi Jessica, Gandal, Michael J, de la Torre-Ubieta, Luis
Published in Science (American Association for the Advancement of Science) (24.05.2024)
Published in Science (American Association for the Advancement of Science) (24.05.2024)
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