Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer
Long, Wei, Zheng, Bo-Xin, Li, Ying, Huang, Xuan-He, Lin, Dan-Min, Chen, Cui-Cui, Hou, Jin-Qiang, Ou, Tian-Miao, Wong, Wing-Leung, Zhang, Kun, Lu, Yu-Jing
Published in Nucleic acids research (28.02.2022)
Published in Nucleic acids research (28.02.2022)
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A small-sized benzothiazole-indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging
Zheng, Bo-Xin, She, Meng-Ting, Long, Wei, Xu, Yong-Yu, Zhang, Yi-Han, Huang, Xuan-He, Liu, Wenjie, Hou, Jin-Qiang, Wong, Wing-Leung, Lu, Yu-Jing
Published in Chemical communications (Cambridge, England) (07.12.2020)
Published in Chemical communications (Cambridge, England) (07.12.2020)
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Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: Implications for epigenetic regulation
Lin, Jing, Hou, Jin-qiang, Xiang, Han-dan, Yan, Yi-yong, Gu, Yu-chao, Tan, Jia-heng, Li, Ding, Gu, Lian-quan, Ou, Tian-miao, Huang, Zhi-shu
Published in Biochemical and biophysical research communications (19.04.2013)
Published in Biochemical and biophysical research communications (19.04.2013)
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Journal Article
Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach
Hou, Jin-Qiang, Chen, Shuo-Bin, Zan, Li-Peng, Ou, Tian-Miao, Tan, Jia-Heng, Luyt, Leonard G, Huang, Zhi-Shu
Published in Chemical communications (Cambridge, England) (04.01.2015)
Published in Chemical communications (Cambridge, England) (04.01.2015)
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Journal Article
Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands
Ma, Yan, Ou, Tian-Miao, Tan, Jia-Heng, Hou, Jin-Qiang, Huang, Shi-Liang, Gu, Lian-Quan, Huang, Zhi-Shu
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Journal Article
Development of a Universal Colorimetric Indicator for G‑Quadruplex Structures by the Fusion of Thiazole Orange and Isaindigotone Skeleton
Yan, Jin-Wu, Ye, Wen-Jie, Chen, Shuo-Bin, Wu, Wei-Bin, Hou, Jin-Qiang, Ou, Tian-Miao, Tan, Jia-Heng, Li, Ding, Gu, Lian-Quan, Huang, Zhi-Shu
Published in Analytical chemistry (Washington) (07.08.2012)
Published in Analytical chemistry (Washington) (07.08.2012)
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Journal Article
Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G‑Quadruplex Binding Ligands
Wang, Xiaoxiao, Zhou, Chen-Xi, Yan, Jin-Wu, Hou, Jin-Qiang, Chen, Shuo-Bin, Ou, Tian-Miao, Gu, Lian-Quan, Huang, Zhi-Shu, Tan, Jia-Heng
Published in ACS medicinal chemistry letters (10.10.2013)
Published in ACS medicinal chemistry letters (10.10.2013)
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Investigation on fragmentation pathways of rutaecarpine and its two derivatives using electrospray ionization ion-trap time-of-flight tandem mass spectrometry
Wang, Bin, Chu, Wen-Yi, Li, Zeng, Hou, Jin-Qiang, Huang, Shi-Liang, Ou, Tian-Miao, Tan, Jia-Heng, An, Lin-Kun, Li, Ding, Gu, Lian-Quan, Huang, Zhi-Shu
Published in Rapid communications in mass spectrometry (30.09.2010)
Published in Rapid communications in mass spectrometry (30.09.2010)
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Journal Article
Molecular Engineering of Thiazole Orange Dye: Change of Fluorescent Signaling from Universal to Specific upon Binding with Nucleic Acids in Bioassay
Lu, Yu-Jing, Deng, Qiang, Hou, Jin-Qiang, Hu, Dong-Ping, Wang, Zheng-Ya, Zhang, Kun, Luyt, Leonard G, Wong, Wing-Leung, Chow, Cheuk-Fai
Published in ACS chemical biology (15.04.2016)
Published in ACS chemical biology (15.04.2016)
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Journal Article
Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex
Ou, Tian-Miao, Lin, Jing, Lu, Yu-Jing, Hou, Jin-Qiang, Tan, Jia-Heng, Chen, Shu-Han, Li, Zeng, Li, Yan-Ping, Li, Ding, Gu, Lian-Quan, Huang, Zhi-Shu
Published in Journal of medicinal chemistry (25.08.2011)
Published in Journal of medicinal chemistry (25.08.2011)
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Journal Article
Boosting the turn-on fluorescent signaling ability of thiazole orange dyes: The effectiveness of structural modification site and its unusual interaction behavior with nucleic acids
Long, Wei, Lu, Yu-Jing, Zhang, Kun, Huang, Xuan-He, Hou, Jin-Qiang, Cai, Sen-Yuan, Li, Ying, Du, Xian, Luyt, Leonard G., Wong, Wing-Leung, Chow, Cheuk-Fai
Published in Dyes and pigments (01.12.2018)
Published in Dyes and pigments (01.12.2018)
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Journal Article
Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule
Shan, Chan, Lin, Jing, Hou, Jin-Qiang, Liu, Hui-Yun, Chen, Shuo-Bin, Chen, Ai-Chun, Ou, Tian-Miao, Tan, Jia-Heng, Li, Ding, Gu, Lian-Quan, Huang, Zhi-Shu
Published in Nucleic acids research (18.08.2015)
Published in Nucleic acids research (18.08.2015)
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Journal Article
Correction: A study on a telo21 G-quadruplex DNA specific binding ligand: enhancing the molecular recognition ability via the amino group interactions
Li, Dongli, Hou, Jin-Qiang, Long, Wei, Lu, Yu-Jing, Wong, Wing-Leung, Zhang, Kun
Published in RSC advances (22.06.2018)
Published in RSC advances (22.06.2018)
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Journal Article
5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation
Lu, Yu-Jing, Ou, Tian-Miao, Tan, Jia-Heng, Hou, Jin-Qiang, Shao, Wei-Yan, Peng, Dan, Sun, Ning, Wang, Xiao-Dong, Wu, Wei-Bin, Bu, Xian-Zhang, Huang, Zhi-Shu, Ma, Dik-Lung, Wong, Kwok-Yin, Gu, Lian-Quan
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Journal Article
Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation
Yan, Jin-Wu, Li, Yan-Ping, Ye, Wen-Jie, Chen, Shuo-Bin, Hou, Jin-Qiang, Tan, Jia-Heng, Ou, Tian-Miao, Li, Ding, Gu, Lian-Quan, Huang, Zhi-Shu
Published in Bioorganic & medicinal chemistry (15.04.2012)
Published in Bioorganic & medicinal chemistry (15.04.2012)
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Journal Article
Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: A new class of highly selective ligands for G-quadruplex DNA in c- myc oncogene
Ma, Yan, Ou, Tian-Miao, Tan, Jia-Heng, Hou, Jin-Qiang, Huang, Shi-Liang, Gu, Lian-Quan, Huang, Zhi-Shu
Published in European journal of medicinal chemistry (01.05.2011)
Published in European journal of medicinal chemistry (01.05.2011)
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