Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors
Moore, M., Hirte, H. W., Siu, L., Oza, A., Hotte, S. J., Petrenciuc, O., Cihon, F., Lathia, C., Schwartz, B.
Published in Annals of oncology (01.10.2005)
Published in Annals of oncology (01.10.2005)
Get full text
Journal Article
A phase II study of sunitinib in recurrent and/or metastatic adenoid cystic carcinoma (ACC) of the salivary glands: current progress and challenges in evaluating molecularly targeted agents in ACC
Chau, N.G., Hotte, S.J., Chen, E.X., Chin, S.F., Turner, S., Wang, L., Siu, L.L.
Published in Annals of oncology (01.06.2012)
Published in Annals of oncology (01.06.2012)
Get full text
Journal Article
Treatment of mCRPC in the AR-axis-targeted therapy-resistant state
Chi, K., Hotte, S.J., Joshua, A.M., North, S., Wyatt, A.W., Collins, L.L., Saad, F.
Published in Annals of oncology (01.10.2015)
Published in Annals of oncology (01.10.2015)
Get full text
Journal Article
A phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neck
Abdul Razak, A.R., Soulières, D., Laurie, S.A., Hotte, S.J., Singh, S., Winquist, E., Chia, S., Le Tourneau, C., Nguyen-Tan, P.- F., Chen, E.X., Chan, K.K., Wang, T., Giri, N., Mormont, C., Quinn, S., Siu, L.L.
Published in Annals of oncology (01.03.2013)
Published in Annals of oncology (01.03.2013)
Get full text
Journal Article
A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers
Chi, K.N., Yu, E.Y., Jacobs, C., Bazov, J., Kollmannsberger, C., Higano, C.S., Mukherjee, S.D., Gleave, M.E., Stewart, P.S., Hotte, S.J.
Published in Annals of oncology (01.06.2016)
Published in Annals of oncology (01.06.2016)
Get full text
Journal Article
Cabazitaxel versus abiraterone or enzalutamide in poor prognosis metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase II trial
Annala, M., Fu, S., Bacon, J.V.W., Sipola, J., Iqbal, N., Ferrario, C., Ong, M., Wadhwa, D., Hotte, S.J., Lo, G., Tran, B., Wood, L.A., Gingerich, J.R., North, S.A., Pezaro, C.J., Ruether, J.D., Sridhar, S.S., Kallio, H.M.L., Khalaf, D.J., Wong, A., Beja, K., Schönlau, E., Taavitsainen, S., Nykter, M., Vandekerkhove, G., Azad, A.A., Wyatt, A.W., Chi, K.N.
Published in Annals of oncology (01.07.2021)
Published in Annals of oncology (01.07.2021)
Get full text
Journal Article
A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
Sahebjam, S, Bedard, P L, Castonguay, V, Chen, Z, Reedijk, M, Liu, G, Cohen, B, Zhang, W-J, Clarke, B, Zhang, T, Kamel-Reid, S, Chen, H, Ivy, S P, Razak, A R A, Oza, A M, Chen, E X, Hirte, H W, McGarrity, A, Wang, L, Siu, L L, Hotte, S J
Published in British journal of cancer (20.08.2013)
Published in British journal of cancer (20.08.2013)
Get full text
Journal Article
A Phase I study of cyclin-dependent kinase inhibitor, AT7519, in patients with advanced cancer: NCIC Clinical Trials Group IND 177
Chen, E X, Hotte, S, Hirte, H, Siu, L L, Lyons, J, Squires, M, Lovell, S, Turner, S, McIntosh, L, Seymour, L
Published in British journal of cancer (09.12.2014)
Published in British journal of cancer (09.12.2014)
Get full text
Journal Article
Phase II trial of vorinostat in advanced melanoma
Haas, N. B., Quirt, I., Hotte, S., McWhirter, E., Polintan, R., Litwin, S., Adams, P. D., McBryan, T., Wang, L., Martin, L. P., vonMehren, M., Alpaugh, R. K., Zweibel, J., Oza, A.
Published in Investigational new drugs (01.06.2014)
Published in Investigational new drugs (01.06.2014)
Get full text
Journal Article
A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer
Chi, K. N., Ellard, S. L., Hotte, S. J., Czaykowski, P., Moore, M., Ruether, J. D., Schell, A. J., Taylor, S., Hansen, C., Gauthier, I., Walsh, W., Seymour, L.
Published in Annals of oncology (01.04.2008)
Published in Annals of oncology (01.04.2008)
Get full text
Journal Article
Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours
Razak, A R A, Hotte, S J, Siu, L L, Chen, E X, Hirte, H W, Powers, J, Walsh, W, Stayner, L-A, Laughlin, A, Novotny-Diermayr, V, Zhu, J, Eisenhauer, E A
Published in British journal of cancer (01.03.2011)
Published in British journal of cancer (01.03.2011)
Get full text
Journal Article
Bone Health and Bone-targeted Therapies for Prostate Cancer: a Programme in Evidence-based Care — Cancer Care Ontario Clinical Practice Guideline
Alibhai, S.M.H, Zukotynski, K, Walker-Dilks, C, Emmenegger, U, Finelli, A, Morgan, S.C, Hotte, S.J, Winquist, E
Published in Clinical oncology (Royal College of Radiologists (Great Britain)) (01.06.2017)
Published in Clinical oncology (Royal College of Radiologists (Great Britain)) (01.06.2017)
Get full text
Journal Article
Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study
Hotte, S.J., Oza, A., Winquist, E.W., Moore, M., Chen, E.X., Brown, S., Pond, G.R., Dancey, J.E., Hirte, H.W.
Published in Annals of oncology (01.02.2006)
Published in Annals of oncology (01.02.2006)
Get full text
Journal Article
Patients with inflammatory bowel disease exhibit dysregulated responses to microbial DNA
Hotte, Naomi S C, Salim, Saad Y, Tso, Robert H, Albert, Eric J, Bach, Phil, Walker, John, Dieleman, Levinus A, Fedorak, Richard N, Madsen, Karen L
Published in PloS one (23.05.2012)
Published in PloS one (23.05.2012)
Get full text
Journal Article
A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a
Chi, K.N., Beardsley, E., Eigl, B.J., Venner, P., Hotte, S.J., Winquist, E., Ko, Y.-J., Sridhar, S.S., Weber, D., Saad, F.
Published in Annals of oncology (01.01.2012)
Published in Annals of oncology (01.01.2012)
Get full text
Journal Article
A randomized phase II study of cabazitaxel (CAB) vs (ABI) abiraterone or (ENZ) enzalutamide in poor prognosis metastatic castration-resistant prostate cancer (mCRPC)
Chi, K.N., Taavitsainen, S., Iqbal, N., Ferrario, C., Ong, M., Wadhwa, D., Hotte, S.J., Lo, G., Tran, B., Azad, A., Wood, L., Gingerich, J.R., North, S., Pezaro, C.V., Ruether, D., Sridhar, S.S., Annala, M., Bacon, J., Wyatt, A.W.
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
Get full text
Journal Article
A Canadian cancer trials group phase IB study of durvalumab (anti-PD-L1) plus tremelimumab (anti-CTLA-4) given concurrently or sequentially in patients with advanced, incurable solid malignancies
Nehra, J., Bradbury, P. A., Ellis, P. M., Laskin, J., Kollmannsberger, C., Hao, D., Juergens, R. A., Goss, G., Wheatley-Price, P., Hotte, S. J., Gelmon, K., Tinker, A. V., Brown-Walker, P., Gauthier, I., Tu, D., Song, X., Khan, A., Seymour, Lesley, Smoragiewicz, M.
Published in Investigational new drugs (01.10.2020)
Published in Investigational new drugs (01.10.2020)
Get full text
Journal Article
OCTANE (Ontario-wide Cancer Targeted Nucleic Acid Evaluation): a platform for intraprovincial, national, and international clinical data-sharing
Malone, E R, Saleh, R R, Yu, C, Ahmed, L, Pugh, T, Torchia, J, Bartlett, J, Virtanen, C, Hotte, S J, Hilton, J, Welch, S, Robinson, A, McCready, E, Lo, B, Sadikovic, B, Feilotter, H, Hanna, T P, Kamel-Reid, S, Stockley, T L, Siu, L L, Bedard, P L
Published in Current oncology (Toronto) (01.10.2019)
Published in Current oncology (Toronto) (01.10.2019)
Get full text
Journal Article