Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524)
Lo, Michael K, Shrivastava-Ranjan, Punya, Chatterjee, Payel, Flint, Mike, Beadle, James R, Valiaeva, Nadejda, Murphy, Joyce, Schooley, Robert T, Hostetler, Karl Y, Montgomery, Joel M, Spiropoulou, Christina F
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Published in Microbiology spectrum (22.12.2021)
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Cidofovir and (S)-9-[3-Hydroxy-(2-Phosphonomethoxy)Propyl]Adenine Are Highly Effective Inhibitors of Vaccinia Virus DNA Polymerase When Incorporated into the Template Strand
MAGEE, Wendy C, ALDERN, Kathy A, HOSTETLER, Karl Y, EVANS, David H
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Published in Antimicrobial Agents and Chemotherapy (01.02.2008)
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Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir Diphosphate
MAGEE, Wendy C, HOSTELLER, Karl Y, EVANS, David H
Published in Antimicrobial Agents and Chemotherapy (01.08.2005)
Published in Antimicrobial Agents and Chemotherapy (01.08.2005)
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Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia
Khoury, Haytham, He, Ruijuan, Schimmer, Aaron, Beadle, James R, Hostetler, Karl Y, Minden, Mark D
Published in Chemotherapy (Basel) (01.01.2018)
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Ether Lipid-Ester Prodrugs of Acyclic Nucleoside Phosphonates: Activity against Adenovirus Replication In Vitro
Hartline, Caroll B., Gustin, Kortney M., Wan, William B., Ciesla, Stephanie L., Beadle, James R., Hostetler, Karl Y., Kern, Earl R
Published in The Journal of infectious diseases (01.02.2005)
Published in The Journal of infectious diseases (01.02.2005)
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Enhanced Inhibition of Orthopoxvirus Replication In Vitro by Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir
KERN, Earl R, HARTLINE, Caroll, HARDEN, Emma, KEITH, Kathy, RODRIGUEZ, Natalie, BEADLE, James R, HOSTETLER, Karl Y
Published in Antimicrobial Agents and Chemotherapy (01.04.2002)
Published in Antimicrobial Agents and Chemotherapy (01.04.2002)
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Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections
PAINTER, George R, ALMOND, Merrick R, TROST, Lawrence C, LAMPERT, Bernhard M, NEYTS, Johan, DE CLERCQ, Erik, KORBA, Brent E, ALDERN, Kathy A, BEADLE, James R, HOSTETLER, Karl Y
Published in Antimicrobial Agents and Chemotherapy (01.10.2007)
Published in Antimicrobial Agents and Chemotherapy (01.10.2007)
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Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir
Julien, Olivier, Beadle, James R, Magee, Wendy C, Chatterjee, Subhrangsu, Hostetler, Karl Y, Evans, David H, Sykes, Brian D
Published in Journal of the American Chemical Society (23.02.2011)
Published in Journal of the American Chemical Society (23.02.2011)
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Comparative Activities of Lipid Esters of Cidofovir and Cyclic Cidofovir against Replication of Herpesviruses In Vitro
WILLIAMS-AZIZ, Stephanie L, HARTLINE, Caroll B, HARDEN, Emma A, DAILY, Shannon L, PRICHARD, Mark N, KUSHNER, Nicole L, BEADLE, James R, WAN, W. Brad, HOSTETLER, Karl Y, KERN, Earl R
Published in Antimicrobial Agents and Chemotherapy (01.09.2005)
Published in Antimicrobial Agents and Chemotherapy (01.09.2005)
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Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir Exhibit Multiple-Log Enhancement of Antiviral Activity against Cytomegalovirus and Herpesvirus Replication In Vitro
BEADLE, James R, HARTLINE, Caroll, ALDERN, Kathy A, RODRIGUEZ, Natalie, HARDEN, Emma, KERN, Earl R, HOSTETLER, Karl Y
Published in Antimicrobial Agents and Chemotherapy (01.08.2002)
Published in Antimicrobial Agents and Chemotherapy (01.08.2002)
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The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons
WYLES, David L, KAIHARA, Kelly A, KORBA, Brent E, SCHOOLEY, Robert T, BEADLE, James R, HOSTETLER, Karl Y
Published in Antimicrobial Agents and Chemotherapy (01.06.2009)
Published in Antimicrobial Agents and Chemotherapy (01.06.2009)
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A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation
Chen, Mei, Hou, Jiangping, Tan, Guilin, Xie, Peng, Freeman, William R., Beadle, James R., Hostetler, Karl Y., Cheng, Lingyun
Published in Drug delivery (2017)
Published in Drug delivery (2017)
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Oral Hexadecyloxypropyl-Cidofovir Therapy in Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection
BRAVO, Fernando J, BERNSTEIN, David I, BEADLE, James R, HOSTETLER, Karl Y, CARDIN, Rhonda D
Published in Antimicrobial Agents and Chemotherapy (01.01.2011)
Published in Antimicrobial Agents and Chemotherapy (01.01.2011)
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Increased Antiviral Activity of 1-O-Hexadecyloxypropyl-[2-14C]cidofovir in MRC-5 Human Lung Fibroblasts Is Explained by Unique Cellular Uptake and Metabolism
Aldern, Kathy A, Ciesla, Stephanie L, Winegarden, Kristine L, Hostetler, Karl Y
Published in Molecular pharmacology (01.03.2003)
Published in Molecular pharmacology (01.03.2003)
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Inhibition of HIV-1 by Octadecyloxyethyl Esters of (S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl] Nucleosides and Evaluation of Their Mechanism of Action
Magee, Wendy C, Valiaeva, Nadejda, Beadle, James R, Richman, Douglas D, Hostetler, Karl Y, Evans, David H
Published in Antimicrobial Agents and Chemotherapy (01.11.2011)
Published in Antimicrobial Agents and Chemotherapy (01.11.2011)
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