Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery
Pipal, Robert W., Stout, Kenneth T., Musacchio, Patricia Z., Ren, Sumei, Graham, Thomas J. A., Verhoog, Stefan, Gantert, Liza, Lohith, Talakad G., Schmitz, Alexander, Lee, Hsiaoju S., Hesk, David, Hostetler, Eric D., Davies, Ian W., MacMillan, David W. C.
Published in Nature (London) (28.01.2021)
Published in Nature (London) (28.01.2021)
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Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
Walji, Abbas M, Hostetler, Eric D, Selnick, Harold, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Holahan, Marie, O’Malley, Stacey, Purcell, Mona, Riffel, Kerry, Li, Jing, Balsells, Jaume, OBrien, Julie A, Melquist, Stacey, Soriano, Aileen, Zhang, Xiaoping, Ogawa, Aimie, Xu, Serena, Joshi, Elizabeth, Della Rocca, Joseph, Hess, Fred J, Schachter, Joel, Hesk, David, Schenk, David, Struyk, Arie, Babaoglu, Kerim, Lohith, Talakad G, Wang, Yaode, Yang, Kun, Fu, Jianmin, Evelhoch, Jeffrey L, Coleman, Paul J
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232
Hostetler, Eric D, Joshi, Aniket D, Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Purcell, Mona, Gantert, Liza, Riffel, Kerry, Williams, Mangay, O'Malley, Stacey, Miller, Patricia, Selnick, Harold G, Gallicchio, Steven N, Bell, Ian M, Salvatore, Christopher A, Kane, Stefanie A, Li, Chi-Chung, Hargreaves, Richard J, de Groot, Tjibbe, Bormans, Guy, Van Hecken, Anne, Derdelinckx, Inge, de Hoon, Jan, Reynders, Tom, Declercq, Ruben, De Lepeleire, Inge, Kennedy, W P, Blanchard, Rebecca, Marcantonio, Eugene E, Sur, Cyrille, Cook, Jacquelynn J, Van Laere, Koen, Evelhoch, Jeffrey L
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
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Ruminal degradation and intestinal digestibility of protein and amino acids in high-protein feedstuffs commonly used in dairy diets
Paz, H.A., Klopfenstein, T.J., Hostetler, D., Fernando, S.C., Castillo-Lopez, E., Kononoff, P.J.
Published in Journal of dairy science (01.10.2014)
Published in Journal of dairy science (01.10.2014)
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Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles
Koole, Michel, Lohith, Talakad G., Valentine, John L., Bennacef, Idriss, Declercq, Ruben, Reynders, Tom, Riffel, Kerry, Celen, Sofie, Serdons, Kim, Bormans, Guy, Ferry-Martin, Sandrine, Laroque, Philippe, Walji, Abbas, Hostetler, Eric D., Briscoe, Richard J., de Hoon, Jan, Sur, Cyrille, Van Laere, Koen, Struyk, Arie
Published in Molecular imaging and biology (01.02.2020)
Published in Molecular imaging and biology (01.02.2020)
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A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240
Kolinger, Guilherme D., Vállez García, David, Lohith, Talakad G., Hostetler, Eric D., Sur, Cyrille, Struyk, Arie, Boellaard, Ronald, Koole, Michel
Published in EJNMMI research (27.05.2021)
Published in EJNMMI research (27.05.2021)
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Ration formulations containing reduced-fat dried distillers grains with solubles and their effect on lactation performance, rumen fermentation, and intestinal flow of microbial nitrogen in Holstein cows
Castillo-Lopez, E., Ramirez Ramirez, H.A., Klopfenstein, T.J., Hostetler, D., Karges, K., Fernando, S.C., Kononoff, P.J.
Published in Journal of dairy science (01.03.2014)
Published in Journal of dairy science (01.03.2014)
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cGMP production of the radiopharmaceutical [18F]MK‐6240 for PET imaging of human neurofibrillary tangles
Collier, Thomas Lee, Yokell, Daniel L., Livni, Eli, Rice, Peter A., Celen, Sofie, Serdons, Kim, Neelamegam, Ramesh, Bormans, Guy, Harris, Dawn, Walji, Abbas, Hostetler, Eric D., Bennacef, Idriss, Vasdev, Neil
Published in Journal of labelled compounds & radiopharmaceuticals (15.05.2017)
Published in Journal of labelled compounds & radiopharmaceuticals (15.05.2017)
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Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
Raheem, Izzat T., Schreier, John D., Fuerst, Joy, Gantert, Liza, Hostetler, Eric D., Huszar, Sarah, Joshi, Aniket, Kandebo, Monika, Kim, Somang H., Li, Jing, Ma, Bennett, McGaughey, Georgia, Sharma, Sujata, Shipe, William D., Uslaner, Jason, Vandeveer, George H., Yan, Youwei, Renger, John J., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
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Discovery of [11C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors
Cox, Christopher D., Hostetler, Eric D., Flores, Broc A., Evelhoch, Jeffrey L., Fan, Hong, Gantert, Liza, Holahan, Marie, Eng, Waisi, Joshi, Aniket, McGaughey, Georgia, Meng, Xiangjun, Purcell, Mona, Raheem, Izzat T., Riffel, Kerry, Yan, Youwei, Renger, John J., Smith, Sean M., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Synthesis, characterization, and monkey PET studies of [18F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435
Hostetler, Eric D., Eng, Waisi, Joshi, Aniket D., Sanabria-Bohórquez, Sandra, Kawamoto, Hiroshi, Ito, Satoru, O'Malley, Stacey, Krause, Stephen, Ryan, Christine, Patel, Shil, Williams, Mangay, Riffel, Kerry, Suzuki, Gentaroh, Ozaki, Satoshi, Ohta, Hisashi, Cook, Jacquelynn, Burns, H. Donald, Hargreaves, Richard
Published in Synapse (New York, N.Y.) (01.02.2011)
Published in Synapse (New York, N.Y.) (01.02.2011)
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EARLY CLINICAL RESULTS AND PRECLINICAL VALIDATION OF THE O-GLCNACASE (OGA) INHIBITOR MK-8719 AS A NOVEL THERAPEUTIC FOR THE TREATMENT OF TAUOPATHIES
Smith, Sean M, Struyk, Arie, Jonathan, Daniel, Declercq, Ruben, Marcus, Jacob, Toolan, Dawn, Wang, Xiaohai, Schachter, Joel B, Cosden, Mali, Pearson, Michelle, Hess, Fred, Selnick, Harold, Salinas, Cristian, Li, Wenping, Duffy, Joseph, McEachern, Ernest, Vocadlo, David, Renger, John J, Eric, Hostetler D, Forman, Mark, Schoepp, Darryle
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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COMPARING [3 H]MK-6240 AND [3 H]AV-1451(T-807) IN IN VITRO BINDING STUDIES IN BRAIN TISSUES
Zeng, Zhizhen, Miller, Patricia J, Connolly, Brett M, O’Malley, Stacey S, Bennacef, Idriss, Mulhearn, James, David, Schenk J, Hesk, David, Soriano, Aileen, Abbas, Walji, Eric, Hostetler D
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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O2‐13‐04: Early Clinical Results and Preclinical Validation of the O‐Glcnacase (OGA) Inhibitor Mk‐8719 as a Novel Therapeutic for the Treatment of Tauopathies
Smith, Sean M., Struyk, Arie, Jonathan, Daniel, Declercq, Ruben, Marcus, Jacob, Toolan, Dawn, Wang, Xiaohai, Schachter, Joel B., Cosden, Mali, Pearson, Michelle, Hess, Fred, Selnick, Harold, Salinas, Cristian, Li, Wenping, Duffy, Joseph, McEachern, Ernest, Vocadlo, David, Renger, John J., Eric, Hostetler D., Forman, Mark, Schoepp, Darryle
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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DISCOVERY AND FIRST-IN-HUMAN EVALUATION OF THE TAU-IMAGING PET RADIOTRACER [18 F]MK-6240
Bennacef, Idriss, Zeng, Zhizhen, Lohith, Talakad, Miller, Patricia J, Salinas, Cristian A, Connolly, Brett M, Gantert, Liza T, Haley, Hyking D, Marie, Holahan A, O’Malley, Stacey S, Purcell, Mona L, Riffel, Kerry, Coleman, Paul J, Li, Jing, Balsells-Padros, Jaume, Soriano, Aileen, Ogawa, Aimie M, Xu, Serena, Xiaoping, Zhang, Della Rocca, Joseph, Schachter, Joel B, Hesk, David, David, Schenk J, Telan-Choing, Florestina, Struyk, Arie, Sur, Cyrille, Celen, Sofie, Serdons, Kim, Bormans, Guy, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Hoon, Jan, Koole, Michel, Van Laere, Koen, Declercq, Ruben, Tom, Reynders, Abbas, Walji, Eric, Hostetler D, Evelhoch, Jeffrey
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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In Vivo Imaging of the Programmed Death Ligand 1 by 18F PET
González Trotter, Dinko E, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M, Miller, Patricia J, O'Malley, Stacey S, Lin, Shu-An, Getty, Krista L, Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y, Hostetler, Eric D, Evelhoch, Jeffrey L
Published in The Journal of nuclear medicine (1978) (01.11.2017)
Published in The Journal of nuclear medicine (1978) (01.11.2017)
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