Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death
Mimori, Seisuke, Kawada, Koichi, Saito, Ryo, Takahashi, Masato, Mizoi, Kenta, Okuma, Yasunobu, Hosokawa, Masakiyo, Kanzaki, Tetsuto
Published in Biochemical and biophysical research communications (01.10.2019)
Published in Biochemical and biophysical research communications (01.10.2019)
Get full text
Journal Article
Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies
Ishizaki, Yuma, Furihata, Tomomi, Oyama, Yusuke, Ohura, Kayoko, Imai, Teruko, Hosokawa, Masakiyo, Akita, Hidetaka, Chiba, Kan
Published in Biological & pharmaceutical bulletin (01.05.2018)
Published in Biological & pharmaceutical bulletin (01.05.2018)
Get full text
Journal Article
Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1
Takahashi, Masato, Ogawa, Tomohiro, Kashiwagi, Hiroshi, Fukushima, Fumiya, Yoshitsugu, Misaki, Haba, Masami, Hosokawa, Masakiyo
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
Get full text
Journal Article
Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase
Takahashi, Masato, Uehara, Tomoki, Nonaka, Minori, Minagawa, Yuka, Yamazaki, Riona, Haba, Masami, Hosokawa, Masakiyo
Published in European journal of pharmaceutical sciences (30.04.2019)
Published in European journal of pharmaceutical sciences (30.04.2019)
Get full text
Journal Article
Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases
Mizoi, Kenta, Takahashi, Masato, Sakai, Sachiko, Ogihara, Takuo, Haba, Masami, Hosokawa, Masakiyo
Published in Xenobiotica (03.03.2020)
Published in Xenobiotica (03.03.2020)
Get full text
Journal Article
Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1
Takahashi, Masato, Lee, Yeon Joo, Kanayama, Teruhiko, Kondo, Yusuke, Nishio, Kazuki, Mukai, Kota, Haba, Masami, Hosokawa, Masakiyo
Published in European journal of pharmaceutical sciences (01.09.2020)
Published in European journal of pharmaceutical sciences (01.09.2020)
Get full text
Journal Article
Systematic identification and characterization of carboxylesterases in cynomolgus macaques
Uno, Yasuhiro, Uehara, Shotaro, Hosokawa, Masakiyo, Imai, Teruko
Published in Drug metabolism and disposition (01.12.2014)
Published in Drug metabolism and disposition (01.12.2014)
Get full text
Journal Article
Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase
Takahashi, Masato, Hirota, Ibuki, Nakano, Tomoyuki, Kotani, Tomoyuki, Takani, Daisuke, Shiratori, Kana, Choi, Yura, Haba, Masami, Hosokawa, Masakiyo
Published in Drug metabolism and pharmacokinetics (01.06.2021)
Published in Drug metabolism and pharmacokinetics (01.06.2021)
Get full text
Journal Article
Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver
Uno, Yasuhiro, Igawa, Yoshiyuki, Tanaka, Maori, Ohura, Kayoko, Hosokawa, Masakiyo, Imai, Teruko
Published in Xenobiotica (01.02.2019)
Published in Xenobiotica (01.02.2019)
Get full text
Journal Article
Limited Brain Distribution of [3R,4R,5S ]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)
Ose, Atsushi, Ito, Mototsugu, Kusuhara, Hiroyuki, Yamatsugu, Kenzo, Kanai, Motomu, Shibasaki, Masakatsu, Hosokawa, Masakiyo, Schuetz, John D., Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.02.2009)
Published in Drug metabolism and disposition (01.02.2009)
Get full text
Journal Article
P187 - Structure-activity relationship of atorvastatin derivatives for metabolic activation by human carboxylesterase
Mizoi, Kenta, Takahashi, Masato, Sakai, Sachiko, Haba, Masami, Hosokawa, Masakiyo, Ogihara, Takuo
Published in Drug metabolism and pharmacokinetics (2020)
Published in Drug metabolism and pharmacokinetics (2020)
Get full text
Journal Article
Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques
UNO, Yasuhiro, HOSOKAWA, Masakiyo, IMAI, Teruko
Published in Journal of Veterinary Medical Science (01.06.2015)
Published in Journal of Veterinary Medical Science (01.06.2015)
Get full text
Journal Article
Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
Holmes, Roger S, Wright, Matthew W, Laulederkind, Stanley J. F, Cox, Laura A, Hosokawa, Masakiyo, Imai, Teruko, Ishibashi, Shun, Lehner, Richard, Miyazaki, Masao, Perkins, Everett J, Potter, Phillip M, Redinbo, Matthew R, Robert, Jacques, Satoh, Tetsuo, Yamashita, Tetsuro, Yan, Bingfan, Yokoi, Tsuyoshi, Zechner, Rudolf, Maltais, Lois J
Published in Mammalian genome (01.10.2010)
Published in Mammalian genome (01.10.2010)
Get full text
Journal Article