Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
Hosios, Aaron M., Hecht, Vivian C., Danai, Laura V., Johnson, Marc O., Rathmell, Jeffrey C., Steinhauser, Matthew L., Manalis, Scott R., Vander Heiden, Matthew G.
Published in Developmental cell (07.03.2016)
Published in Developmental cell (07.03.2016)
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Journal Article
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
Torrence, Margaret E, MacArthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D
Published in eLife (01.03.2021)
Published in eLife (01.03.2021)
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Journal Article
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin
Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.
Published in Cell metabolism (08.11.2016)
Published in Cell metabolism (08.11.2016)
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Journal Article
Lack of Evidence for PKM2 Protein Kinase Activity
Hosios, Aaron M., Fiske, Brian P., Gui, Dan Y., Vander Heiden, Matthew G.
Published in Molecular cell (03.09.2015)
Published in Molecular cell (03.09.2015)
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Journal Article
Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation
Lunt, Sophia Y., Muralidhar, Vinayak, Hosios, Aaron M., Israelsen, William J., Gui, Dan Y., Newhouse, Lauren, Ogrodzinski, Martin, Hecht, Vivian, Xu, Kali, Acevedo, Paula N. Marín, Hollern, Daniel P., Bellinger, Gary, Dayton, Talya L., Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Vander Heiden, Matthew G.
Published in Molecular cell (08.01.2015)
Published in Molecular cell (08.01.2015)
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Journal Article
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Vander Heiden, Matthew G.
Published in Cell (10.10.2013)
Published in Cell (10.10.2013)
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Journal Article
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Faubert, Brandon, Chan, Sze Ham, Freinkman, Elizaveta, Zacharias, Lauren G., Mathews, Thomas P., Clish, Clary B., DeBerardinis, Ralph J., Lewis, Caroline A., Vander Heiden, Matthew G.
Published in Nature communications (06.12.2019)
Published in Nature communications (06.12.2019)
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Journal Article
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
Schrötter, Sandra, Yuskaitis, Christopher J., MacArthur, Michael R., Mitchell, Sarah J., Hosios, Aaron M., Osipovich, Maria, Torrence, Margaret E., Mitchell, James R., Hoxhaj, Gerta, Sahin, Mustafa, Manning, Brendan D.
Published in Cell reports (Cambridge) (17.05.2022)
Published in Cell reports (Cambridge) (17.05.2022)
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Journal Article
The redox requirements of proliferating mammalian cells
Hosios, Aaron M., Vander Heiden, Matthew G.
Published in The Journal of biological chemistry (18.05.2018)
Published in The Journal of biological chemistry (18.05.2018)
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Journal Article
Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
McNamara, Molly C., Hosios, Aaron M., Torrence, Margaret E., Zhao, Ting, Fraser, Cameron, Wilkinson, Meghan, Kwiatkowski, David J., Henske, Elizabeth P., Wu, Chin-Lee, Sarosiek, Kristopher A., Valvezan, Alexander J., Manning, Brendan D.
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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Journal Article
Aspartate is an endogenous metabolic limitation for tumour growth
Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.
Published in Nature cell biology (01.07.2018)
Published in Nature cell biology (01.07.2018)
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Journal Article
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Mayers, Jared R., Torrence, Margaret E., Danai, Laura V., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Lau, Allison N., Ji, Brian W., Dixit, Purushottam D., Hosios, Aaron M., Muir, Alexander, Chin, Christopher R., Freinkman, Elizaveta, Jacks, Tyler, Wolpin, Brian M., Vitkup, Dennis, Vander Heiden, Matthew G.
Published in Science (American Association for the Advancement of Science) (09.09.2016)
Published in Science (American Association for the Advancement of Science) (09.09.2016)
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Journal Article
Pyrimidine homeostasis is accomplished by directed overflow metabolism
Reaves, Marshall Louis, Young, Brian D., Hosios, Aaron M., Xu, Yi-Fan, Rabinowitz, Joshua D.
Published in Nature (London) (08.08.2013)
Published in Nature (London) (08.08.2013)
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Journal Article
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
Cox, Andrew G, Tsomides, Allison, Yimlamai, Dean, Hwang, Katie L, Miesfeld, Joel, Galli, Giorgio G, Fowl, Brendan H, Fort, Michael, Ma, Kimberly Y, Sullivan, Mark R, Hosios, Aaron M, Snay, Erin, Yuan, Min, Brown, Kristin K, Lien, Evan C, Chhangawala, Sagar, Steinhauser, Matthew L, Asara, John M, Houvras, Yariv, Link, Brian, Vander Heiden, Matthew G, Camargo, Fernando D, Goessling, Wolfram
Published in The EMBO journal (15.11.2018)
Published in The EMBO journal (15.11.2018)
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Journal Article
Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity
Liu, Vivian M., Howell, Andrea J., Hosios, Aaron M., Li, Zhaoqi, Israelsen, William J., Vander Heiden, Matthew G.
Published in FEBS letters (01.02.2020)
Published in FEBS letters (01.02.2020)
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Journal Article
Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate
Dexter, Joseph P., Ward, Patrick S., Dasgupta, Tathagata, Hosios, Aaron M., Gunawardena, Jeremy, Vander Heiden, Matthew G.
Published in The Journal of biological chemistry (28.12.2018)
Published in The Journal of biological chemistry (28.12.2018)
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Journal Article