Utilization of an Intramolecular Hydrogen Bond To Increase the CNS Penetration of an NK1 Receptor Antagonist
Ashwood, Valerie A, Field, Mark J, Horwell, David C, Julien-Larose, Christine, Lewthwaite, Russell A, McCleary, Scott, Pritchard, Martyn C, Raphy, Jenny, Singh, Lakhbir
Published in Journal of medicinal chemistry (05.07.2001)
Published in Journal of medicinal chemistry (05.07.2001)
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Syntheses of novel heterocycles as anticancer agents
Chauhan, Prem M.S., Martins, Cristina J.A., Horwell, David C.
Published in Bioorganic & medicinal chemistry (16.05.2005)
Published in Bioorganic & medicinal chemistry (16.05.2005)
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Journal Article
Highly selective .kappa.-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted cyclohexyl]arylacetamide derivatives
Halfpenny, Paul R, Horwell, David C, Hughes, John, Hunter, John C, Rees, David C
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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Journal Article
A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging
Ley, Steven V., Massi, Alessandro, Rodríguez, Félix, Horwell, David C., Lewthwaite, Russell A., Pritchard, Martyn C., Reid, Alison M.
Published in Angewandte Chemie (International ed.) (16.03.2001)
Published in Angewandte Chemie (International ed.) (16.03.2001)
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Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents
Bryans, Justin S, Davies, Natasha, Gee, Nicolas S, Dissanayake, Visaka U. K, Ratcliffe, Giles S, Horwell, David C, Kneen, Clare O, Morrell, Andrew I, Oles, Ryszard J, O'Toole, John C, Perkins, Gemma M, Singh, Lakhbir, Suman-Chauhan, Nirmala, O'Neill, Jacqueline A
Published in Journal of medicinal chemistry (21.05.1998)
Published in Journal of medicinal chemistry (21.05.1998)
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Journal Article
Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA
MENZLER, S, BIKKER, J. A, SUMAN-CHAUHAN, N, HORWELL, D. C
Published in Bioorganic & medicinal chemistry letters (21.02.2000)
Published in Bioorganic & medicinal chemistry letters (21.02.2000)
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Journal Article
N- vs O-alkylation in 2(1H)-quinolinone derivatives
Guo, Zhao-Xia, Cammidge, Andrew N, McKillop, Alexander, Horwell, David C
Published in Tetrahedron letters (17.09.1999)
Published in Tetrahedron letters (17.09.1999)
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Journal Article
Rationally designed "dipeptoid" analogs of CCK. .alpha.-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties
Horwell, David C, Hughes, John, Hunter, John C, Pritchard, Martyn C, Richardson, Reginald S, Roberts, Edward, Woodruff, Geoffrey N
Published in Journal of medicinal chemistry (01.01.1991)
Published in Journal of medicinal chemistry (01.01.1991)
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Journal Article
Highly selective .kappa.-opioid analgesics. 2. Synthesis and structure activity relationships of novel N-(2-aminocyclohexyl)arylacetamide derivatives
Halfpenny, Paul R, Hill, Raymond G, Horwell, David C, Hughes, John, Hunter, John C, Johnson, Stephen, Rees, David C
Published in Journal of medicinal chemistry (01.07.1989)
Published in Journal of medicinal chemistry (01.07.1989)
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Journal Article
The design of dipeptide helical mimetics: The synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes
Horwell, David C., Howson, William, Ratcliffe, Giles S., Willems, Henriëtte M.G.
Published in Bioorganic & medicinal chemistry (1996)
Published in Bioorganic & medicinal chemistry (1996)
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Journal Article
Use of a Dipeptide Chemical Library in the Development of Non-Peptide Tachykinin NK3 Receptor Selective Antagonists
Boden, Phil, Eden, Jon M, Hodgson, Julie, Horwell, David C, Hughes, John, McKnight, Alexander T, Lewthwaite, Russell A, Pritchard, Martyn C, Raphy, Jenny, Meecham, Ken, Ratcliffe, Giles S, Suman-Chauhan, Nirmala, Woodruff, Geoffrey N
Published in Journal of medicinal chemistry (12.04.1996)
Published in Journal of medicinal chemistry (12.04.1996)
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Journal Article
Rational design of high affinity tachykinin NK1 receptor antagonists
Boyle, S, Guard, S, Higginbottom, M, Horwell, D C, Howson, W, McKnight, A T, Martin, K, Pritchard, M C, O'Toole, J, Raphy, J
Published in Bioorganic & medicinal chemistry (01.05.1994)
Published in Bioorganic & medicinal chemistry (01.05.1994)
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Journal Article
Synthesis of Conformationally Constrained Tryptophan Derivatives
Horwell, David C, Nichols, Paul D, Ratcliffe, Giles S, Roberts, Edward
Published in Journal of organic chemistry (01.08.1994)
Published in Journal of organic chemistry (01.08.1994)
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Journal Article
Quantitative Structure-Activity Relationships (QSARs) of N-Terminus Fragments of NK1 Tachykinin Antagonists: A Comparison of Classical QSARs and Three-Dimensional QSARs from Similarity Matrixes
Horwell, David C, Howson, William, Higginbottom, Michael, Naylor, Dorica, Ratcliffe, Giles S, Williams, Sophie
Published in Journal of medicinal chemistry (01.10.1995)
Published in Journal of medicinal chemistry (01.10.1995)
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Journal Article
Amide bond replacements incorporated into CCK-B selective "dipeptoids"
Fincham, Christopher I, Higginbottom, Michael, Hill, David R, Horwell, David C, O'Toole, John C, Ratcliffe, Giles S, Rees, David C, Roberts, Edward
Published in Journal of medicinal chemistry (01.04.1992)
Published in Journal of medicinal chemistry (01.04.1992)
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